Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 30, 2024
Osteosarcoma
is
a
highly
aggressive
bone
cancer
primarily
affecting
children,
adolescents,
and
young
adults.
The
current
gold
standard
for
treatment
of
osteosarcoma
patients
consists
two
to
three
rounds
chemotherapy,
followed
by
extensive
surgical
intervention
from
total
limb
reconstruction
amputation,
additional
chemotherapy.
Although
chemotherapy
has
advanced
the
significantly,
overall
5-year
survival
rate
in
resistant
forms
still
below
20%.
interaction
between
immune
system
long
been
recognized
as
critical
aspect
tumour
growth.
Tumour
cells
within
microenvironment
(TME)
suppress
antitumour
immunity,
immunosuppressive
cytokines
provide
extrinsic
factors
drug
resistance.
Emerging
research
demonstrates
an
immunostimulatory
role
cGAS/STING
pathway
osteosarcoma,
typically
considered
immune-cold
or
immunosuppressed
type.
signalling
appears
drive
innate
response
against
tumours
potentiates
efficacy
other
common
therapies
including
chemo
radiotherapy.
Nanotechnological
delivery
systems
improved
therapy
have
also
under
investigation
recent
years.
This
review
provides
overview
signalling,
its
divergent
roles
context
cancer,
collates
which
activates
adjuvant
immunomodulatory
target
osteosarcoma.
It
will
discuss
nanotechnological
approaches
that
developed
stimulate
cGAS/STING.
Finally,
it
highlight
future
directions
we
believe
be
central
development
this
transformative
field.
Advanced Materials,
Год журнала:
2023,
Номер
36(11)
Опубликована: Дек. 14, 2023
Pyroptosis,
an
emerging
mechanism
of
programmed
cell
death,
holds
great
potential
to
trigger
a
robust
antitumor
immune
response.
Platinum-based
chemotherapeutic
agents
can
induce
pyroptosis
via
caspase-3
activation.
However,
these
also
enhance
cyclooxygenase-2
(COX-2)
expression
in
tumor
tissues,
leading
drug
resistance
and
evasion
pancreatic
cancer
significantly
limiting
the
effectiveness
chemotherapy-induced
pyroptosis.
Here,
amphiphilic
polymer
(denoted
as
PHDT-Pt-In)
containing
both
indomethacin
(In,
COX-2
inhibitor)
platinum(IV)
prodrug
(Pt(IV))
is
developed,
which
responsive
glutathione
(GSH).
This
self-assemble
into
nanoparticles
Pt-In
NP)
that
disintegrate
cells
due
GSH
responsiveness,
releasing
In
inhibit
expression,
hence
overcoming
chemoresistance
amplifying
cisplatin-induced
mouse
model,
NP
growth
elicit
innate
adaptive
responses.
Moreover,
when
combined
with
anti-programmed
death
ligand
(α-PD-L1)
treatment,
demonstrate
ability
completely
suppress
metastatic
tumors,
transforming
"cold
tumors"
"hot
tumors".
Overall,
sustained
release
Pt(IV)
from
amplifies
platinum-drug-induced
long-term
responses,
presenting
generalizable
strategy
for
cancer.
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Июнь 27, 2024
Cuproptosis
is
a
novel
copper-dependent
programmed
cell
death.
The
efficacy
of
cuproptosis
highly
dependent
on
intracellular
copper
accumulation
and
counteracted
by
high
level
glutathione
(GSH)
in
tumor
cells.
Here,
this
work
develops
self-amplified
nanoparticles
(Cel-Cu
NP)
using
celastrol
(Cel),
natural
product
isolated
from
medical
plant.
In
Cel-Cu
NP,
Cel
serves
as
versatile
ionophore,
exhibiting
an
ideal
coordination
capacity
toward
ions
without
compromising
the
induction.
Notably,
can
simultaneously
scavenge
GSH
content
to
amplify
cuproptosis.
Moreover,
further
activates
immunogenic
death
(ICD)
elicit
robust
immune
response.
Combining
with
checkpoint
blockade,
NP
effectively
eradicates
metastatic
tumors
mouse
lung
metastasis
model.
This
study
provides
efficient
nanomedicine
inducing
for
immunotherapy.
Abstract
Cuproptosis,
an
emerging
form
of
programmed
cell
death,
has
received
tremendous
attention
in
cancer
therapy.
However,
the
efficacy
cuproptosis
remains
limited
by
poor
delivery
efficiency
copper
ion
carriers.
Herein,
complex
nanoparticles
(denoted
as
Cu(I)
NP)
are
developed
that
can
efficiently
deliver
into
cells
to
induce
cuproptosis.
NP
demonstrate
stimulus‐responsive
release
complexes,
which
results
mitochondrial
dysfunction
and
promotes
aggregation
lipoylated
dihydrolipoamide
S‐acetyltransferase
(DLAT),
leading
Notably,
not
only
cuproptosis,
but
also
elicit
robust
immune
responses
suppress
tumor
growth.
Overall,
this
study
provides
a
promising
strategy
for
cuproptosis‐based
ACS Nano,
Год журнала:
2024,
Номер
18(17), С. 10979 - 11024
Опубликована: Апрель 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Abstract
Surgical
resection
remains
the
mainstream
treatment
for
malignant
melanoma.
However,
challenges
in
wound
healing
and
residual
tumor
metastasis
pose
significant
hurdles,
resulting
high
recurrence
rates
patients.
Herein,
a
bioactive
injectable
hydrogel
(BG‐Mn
gel
)
formed
by
crosslinking
sodium
alginate
(SA)
with
manganese‐doped
glass
(BG‐Mn)
is
developed
as
versatile
platform
anti‐tumor
immunotherapy
postoperative
The
incorporation
of
Mn
2+
within
(BG)
can
activate
cGAS‐STING
immune
pathway
to
elicit
robust
response
cancer
immunotherapy.
Furthermore,
doping
BG
endows
system
excellent
photothermal
properties,
hence
facilitating
STING
activation
reversing
immune‐suppressive
microenvironment.
exhibits
favorable
angiogenic
capacity
tissue
regenerative
potential,
promotes
cell
migration
vitro.
When
combining
BG‐Mn
anti‐PD‐1
antibody
(α‐PD‐1)
melanoma,
it
shows
enhanced
long‐term
memory
response.
Remarkably,
upregulate
expression
genes
related
blood
vessel
formation
promote
skin
regeneration
when
treating
full‐thickness
wounds.
Overall,
Gel
serves
an
effective
adjuvant
therapy
regulate
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 1, 2024
Abstract
The
in
vivo
fate
of
chemotherapeutic
drugs
plays
a
vital
role
understanding
the
therapeutic
outcome,
side
effects,
and
mechanism.
However,
lack
imaging
abilities
drugs,
tedious
labeling
processes,
premature
leakage
agents
result
loss
fidelity
between
signals.
Herein,
an
amphiphilic
polymer
is
created
by
copolymerization
near‐infrared‐II
(NIR‐II)
fluorophore
tracer
(T)
anticancer
Pt(IV)
prodrug
(D)
cisplatin
hand‐holding
manner
into
one
chain
for
first
time.
obtained
Polyplatin
DT
capable
delivering
fluorophores
concomitantly
at
precise
D/T
ratio,
thereby
resulting
tracking
platinum
even
readout
them
real‐time
via
NIR‐II
imaging.
can
self‐assemble
nanoparticles,
referred
to
as
Nanoplatin
.
Furthermore,
caspase‐3
cleavable
peptide
that
serves
apoptosis
reporter
attached
,
DTR
are
simultaneously
evaluating
efficacy.
Overall,
it
reported
here
design
theranostic
with
drug
tracers,
efficacy
reporters
work
concert
provide
insight
mechanism
action.
