Novel Natural Polymer‐Based Hydrogel Patches with Janus Asymmetric‐Adhesion for Emergency Hemostasis and Wound Healing

Advanced Functional Materials, Год журнала: 2024, Номер 34(36)

Опубликована: Апрель 27, 2024

Abstract An asymmetrical wound dressing functions akin to human skin by serving as a protective barrier between and its immediate environment. However, significant challenges persist concerning the robust adhesion properties of hydrogels, particularly when applied in emergency hemostasis healing contexts. Herein, study has successfully synthesized hydrogel patches with Janus asymmetric‐adhesion, denoted HGO‐C, exclusively comprised natural polymers. This achievement is realized through assembly adhesive (HGO) non‐adhesive (CGC), thereby amalgamating their distinct functionalities. The component served physical shield safeguarding against contamination, while hydrogel, contacted surface, firmly adhered it, swiftly arresting bleeding facilitating healing. Cytocompatibility tests, hemolysis antibacterial assays, coagulation assays demonstrated excellent biocompatibility, antibacterial, hemostatic HGO‐C. Finally, vivo experiments, including liver hemorrhage assay assay, unequivocally showed rapid enhanced capabilities Consequently, these distinctive patches, derived from polymers characterized asymmetric properties, may have great potential for real‐life usage clinical patients.

Язык: Английский

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A nano-composite hyaluronic acid-based hydrogel efficiently antibacterial and scavenges ROS for promoting infected diabetic wound healing

Carbohydrate Polymers, Год журнала: 2024, Номер 334, С. 122064 - 122064

Опубликована: Март 15, 2024

Язык: Английский

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Multifunctional polypeptide-based hydrogel bio-adhesives with pro-healing activities and their working principles

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 327, С. 103155 - 103155

Опубликована: Апрель 16, 2024

Язык: Английский

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A carboxymethyl cellulose/chitosan-based hydrogel harvests robust adhesive, on-demand detachment and self-healing performances for deep burn healing

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155552 - 155552

Опубликована: Сен. 12, 2024

Язык: Английский

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Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing

Biomaterials, Год журнала: 2025, Номер unknown, С. 123134 - 123134

Опубликована: Янв. 1, 2025

Язык: Английский

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Double-network hydrogel dressing regulated by cationic polymer-grafted bacterial cellulose for promote rapid healing of infected wounds

Carbohydrate Polymers, Год журнала: 2025, Номер 353, С. 123257 - 123257

Опубликована: Янв. 20, 2025

Язык: Английский

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Thermal‐Cascade Multifunctional Therapeutic Systems for Remotely Controlled Synergistic Treatment of Drug‐Resistant Bacterial Infections

Advanced Functional Materials, Год журнала: 2024, Номер 34(18)

Опубликована: Янв. 23, 2024

Abstract Antimicrobial therapy remains one of the major global challenges, particularly in absence effective treatment strategies for drug‐resistant bacteria. In this study, a comprehensive approach is proposed bacterial wound infections based on development thermal‐cascade multifunctional therapeutic systems (MTSs), spanning from design functional nanoscale materials to macroscopic smart hydrogel. Within MTSs, antibiotic‐loaded hybrid nanoclusters enable targeted delivery and synergistic mild hyperthermia‐antibiotic treatment, strongly suppressing bacteria while demonstrating excellent biocompatibility with normal cells tissues. Furthermore, near‐infrared irradiation can trigger photothermal effects induce gelation thermal‐sensitive hydrogel, forming MTSs serve as highly adaptable, drug‐enriched protective dressings infected wounds. Both vitro vivo results substantiate that enhance bioavailability agents (including internalization tissue penetration), exert completely eradicate bacteria, promoted healing revascularization, demonstrate biocompatibility. This work offers an innovative demonstration address through advancement sophisticated material systems.

Язык: Английский

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Chitosan/rutin multifunctional hydrogel with tunable adhesion, anti-inflammatory and antibacterial properties for skin wound healing

Carbohydrate Polymers, Год журнала: 2024, Номер 343, С. 122492 - 122492

Опубликована: Июль 16, 2024

Язык: Английский

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Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing

Small, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Abstract Diabetic wounds tend to develop into nonhealing associated with the complex inflammatory microenvironment of uncontrollable bacterial infection, reactive oxygen species (ROS) accumulation, and chronic hypoxia. Damaged blood vessels hinder metabolic circulation, aggravating hypoxia, ROS accumulation further exacerbating diabetic wound microenvironment. However, existing treatments a single functionality have difficulty healing complicated wounds. Therefore, developing an integrative strategy improve hostility is urgently needed. Herein, multifunctional genipin (GP)‐crosslinked chitosan (CS)‐based hydrogels decorated biomimetic metal–organic framework (MOF)‐nanozymes natural antibacterial agent chlorogenic acid (CGA), which named MOF/CGA@GP‐CS (MCGC), are prepared. With catalase (CAT)‐like activity, these dual‐metal MOF‐nanozymes promising bioreactors for simultaneously alleviating hypoxia by converting elevated endogenous H 2 O dissolved in In addition, other component polyphenolic CGA acts as mild agent, efficiently inhibiting infection avoiding antibiotic resistance. Impressively, MCGC accelerate infected eliminating oxidative stress, increasing oxygenation, reversing vivo. this work, effective based on hydrogel dressings successfully developed applied management.

Язык: Английский

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A H₂S‐Evolving Alternately‐Catalytic Enzyme Bio‐Heterojunction with Antibacterial and Macrophage‐Reprogramming Activity for All‐Stage Infectious Wound Regeneration

Advanced Materials, Год журнала: 2024, Номер 36(35)

Опубликована: Июнь 29, 2024

The disorder of the macrophage phenotype and hostile by-product lactate evoked by pathogenic infection in hypoxic deep wound inevitably lead to stagnant skin regeneration. In this study, hydrogen sulfide (H

Язык: Английский

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