Prevalence of risk factors of cardiovascular events and functional state of the kidneys with comorbidities in patients of different age groups

Russian Journal of Preventive Medicine, Journal Year: 2023, Volume and Issue: 26(1), P. 59 - 59

Published: Jan. 1, 2023

В настоящее время увеличивается численность населения во всем мире, под влиянием динамического изменения социально-экономического статуса регионов растет число факторов риска развития сердечно-сосудистых осложнений (ССО). Распространенность ССО у больных с коморбидными заболеваниями изучена недостаточно.

ЦЕЛЬ ИССЛЕДОВАНИЯ

Осуществить анализ и дисфункции почек при коморбидной патологии среднего, пожилого старческого возраста.

МАТЕРИАЛ И МЕТОДЫ

Проведено одномоментное поперечное (ретроспективное) исследование группы из 228 патологией (КП). Оценивали частоту нарушений липидного, жирового, углеводного, фосфатного обмена, анемии, протеинурии, а также анализировали концентрации показателей маркеров воспаления в сыворотке крови категории снижения почечной функции учетом возраста пола. Сформированы 3 подгруппы возраста: 45—59 лет (n=103); 60—74 года (n=103) 75—90 (n=22). Категорию определяли на основании результатов определения уровня цистатина C расчета клубочковой фильтрации. Результаты исследования проанализированы использованием t-критерия Стьюдента, критерия Манна—Уитни теста ANOVA.

РЕЗУЛЬТАТЫ

У среднего (45—59 лет) частота избыточной массы тела (ИзМТ), ожирения I степени, гиперхолестеринемии (ГХС), гипертриглицеридемии (ГТГ) дислипидемии (ДЛП) составила 35,9, 26,2, 39,8, 30,0 44,6% соответственно. Лабораторные признаки гипергликемии, гиперфосфатемии протеинурии отмечены 22,3, 23,3 36,8% случаев Стадия фильтрационной С2 отмечена 48,5% (54% мужчин 46% женщин), стадии С3 «А», С3»Б», С4 С5 выявлены 13,6, 9,7 4,9% Частота II III степени статистически значимо выше женщин (p<0,05). Концентрация креатинина существенно выше, расчетная скорость фильтрации (рСКФ) ниже мужчин. чаще регистрировались высокие уровни С-реактивного белка (СРБ, 32,6%) по сравнению лицами (23,0%). 61,4%. возрастной ИзМТ, I, 28,1, 5,8% стадия регистрировалась 40,8% (18 24 женщин). Стадии рСКФ «А» «Б» 26,2 16,5% При обследовании лиц получены следующие данные: ГХС (33,0%), ГТГ (35,9%), ДЛП (33,9%), гипергликемия (22,3%) гиперфосфатемия (23,3%). ГХС, среди 7 (13,7%) 27 (51,9%), 16 (31,3%) 21 (40,3%), 12 (23,5%) (51,9%) гипергликемии была выше. Концентрации СРБ, фактора некроза опухоли (TNF-α) интерлейкина-6 (IL-6) были повышенными 8,7 Повышение СРБ отмечалось возраста, то как TNF-α обнаруживались женщин. IL-6 соответственно 50,0, 4,5 40,9% обследованных возрасте 76—90 лет. провоспалительный статус более выраженными, чем Показатели частоты (27,2%), (22,7%), ДЛД (59,0%), (13,6%), анемии (27,2%) (40,9%) значимыми. ИзМТ 22,7 22,7% содержание было больше, величина ниже. наблюдалась 18,1% больных, — 41,0 пациентов Вне зависимости от половой принадлежности выявлена тесная взаимосвязь TNF-α, уровней гемоглобина (r= –0,219; p<0,05), холестерина липопротеинов низкой плотности (r=0,188; p<0,05) (r=0,139; p<0,05). Положительная корреляционная зависимость получена между содержанием триглицеридов (r=0,218; –0,399; –0,205; –0,142; коррелировало со снижением рСКФ.

ЗАКЛЮЧЕНИЕ

Выявленные связи сердечно-сосудистого риска, помогут определить пути персонифицированной вторичной профилактики почечных

Language: Русский

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Eating behavior features and preferred diets in underweight and obese young men

Obesity and metabolism, Journal Year: 2023, Volume and Issue: 20(2), P. 131 - 139

Published: June 6, 2023

BACKGROUND: Actual nutrition and eating behavior features affect the formation of excess or underweight which in turn are risk factors for development chronic non-infectious diseases. AIM: To assess consumption basic nutrients relation to metabolic disorders obese young men military age. MATERIALS AND METHODS: The study enrolled 86 aged 18 23 years that were referred by enlistment office due violations body weight examined hospital. Participants divided into 2 groups depending on value mass index (BMI): group 1 (n=41) — (Uw) men; (n=45) (Ob) men. Anthropometric, hormonal biochemical parameters measured; type disorder (ED) was evaluated using Dutch DEBQ questionnaire, presence severity anxiety depressive assessed Hospital Anxiety Depression Scale; assessment actual diet performed «Somatonic» computer soft. RESULTS: Absolute intake all essential higher Ob relative protein cholesterol Uw men, whereas fats group. EDs statistically significantly more common values anthropometric indicators group, while predominantly demonstrated deficiency fat component did not key values. In carbohydrate metabolism regulation along with increased blood pressure revealed. CONCLUSION: ratio proteins should be taken account dietary regimens composition; need increase proportion reduce intake, contrary amount enhancing energy expenditure specific dynamic food action.

Language: Английский

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Estimation of the frequency and degree of depression in overweight patients

Russian Journal of Preventive Medicine, Journal Year: 2017, Volume and Issue: 20(4), P. 53 - 53

Published: Jan. 1, 2017

Language: Английский

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Losing and «maintaining» body weight is a well-known inequity in the prevention of chronic noncommunicable diseases

Russian Journal of Preventive Medicine, Journal Year: 2022, Volume and Issue: 25(3), P. 85 - 85

Published: Jan. 1, 2022

На сегодняшний день существует много программ по снижению массы тела, включающих в себя как научно обоснованные подходы, так и «новомодные» методы. С ними связаны мифы поводу невозможности «удержания» тела на достигнутом оптимальном уровне после этапа приверженности той или иной стратегии. Результаты крупных проспективных исследований подтвердили возможность поддержания пределах снижения 10% от исходной протяжении 1 года вплоть до 10 лет. Среди предикторов эффективного выделяют индивидуальные когнитивные факторы ряд особенностей диетологических вмешательств. В обзоре приведен анализ результатов клинических исследований, изучающих эффективность показателю достигнутой отдаленном периоде.

Language: Русский

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Obesity trends in populations of the Russian Federation and the United States of America. Thirty-year long dynamics

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2018, Volume and Issue: 17(4), P. 67 - 73

Published: Sept. 24, 2018

Aim. To evaluate the dynamics of obesity and mean body mass index (BMI) in Russia USA various age gender categories during 1975-2014. Material methods. By a repeat analysis one-moment studies Russian US population 1975-1982 2007-2014, values BMI were assessed men women 25-64 y. o. Into analysis, data was included from part Lipid Clinics study multicenter ESSE-RF (Epidemiology cardiovascular diseases risk factors regions Federation). American acquired NHANES (National Health And Nutrition Examination Survey), open access. Total number observations 48974. Results. In 80s XX century all groups levels lower comparing to Russia, there no significant differences. For following 30 years situation improved for <45 — differences with changed modality, currently is than USA. Conclusion. below ago by females ages, males. increase strata women, same, but lesser. Comparison prevalence showed some predominance males, especially young, not statistically significant. had higher regardless age. Currently, young more prevalent USA, >45 old Russia.

Language: Английский

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Health-saving measures in preventing diseases associated with working conditions

Health Care of the Russian Federation, Journal Year: 2021, Volume and Issue: 65(4), P. 372 - 378

Published: Sept. 3, 2021

Introduction. The health of employees harmful industries indicates its disadvantage and dependence on behavioural occupation risk factors, promoting the formation diseases associated with their impact. In this regard, it is essential to improve hygienic medical-preventive measures strengthen restore able-bodied population, based use health-saving principles aimed at developing skills for a healthy lifestyle monitoring predictors functional disorders body workers. purpose study. Implementation evaluation effectiveness preventive using methods optimise production environment extend longevity workers working in conditions. Material methods. Two hundred eighty-two “Starooskolsky plant automotive electrical equipment named after A.M. Mamonov” exposed factors were examined. status was assessed according data periodic medical examinations, documentation, an assessment prevalence priority classes diseases. Behavioural (smoking, physical activity, nature nutrition) indices studied: mass index, biochemical indices. A program proposed tested, including organisational, training unit. Results. studied enterprise showed structure morbidity be formed by cardiovascular pathology, spine joints, respiratory organs, psycho-emotional sphere, endocrinopathy, reaching almost 70%. More than half are overweight against background unbalanced irrational diet, low level lipid metabolism disorders. introduction testing developed saving contributed improving reducing morbidity. Conclusion. recommended set optimising conditions, correcting state employees, prolongation labour longevity.

Language: Английский

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Galectin‑3 in patients with left ventricular hypertrophy and metabolic syndrome

Arterial’naya Gipertenziya (Arterial Hypertension), Journal Year: 2018, Volume and Issue: 24(3), P. 272 - 280

Published: July 30, 2018

Objective . To investigate the serum levels of galectin‑3 in patients with metabolic syndrome (MS) and combination MS left ventricular hypertrophy (LVH), as well to define role this marker fibrosis MS. Design methods The study included 43 (33 had LVH), 33 comparable age without (LVH was diagnosed 10). level determined by enzyme immunoassay kits Platinum ELISA. Results average group significantly higher (1,89 ± 1,71 ng/ml), compared (1,03 0,22 ng/ml, p = 0,006). showed a positive correlation between LVH (r 0,323, 0,004). mean value no evidence 1,2 0,76 — 2,1 2,02 ng/ml. Conclusions In than MS, concomitant it LVH. increased may indicate severity myocardial help for prognosis evaluation.

Language: Английский

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THE ROLE OF POLLUTANTS OF ATMOSPHERIC AIR AND PESTICIDES IN THE DEVELOPMENT OF DIABETES MELLITUS TYPE 2

Hygiene and Sanitation, Journal Year: 2019, Volume and Issue: 98(11), P. 1296 - 1301

Published: Nov. 15, 2019

Introduction. Primary and secondary review of epidemiological studies on the importance atmospheric air pollutants chemical pesticides for development diabetes mellitus is presented. Material methods. The article includes reviews using ISI-Web Science, EMBASE PubMed database systematic meta-analysis, original from RISC until March 2018 to assess cause-effect relationships non-insulin-dependent with pesticides. Results. Chemical pollution considered as a new risk factor insulin resistance CD2, although number publications limited, degree validity findings very wide. evidence base effect incidence type 2 most complete organochlorine (DDT, DDE, HCH) persistent organic pollutants, which are impurities commodity forms individual preparations. It supported by reviews, survey results, content active ingredients in biomaterial, calculations. Data assessing interrelationships glyphosates, chlorophenoxyacetates, pyrethroids other widely used last two decades insufficient statistical generalizations. Intermediate position diabetogenic properties occupies (PM2,5, PM10, NO2). role genetic component, obesity, metabolic disorders conditions technogenic discussed. Conclusion. Targeted needed environmental risks associated caused at this stage organization preventive measures.

Language: Английский

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Sociomedical and behavioral risk factors for body weight disorders in medical students

Russian Journal of Preventive Medicine, Journal Year: 2019, Volume and Issue: 22(6), P. 67 - 67

Published: Jan. 1, 2019

Language: Английский

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The relationship of endothelial dysfunction and metabolic manifestations of obesity

Regional blood circulation and microcirculation, Journal Year: 2020, Volume and Issue: 19(1), P. 53 - 59

Published: April 6, 2020

Introduction . Over the past three decades, prevalence of overweight and obesity in world has grown by almost 30–50% among adults children. A number metabolic hemodynamic disorders, as well pathology many organs systems are often associated with obesity. The aim our study was to compare functional state endothelium various variants complicated (СO). Materials methods included 66 people СO whose average age 47.3 ± 9.9 years, from this group 3 groups were formed depending on complications (dyslipidemia, hypertension impaired glucose tolerance). To assess endothelium, we used method wavelet analysis skin temperature fluctuations during cooling limb; endothelin-1 (ET-1), albuminuria (AC), vascular endothelial growth factor (VEGF) determined markers dysfunction. Results levels VEGF, ET-1 AC did not differ significantly, however, they significantly higher than comparison group. results cold test revealed absence restoration amplitudes equally all CO compared control (post-cold vasodilation indices (IPV) 1 – 0.45 (0.38–0.69, 2 0.59 (0.41–0.83), 0.66 (0.53–0.79), Control 0.91 (0.86–1.06), p<0.05). Correlations between biochemical instrumental dysfunction insulin resistance obtained: correlated (r=0.49; p=0.02), HOMA index (r=0.55; p=0.01); AU value glycemia (r=0.70; p=0.02); IVC vasoconstriction HOMA-IR (r=0.62; p=0.05); IPV-1 decreased increasing VEGF (r=–0.86; p=0.002) p=0.002). IPV-2 inversely level postprandial (r=–0.87; p=0.05), systolic blood pressure (r=–0.55; p=0.04), OT (r=–0.57; p=0.04) (r=–0.58; p=0.04). Conclusion unified basis disorders allows us conclude that factors complex: hyperglycemia, dyslipidemia, arterial hypertension, which makes it difficult identify leading formation

Language: Английский

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