Polymer Science Series A, Год журнала: 2023, Номер 65(6), С. 692 - 701
Опубликована: Дек. 1, 2023
Язык: Английский
ACS Nano, Год журнала: 2024, Номер 18(19), С. 12295 - 12310
Опубликована: Май 2, 2024
Immune checkpoint blockade (ICB) has brought tremendous clinical progress, but its therapeutic outcome can be limited due to insufficient activation of dendritic cells (DCs) and infiltration cytotoxic T lymphocytes (CTLs). Evoking immunogenic cell death (ICD) is one promising strategy promote DC maturation elicit T-cell immunity, whereas low levels ICD induction solid tumors restrict durable antitumor efficacy. Herein, we report a genetically edited membrane-coated cascade nanozyme (gCM@MnAu) for enhanced cancer immunotherapy by inducing activating the stimulator interferon genes (STING) pathway. In tumor microenvironment (TME), gCM@MnAu initiates reaction generates abundant hydroxyl (•OH), resulting in improved chemodynamic therapy (CDT) boosted activation. addition, released Mn
Язык: Английский
Процитировано
29
Molecules, Год журнала: 2023, Номер 28(16), С. 6085 - 6085
Опубликована: Авг. 16, 2023
Indocyanine green (ICG) is an important kind of near infrared (NIR) photosensitive molecules for PTT/PDT therapy as well imaging. When exposed to NIR light, ICG can produce reactive oxygen species (ROS), which kill cancer cells and pathogenic bacteria. Moreover, the absorbed light also be converted into heat by eliminate cells. In addition, it performs exceptionally in optical imaging-guided tumor antimicrobial due its deeper tissue penetration low photobleaching properties near-infrared region compared other dyes. order solve problems water stability multi-function problem molecules, composite nanomaterials based on have been designed widely used, especially fields tumors sterilization. So far, their materials become one most famous sensitive materials. However, there no corresponding review articles focused molecules. this review, molecular structure ICG, material design, light- triggered anti-tumor, antibacterial, clinical applications are reviewed detail, great significance related research.
Язык: Английский
Процитировано
29
Coordination Chemistry Reviews, Год журнала: 2024, Номер 510, С. 215842 - 215842
Опубликована: Апрель 15, 2024
Язык: Английский
Процитировано
14
Materials Horizons, Год журнала: 2024, Номер 11(18), С. 4275 - 4310
Опубликована: Янв. 1, 2024
This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.
Язык: Английский
Процитировано
7
Analytical Chemistry, Год журнала: 2024, Номер 96(19), С. 7697 - 7705
Опубликована: Май 2, 2024
Dual/multimodal imaging strategies are increasingly recognized for their potential to provide comprehensive diagnostic insights in cancer by harnessing complementary data. This study presents an innovative probe that capitalizes on the synergistic benefits of afterglow luminescence and magnetic resonance (MRI), effectively eliminating autofluorescence interference delivering a superior signal-to-noise ratio. Additionally, it facilitates deep tissue penetration enables noninvasive imaging. Despite advantages, only limited number probes have demonstrated capability simultaneously enhance achieve high-resolution MRI Herein, we introduce cutting-edge platform based semiconducting polymer nanoparticles (PFODBT) integrated with NaYF
Язык: Английский
Процитировано
4
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(28)
Опубликована: Июнь 14, 2024
Ferroptosis induction is particularly promising for cancer therapy when the apoptosis pathway compromised. Current strategies in nanomedicine inducing ferroptosis primarily focus on promoting accumulation of reactive oxygen species (ROS). However, presence intracellular antioxidants, such as nuclear factor erythroid 2-related 2 (Nrf2), can limit effectiveness by activating detoxification systems and eliminating ROS. To overcome this challenge, we developed a synergistic ferroptosis-inducing agent modifying manganese (Mn
Язык: Английский
Процитировано
4
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106718 - 106718
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114573 - 114573
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Март 21, 2025
The early diagnosis rate of gastric cancer is low, and most patients are already at an advanced stage by the time they diagnosed, posing significant challenges for treatment exhibiting high recurrence rates, which notably diminish patients’ survival quality life. Therefore, there urgent need to identify methods that can enhance efficacy. Nanomedicine, distinguished its small size, targeting specificity, strong biological compatibility, particularly well-suited address toxic side effects associated with current diagnostic therapeutic approaches cancer. Consequently, application nanomedicine delivery systems in has garnered increasing interest from researchers. This review provides overview recent advancements use nanomaterials as drugs or drug research, encompassing their applications diagnosis, chemotherapy, radiotherapy, surgery, phototherapy, explores promising prospects
Язык: Английский
Процитировано
0