Microenvironment‐Responsive Hydrogels with Detachable Skin Adhesion and Mild‐Temperature Photothermal Property for Chronic Wound Healing

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(51)

Published: Aug. 27, 2023

Abstract Chronic wounds have emerged as a global healthcare burden that inability to heal within an expected time frame owing the complex pathophysiological microenvironment, bacterial infection, multidrug resistance, and fragile skin tissue. Tailored features of chronic wounds, multifunctional hydrogel (GA) composed ethylenediamine‐modified gelatin (Gela‐amino) oxidized sodium alginate (Alg─CHO) is reported. The thermosensitivity Schiff base bonds endow GA hydrogels with physiological temperature‐enhanced nonirritating tissue adhesion low‐temperature‐triggered nondestructive separation, beneficial for management vulnerable sensitive wounds. In addition, exhibit pH‐responsive degradation adapt acidic wound microenvironment. Under near‐infrared (NIR) irradiation, DNase I enzyme indocyanine green‐loaded (DI@GA) efficiently eradicate drug‐resistant bacteria biofilm subsequently exert antibacterial effect attributed bioactity mild‐temperature photothermal therapy (≈45 °C). Remarkably, DI@GA/NIR accelerate diabetic recovery regeneration by dispersing biofilm, killing bacteria, inhibiting inflammation, promoting collagen deposition, improving angiogenesis. advanced without addition antibiotics are promising act skin‐friendly dressings rescuing infectious stalled

Language: Английский

---

Chitosan-based hydrogel dressings for diabetic wound healing via promoting M2 macrophage-polarization

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 331, P. 121873 - 121873

Published: Jan. 30, 2024

Language: Английский

---

Microenvironment-responsive smart hydrogels with antibacterial activity and immune regulation for accelerating chronic wound healing

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 518 - 532

Published: March 12, 2024

Language: Английский

---

Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123134 - 123134

Published: Jan. 1, 2025

Language: Английский

---

Hydrogen bonding-mediated phase-transition gelatin-based bioadhesives to regulate immune microenvironment for diabetic wound healing

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 434 - 447

Published: Jan. 5, 2025

Language: Английский

---

Dual physiological responsive structural color hydrogel particles for wound repair

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 494 - 502

Published: Jan. 7, 2025

Language: Английский

---

Photothermal Conjugated Polymer Microneedle with Biofilm Elimination and Angiogenesis for Diabetic Wound Healing

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Diabetic wounds are highly susceptible to bacterial infection, which can lead the formation of biofilms, making diabetic wound healing a major challenge. In this study, composited microneedle that incorporated drug-loaded conjugated polymer nanoparticles and basic fibroblast growth factor was prepared eliminate biofilms promote vascular regeneration. This released minocycline under near-infrared (NIR) light, effectively penetrating biofilms. The photothermal properties polymers, combined with antibacterial action minocycline, contribute eradication elimination drug-resistant bacteria. Moreover, it regulated microenvironment by reducing level oxidative stress, as well production inflammatory factors at site. Meanwhile, boosted cell migration promoted angiogenesis accelerate healing. for biofilm represents promising approach promoting

Language: Английский

---

Smart battery-free and wireless bioelectronic platform based on a nature-skin-derived organohydrogel for chronic wound diagnosis, assessment, and accelerated healing

Nano Energy, Journal Year: 2023, Volume and Issue: 118, P. 108989 - 108989

Published: Oct. 13, 2023

Language: Английский

---

A Multifunctional Herb‐Derived Glycopeptide Hydrogel for Chronic Wound Healing

Small, Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

Chronic wounds constitute an increasingly prevalent global healthcare issue, characterized by recurring bacterial infections, pronounced oxidative stress, compromised functionality of immune cells, unrelenting inflammatory reactions, and deficits in angiogenesis. In response to these multifaceted challenges, the study introduced a stimulus-responsive glycopeptide hydrogel constructed oxidized Bletilla striata polysaccharide (OBSP), gallic acid-grafted ε-Polylysine (PLY-GA), paeoniflorin-loaded micelles (MIC@Pae), called OBPG&MP. The emulates structure glycoprotein fibers extracellular matrix (ECM), exhibiting exceptional injectability, self-healing, biocompatibility. It adapts responsively microenvironment chronic wounds, sequentially releasing therapeutic agents eradicate infection, neutralize reactive oxygen species (ROS), modulate macrophage polarization, suppress inflammation, encourage vascular regeneration ECM remodeling, playing critical role across inflammatory, proliferative, remodeling phases wound healing. Both vitro vivo studies confirmed efficacy OBPG&MP regulating enhancing skin tissue. This research supports vast potential for herb-derived multifunctional hydrogels tissue engineering regenerative medicine.

Language: Английский

---

Gelatin-based dynamic response antioxidant, anti-inflammatory multifunctional hydrogel for enhanced diabetic wound repair

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129453 - 129453

Published: Jan. 21, 2024

Language: Английский

---