Microenvironment‐Responsive Hydrogels with Detachable Skin Adhesion and Mild‐Temperature Photothermal Property for Chronic Wound Healing
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(51)
Опубликована: Авг. 27, 2023
Abstract
Chronic
wounds
have
emerged
as
a
global
healthcare
burden
that
inability
to
heal
within
an
expected
time
frame
owing
the
complex
pathophysiological
microenvironment,
bacterial
infection,
multidrug
resistance,
and
fragile
skin
tissue.
Tailored
features
of
chronic
wounds,
multifunctional
hydrogel
(GA)
composed
ethylenediamine‐modified
gelatin
(Gela‐amino)
oxidized
sodium
alginate
(Alg─CHO)
is
reported.
The
thermosensitivity
Schiff
base
bonds
endow
GA
hydrogels
with
physiological
temperature‐enhanced
nonirritating
tissue
adhesion
low‐temperature‐triggered
nondestructive
separation,
beneficial
for
management
vulnerable
sensitive
wounds.
In
addition,
exhibit
pH‐responsive
degradation
adapt
acidic
wound
microenvironment.
Under
near‐infrared
(NIR)
irradiation,
DNase
I
enzyme
indocyanine
green‐loaded
(DI@GA)
efficiently
eradicate
drug‐resistant
bacteria
biofilm
subsequently
exert
antibacterial
effect
attributed
bioactity
mild‐temperature
photothermal
therapy
(≈45
°C).
Remarkably,
DI@GA/NIR
accelerate
diabetic
recovery
regeneration
by
dispersing
biofilm,
killing
bacteria,
inhibiting
inflammation,
promoting
collagen
deposition,
improving
angiogenesis.
advanced
without
addition
antibiotics
are
promising
act
skin‐friendly
dressings
rescuing
infectious
stalled
Язык: Английский
Chitosan-based hydrogel dressings for diabetic wound healing via promoting M2 macrophage-polarization
Carbohydrate Polymers,
Год журнала:
2024,
Номер
331, С. 121873 - 121873
Опубликована: Янв. 30, 2024
Язык: Английский
Microenvironment-responsive smart hydrogels with antibacterial activity and immune regulation for accelerating chronic wound healing
Journal of Controlled Release,
Год журнала:
2024,
Номер
368, С. 518 - 532
Опубликована: Март 12, 2024
Язык: Английский
Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing
Biomaterials,
Год журнала:
2025,
Номер
unknown, С. 123134 - 123134
Опубликована: Янв. 1, 2025
Язык: Английский
Hydrogen bonding-mediated phase-transition gelatin-based bioadhesives to regulate immune microenvironment for diabetic wound healing
Zhuoling Tian,
Ruoheng Gu,
Wenyue Xie
и другие.
Bioactive Materials,
Год журнала:
2025,
Номер
46, С. 434 - 447
Опубликована: Янв. 5, 2025
Язык: Английский
Dual physiological responsive structural color hydrogel particles for wound repair
Bioactive Materials,
Год журнала:
2025,
Номер
46, С. 494 - 502
Опубликована: Янв. 7, 2025
Язык: Английский
Smart battery-free and wireless bioelectronic platform based on a nature-skin-derived organohydrogel for chronic wound diagnosis, assessment, and accelerated healing
Nano Energy,
Год журнала:
2023,
Номер
118, С. 108989 - 108989
Опубликована: Окт. 13, 2023
Язык: Английский
Gelatin-based dynamic response antioxidant, anti-inflammatory multifunctional hydrogel for enhanced diabetic wound repair
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
260, С. 129453 - 129453
Опубликована: Янв. 21, 2024
Язык: Английский
A Multifunctional Herb‐Derived Glycopeptide Hydrogel for Chronic Wound Healing
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 30, 2024
Chronic
wounds
constitute
an
increasingly
prevalent
global
healthcare
issue,
characterized
by
recurring
bacterial
infections,
pronounced
oxidative
stress,
compromised
functionality
of
immune
cells,
unrelenting
inflammatory
reactions,
and
deficits
in
angiogenesis.
In
response
to
these
multifaceted
challenges,
the
study
introduced
a
stimulus-responsive
glycopeptide
hydrogel
constructed
oxidized
Bletilla
striata
polysaccharide
(OBSP),
gallic
acid-grafted
ε-Polylysine
(PLY-GA),
paeoniflorin-loaded
micelles
(MIC@Pae),
called
OBPG&MP.
The
emulates
structure
glycoprotein
fibers
extracellular
matrix
(ECM),
exhibiting
exceptional
injectability,
self-healing,
biocompatibility.
It
adapts
responsively
microenvironment
chronic
wounds,
sequentially
releasing
therapeutic
agents
eradicate
infection,
neutralize
reactive
oxygen
species
(ROS),
modulate
macrophage
polarization,
suppress
inflammation,
encourage
vascular
regeneration
ECM
remodeling,
playing
critical
role
across
inflammatory,
proliferative,
remodeling
phases
wound
healing.
Both
vitro
vivo
studies
confirmed
efficacy
OBPG&MP
regulating
enhancing
skin
tissue.
This
research
supports
vast
potential
for
herb-derived
multifunctional
hydrogels
tissue
engineering
regenerative
medicine.
Язык: Английский
Curcumin-loaded chitosan-based hydrogels accelerating S. aureus-infected wound healing
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
259, С. 129111 - 129111
Опубликована: Янв. 2, 2024
Язык: Английский
