Marine Drugs,
Год журнала:
2024,
Номер
22(9), С. 417 - 417
Опубликована: Сен. 13, 2024
The
role
of
oxidative
stress
in
health
and
homeostasis
has
generated
interest
the
scientific
community
due
to
its
association
with
cardiovascular
neurodegenerative
diseases,
cancer,
other
diseases.
Therefore,
extensive
research
seeks
identify
new
exogenous
antioxidant
compounds
for
supplementation.
Polysaccharides
are
recognized
their
properties.
However,
polysaccharide
chemical
modifications
often
necessary
enhance
these
dextran
was
conjugated
gallic
acid
(Dex-Gal)
later
combined
fucoidan
A
(FucA)
formulate
blends
aimed
at
achieving
superior
activity
compared
individual
polysaccharides.
factorial
design
employed
combine
FucA
Dex-Gal
different
proportions,
resulting
five
(BLD1,
BLD2,
BLD3,
BLD4,
BLD5).
An
analysis
surface
graphs
from
vitro
tests,
including
total
capacity
(TAC),
reducing
power,
hydroxyl
radical
scavenging,
guided
selection
BLD4
as
optimal
formulation.
Tests
on
3T3
fibroblasts
under
various
conditions
induced
by
hydrogen
peroxide
revealed
that
provided
enhanced
protection
isolated
components.
formulation,
combination
FucA,
showed
promise
an
strategy,
outperforming
components
suggesting
potential
a
supplement
mitigate
adverse
conditions.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
265, С. 131007 - 131007
Опубликована: Март 18, 2024
Derived
from
bountiful
marine
organisms
(predominantly
algae,
fauna,
and
microorganisms),
polysaccharides
oligosaccharides
are
intricate
macromolecules
that
play
a
significant
role
in
the
growth
development
of
life.
Recently,
considerable
attention
has
been
paid
to
as
auspicious
natural
products
due
their
promising
biological
attributes.
Herein,
we
provide
an
overview
recent
advances
miscellaneous
activities
encompasses
anti-cancer,
anti-inflammatory,
antibacterial,
antiviral,
antioxidant,
anti-diabetes
mellitus,
anticoagulant
properties.
Furthermore,
furnish
concise
summary
underlying
mechanisms
governing
behavior
these
macromolecules.
We
hope
this
review
inspires
research
on
medicinal
applications
while
offering
fresh
perspectives
broader
facets.
Heliyon,
Год журнала:
2024,
Номер
10(2), С. e24444 - e24444
Опубликована: Янв. 1, 2024
The
polysaccharides
found
in
Caulerpa
lentillifera
(sea
grape
algae)
are
potentially
an
important
bioactive
resource.
This
study
makes
use
of
RSM
(response
surface
methodology)
to
determine
the
optimal
conditions
for
extraction
valuable
SGP
polysaccharides).
findings
indicated
that
a
water/raw
material
ratio
10:1
mL/g,
temperature
90
°C,
and
time
45
min
would
maximize
yield,
with
experimentation
achieving
yield
21.576
%.
After
undergoing
purification
through
DEAE-52
cellulose
Sephacryl
S-100
column
chromatography,
three
distinct
fractions
were
obtained,
namely
SGP11,
SGP21,
SGP31,
each
possessing
average
molecular
weights
38.24
kDa,
30.13
30.65
respectively.
Following
characterization,
shown
comprise
glucose,
galacturonic
acid,
xylose,
mannose,
while
sulfate
content
was
range
12.2–21.8
Using
Fourier
transform
infrared
spectroscopy
(FT-IR)
it
possible
confirm
absolute
certainty
polysaccharide
attributes
SGP31.
NMR
(nuclear
magnetic
resonance)
made
clear
SGP11
exhibited
α-glycosidic
configurations,
configurations
SGP21
SGP31
instead
β-glycosidic.
vitro
antioxidant
assays
which
conducted
revealed
able
demonstrate
detectable
scavenging
activity
against
1,1-diphenyl-2-picrylhydrazyl
(DPPH)
radicals
2,2′-azino-bis
(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
radical
cations.
All
also
exhibit
capacity
scavenge
NO
dose-dependent
manner.
display
cellular
(CAA)
human
adenocarcinoma
colon
(Caco-2)
cell
line
when
oxidative
damage
induced.
concentration
levels
govern
extent
such
activity.
Moreover,
purified
exert
strong
inhibitory
effects
upon
glycation,
responses
dependent
dosage,
thus
confirming
potential
find
role
as
natural
resource
production
polysaccharide-based
drugs,
or
products
promote
improved
health.
Foods,
Год журнала:
2024,
Номер
13(11), С. 1630 - 1630
Опубликована: Май 23, 2024
Ulva
rigida
green
macroalgae
contain
a
variety
of
polysaccharides.
A
recent
study
investigated
the
optimum
concentration
and
yield
polysaccharide
extraction
from
oven-dried
U.
biomass
using
water-soluble
method
that
adhered
to
safety
standards.
This
utilised
complete
factorial
experiments
examine
effects
varying
factors
on
extraction.
Results
showed
positive
correlation
between
increased
levels
all
higher
yield.
also
found
main
their
interaction
had
significant
impact
extracted
polysaccharides
rigida.
The
highest
content
were
9.5
mg/mL
189
mg/g,
respectively.
Water-soluble
demonstrated
presence
reducing
sugar
(8
mg/g),
phenolics
(0.69
mg/g)
flavonoids
(1.42
exhibited
antioxidant
properties.
revealed
freeze-dried
powders
primarily
composed
monosaccharide
rhamnose.
Preliminary
results
effect
these
probiotics
supplementation
promoted
viable
Lactobacillus
rhamnosus
ATCC
53103
growth
during
cultivation.
discovery
has
potential
revolutionise
human
food
industry
promote
development
functional
ingredients
for
novel
future
products,
with
numerous
applications
in
nutraceutical
pharmaceutical
industries.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 675 - 675
Опубликована: Фев. 3, 2025
Artemisia
ordosica
Krasch.
represents
a
medicinal
species
traditionally
and
extensively
employed
in
traditional
medicine
for
treating
ailments
such
as
rheumatic
arthritis,
sore
throat,
inflammation.
This
study
initially
focuses
on
the
extraction,
purification,
characterization
of
polysaccharides
(AOP).
The
purified
AOP
exhibits
molecular
mass
corresponding
to
9.00
kDa
consists
multiple
monosaccharide
units,
with
glucose
(54.08%)
predominant
component,
followed
by
arabinose
(13.75%),
mannose
(13.43%),
galactose
(12.79%),
xylose
(3.15%),
glucuronic
acid
(0.93%),
galacturonic
(0.67%),
ribose
(0.63%),
fucose
(0.56%),
respectively.
Furthermore,
explore
immune-regulatory
mechanisms
AOP,
peripheral
blood
lymphocytes
(PBLs)
were
cultured
exposed
inhibitors
targeting
receptors
signaling
molecules.
results
indicated
that
TLR4
serves
potential
target
through
which
exerts
its
immunomodulatory
functions.
mitigates
immune
stress
PBLs
triggered
LPS
disrupting
interaction
between
TLR
downregulating
over-activation
nuclear
factor
kappa
B
(NF-κB)
pathway.
In
summary,
shows
promise
feed
additive
protect
animals
from
stress.
