Novel Natural Polymer‐Based Hydrogel Patches with Janus Asymmetric‐Adhesion for Emergency Hemostasis and Wound Healing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: April 27, 2024

Abstract An asymmetrical wound dressing functions akin to human skin by serving as a protective barrier between and its immediate environment. However, significant challenges persist concerning the robust adhesion properties of hydrogels, particularly when applied in emergency hemostasis healing contexts. Herein, study has successfully synthesized hydrogel patches with Janus asymmetric‐adhesion, denoted HGO‐C, exclusively comprised natural polymers. This achievement is realized through assembly adhesive (HGO) non‐adhesive (CGC), thereby amalgamating their distinct functionalities. The component served physical shield safeguarding against contamination, while hydrogel, contacted surface, firmly adhered it, swiftly arresting bleeding facilitating healing. Cytocompatibility tests, hemolysis antibacterial assays, coagulation assays demonstrated excellent biocompatibility, antibacterial, hemostatic HGO‐C. Finally, vivo experiments, including liver hemorrhage assay assay, unequivocally showed rapid enhanced capabilities Consequently, these distinctive patches, derived from polymers characterized asymmetric properties, may have great potential for real‐life usage clinical patients.

Language: Английский

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A nano-composite hyaluronic acid-based hydrogel efficiently antibacterial and scavenges ROS for promoting infected diabetic wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122064 - 122064

Published: March 15, 2024

Language: Английский

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Multifunctional polypeptide-based hydrogel bio-adhesives with pro-healing activities and their working principles

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 327, P. 103155 - 103155

Published: April 16, 2024

Language: Английский

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A carboxymethyl cellulose/chitosan-based hydrogel harvests robust adhesive, on-demand detachment and self-healing performances for deep burn healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155552 - 155552

Published: Sept. 12, 2024

Language: Английский

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Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123134 - 123134

Published: Jan. 1, 2025

Language: Английский

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Double-network hydrogel dressing regulated by cationic polymer-grafted bacterial cellulose for promote rapid healing of infected wounds

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123257 - 123257

Published: Jan. 20, 2025

Language: Английский

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Thermal‐Cascade Multifunctional Therapeutic Systems for Remotely Controlled Synergistic Treatment of Drug‐Resistant Bacterial Infections

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(18)

Published: Jan. 23, 2024

Abstract Antimicrobial therapy remains one of the major global challenges, particularly in absence effective treatment strategies for drug‐resistant bacteria. In this study, a comprehensive approach is proposed bacterial wound infections based on development thermal‐cascade multifunctional therapeutic systems (MTSs), spanning from design functional nanoscale materials to macroscopic smart hydrogel. Within MTSs, antibiotic‐loaded hybrid nanoclusters enable targeted delivery and synergistic mild hyperthermia‐antibiotic treatment, strongly suppressing bacteria while demonstrating excellent biocompatibility with normal cells tissues. Furthermore, near‐infrared irradiation can trigger photothermal effects induce gelation thermal‐sensitive hydrogel, forming MTSs serve as highly adaptable, drug‐enriched protective dressings infected wounds. Both vitro vivo results substantiate that enhance bioavailability agents (including internalization tissue penetration), exert completely eradicate bacteria, promoted healing revascularization, demonstrate biocompatibility. This work offers an innovative demonstration address through advancement sophisticated material systems.

Language: Английский

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Chitosan/rutin multifunctional hydrogel with tunable adhesion, anti-inflammatory and antibacterial properties for skin wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122492 - 122492

Published: July 16, 2024

Language: Английский

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Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Diabetic wounds tend to develop into nonhealing associated with the complex inflammatory microenvironment of uncontrollable bacterial infection, reactive oxygen species (ROS) accumulation, and chronic hypoxia. Damaged blood vessels hinder metabolic circulation, aggravating hypoxia, ROS accumulation further exacerbating diabetic wound microenvironment. However, existing treatments a single functionality have difficulty healing complicated wounds. Therefore, developing an integrative strategy improve hostility is urgently needed. Herein, multifunctional genipin (GP)‐crosslinked chitosan (CS)‐based hydrogels decorated biomimetic metal–organic framework (MOF)‐nanozymes natural antibacterial agent chlorogenic acid (CGA), which named MOF/CGA@GP‐CS (MCGC), are prepared. With catalase (CAT)‐like activity, these dual‐metal MOF‐nanozymes promising bioreactors for simultaneously alleviating hypoxia by converting elevated endogenous H 2 O dissolved in In addition, other component polyphenolic CGA acts as mild agent, efficiently inhibiting infection avoiding antibiotic resistance. Impressively, MCGC accelerate infected eliminating oxidative stress, increasing oxygenation, reversing vivo. this work, effective based on hydrogel dressings successfully developed applied management.

Language: Английский

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A H₂S‐Evolving Alternately‐Catalytic Enzyme Bio‐Heterojunction with Antibacterial and Macrophage‐Reprogramming Activity for All‐Stage Infectious Wound Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 29, 2024

The disorder of the macrophage phenotype and hostile by-product lactate evoked by pathogenic infection in hypoxic deep wound inevitably lead to stagnant skin regeneration. In this study, hydrogen sulfide (H

Language: Английский

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