Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 16, 2024
Abstract
Self‐adaptive
hydrogels
that
can
specifically
respond
to
pathological
cues
and
match
the
highly
ordered
tissue
regeneration
process
are
significantly
on‐demand
for
effective
wound
management.
Herein,
multifunctional
marine‐derived
gold
clusterzyme
(AuNCs)‐based
self‐adaptive
with
microenvironment
triggered
release
behavior
elaborately
fabricated
antioxidant,
anti‐inflammatory
immunoregulation.
The
marine
mussel‐derived
catechol
ligands
(L‐3,4‐dihydroxyphenylalanine)
endow
AuNCs
enhanced
superoxide
dismutase‐mimic
activity
due
their
high
affinity
anion
free
radical
(O
2
−
•)
unique
electron
transfer
mechanism,
leading
100%
inhibition
of
O
•.
Upon
uniformly
crosslinking
phenylboronic
acid‐modified
sodium
alginate
(PBA‐Sa),
obtained
AuNCs@PBA‐Sa
exhibit
outstanding
self‐healing
property,
tunable
degradation
good
removability.
Meanwhile,
greatly
enhance
mechanical
property
confer
hydrogel
favorable
adhesion
rapid
hemostasis.
Furthermore,
injectable
not
only
adapt
shape
irregular
wound,
but
also
smartly
microstructure
physiological
diabetic
responsive
upon
break
boronate
ester
bonds.
released
clusterzymes
actively
induce
generation
M2‐macrophage,
demonstrating
an
pro‐regeneration
effect.
Therefore,
present
clusterzyme‐based
hold
great
potential
remolding
dynamic
smart
Modulating
the
inflammatory
microenvironment
can
inhibit
process
of
diseases
(IDs).
A
tri-cross-linked
microenvironment-responsive
hydrogel
with
ideal
mechanical
properties
achieves
triggerable
and
sustained
drug
delivery
regulates
microenvironment.
Here,
this
study
develops
an
(OD-PP@SeNPs)
composed
phenylboronic
acid
grafted
polylysine
(PP),
oxidized
dextran
(OD),
selenium
nanoparticles
(SeNPs).
The
introduction
SeNPs
as
initiators
nano-fillers
into
results
in
extra
cross-linking
polymer
network
through
hydrogen
bonding.
Based
on
Schiff
base
bonds,
Phenylboronate
ester
a
reactive
oxygen
species
(ROS)/pH
dual
responsive
triple-network
is
achieved.
has
injectable,
self-healing,
adhesion,
outstanding
flexibility,
suitable
swelling
capacity,
optimal
biodegradability,
excellent
stimuli-responsive
active
substance
release
performance,
prominent
biocompatibility.
Most
importantly,
ROS
scavenging
pH-regulating
ability
protects
cells
from
oxidative
stress
induces
macrophages
M2
polarization
to
reduce
cytokines
PI3K/AKT/NF-κB
MAPK
pathways,
exerting
anti-inflammatory
effects
reshaping
microenvironment,
thereby
effectively
treating
typical
IDs,
including
S.
aureus
infected
wound
rheumatoid
arthritis
rats.
In
conclusion,
dynamically
injectable
structure
provides
effective
strategy
treat
holding
great
promise
clinical
application.
The
increasingly
aging
society
led
to
a
rise
in
the
prevalence
of
chronic
wounds
(CWs),
posing
significant
burden
public
health
on
global
scale.
One
key
features
CWs
is
presence
maladjusted
immune
microenvironment
characterized
by
persistent
and
excessive
(hyper)inflammation.
A
variety
immunomodulatory
therapies
have
been
proposed
address
this
condition.
Yet,
date,
current
delivery
systems
for
therapy
remain
inadequate
lack
efficiency.
This
highlights
need
new
therapeutic
systems,
such
as
nanosystems,
manage
pathological
inflammatory
imbalance
and,
ultimately,
improve
treatment
outcomes
CWs.
While
plethora
nanosystems
modifying
shown
promising
effects,
literature
intersection
remains
relatively
scarce.
Therefore,
review
aims
provide
comprehensive
overview
pathogenesis
characteristics
CWs,
discuss
important
advancements
our
understanding
CW
healing,
delineate
versatility
applicability
nanosystems-based
management
In
addition,
we
herein
also
shed
light
main
challenges
future
perspectives
rapidly
evolving
research
field.
Advanced Materials,
Год журнала:
2023,
Номер
36(4)
Опубликована: Ноя. 1, 2023
Abstract
The
immune
system
not
only
acts
as
a
defense
against
pathogen
and
cancer
cells,
but
also
plays
an
important
role
in
homeostasis
tissue
regeneration.
Targeting
systems
is
promising
strategy
for
efficient
treatment
regenerative
medicine.
Current
systemic
immunomodulation
therapies
are
usually
associated
with
low
persistence
time,
poor
targeting
to
action
sites,
severe
side
effects.
Due
their
extracellular
matrix‐mimetic
nature,
tunable
properties
diverse
bioactivities,
hydrogels
intriguing
platforms
locally
deliver
immunomodulatory
agents
well
provide
microenvironment
recruit,
activate,
expand
host
cells.
In
this
review,
the
design
considerations,
including
polymer
backbones,
crosslinking
mechanisms,
physicochemical
immunomodulation‐related
components,
of
hydrogel
platforms,
focused
on.
effects
therapeutic
outcomes
therapy
regeneration
different
emphasized,
depots
delivery
agents,
scaffolds
cell
delivery,
depending
on
intrinsic
materials.
Finally,
remained
challenges
current
future
development
discussed.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 116035 - 116035
Опубликована: Дек. 19, 2023
Diabetic
wounds
(DW)
constitute
a
substantial
burden
on
global
healthcare
owing
to
their
widespread
occurrence
as
complication
of
diabetes.
Angiogenesis,
crucial
process,
plays
pivotal
role
in
tissue
recovery
by
supplying
essential
oxygen
and
nutrients
the
injury
site.
Unfortunately,
diabetes
mellitus,
various
factors
disrupt
angiogenesis,
hindering
wound
healing.
While
biomaterials
designed
enhance
angiogenesis
hold
promise
for
treatment
DWs,
there
is
an
urgent
need
more
in-depth
investigations
fully
unlock
potential
clinical
management.
In
this
review,
we
explore
intricate
mechanisms
that
are
DW
recovery.
We
introduce
rational
design
angiogenesis-enhancing
drug
delivery
systems
(DDS)
provide
comprehensive
summary
discussion
diverse
facilitating
Lastly,
address
emerging
challenges
prospects
DDS
healing,
aiming
offer
understanding
critical
issue
solutions.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(23)
Опубликована: Май 13, 2023
The
hostile
oxidative
wound
microenvironment,
defective
angiogenesis,
and
uncontrolled
release
of
therapeutic
factors
are
major
challenges
in
improving
the
diabetic
healing.
Herein,
adipose-derived-stem-cell-derived
exosomes
(Exos)
first
loaded
into
Ag@bovine
serum
albumin
(BSA)
nanoflowers
(Exos-Ag@BSA
NFs)
to
form
a
protective
"pollen-flower"
delivery
structure,
which
further
encapsulated
injectable
collagen
(Col)
hydrogel
NFs/Col)
for
concurrent
remodeling
microenvironment
precise
Exos.
Exos-Ag@BSA
NFs
can
selectively
dissociate
an
triggers
sustained
Ag
ions
(Ag+
)
cascades
controllable
"pollen-like"
Exos
at
target
site,
thus
protecting
from
denaturation.
Such
wound-microenvironment-activated
property
Ag+
effectively
eliminates
bacteria
promotes
apoptosis
impaired
cells,
resulting
improved
regenerative
microenvironment.
Additionally,
NFs/Col
markedly
accelerates
healing
regeneration
vivo
murine
silicone-splinted
excisional
model
by
promoting
blood
perfusion,
tissue
granulation,
deposition,
neovascularization,
re-epithelization.
It
is
anticipated
that
this
work
will
inspire
development
more
delicate
disease-specific
systems
clinical
management.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Фев. 14, 2024
Abstract
Diabetic
wounds,
which
are
a
serious
complication
of
diabetes,
threat
to
most
diabetic
patients
and
there
is
lack
satisfactory
therapeutic
strategies.
Mesenchymal
stem
cell
(MSC)
spheroids
under
intensive
investigation
have
emerged
as
particularly
promising
clinical
therapy
induce
wound
healing;
however,
applications
MSC
lagged
because
the
difficulties
related
proper
preparation,
in
situ
instruction
insufficient
efficacy.
Herein,
novel
Biotin‐
D
FYIGSR
supramolecular
hydrogel
designed
for
three‐dimensional
(3D)
culture
MSCs,
enables
monodispersed
MSCs
form
with
high
efficacy
fairly
suitable
quick
spheroid
harvest.
demonstrated
enhanced
paracrine
function,
exhibited
increased
survival
promoted
three
overlapping
stages
healing
through
integrin
α
2
β
1
subunits.
These
not
only
accelerated
transition
from
inflammatory
phase
proliferation
by
inhibiting
neutrophils
inducing
M2
macrophage
transition,
but
also
neovascularization
at
sites
motivate
skin
regeneration.
Ultimately,
achieved
re‐epithelialization
collagen
deposition
desirable
closure.
induced
facile
solution
safe
efficient
treatment
great
potential
application.
