Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
The
diagnosis
and
treatment
of
cancer
face
significant
challenges.
Thus,
precise
controllable
methods
for
effective
tumor
management
are
required.
Sonogenetics
which
combines
ultrasound
technology
with
genetic
engineering
provides
a
promising
solution.
This
approach
utilizes
the
non‐invasive
nature
deep
tissue
penetration
capabilities
to
enable
diagnostics
targeted
therapies
cancer.
review
explores
roles
sonogenetics‐mediated
in
theranostics.
fundamental
properties
mechanisms
underlying
sonogenetics
first
introduced.
Then,
this
work
summarizes
representative
applications
therapy,
including
cell‐based
therapies,
bacteria‐based
eradication
cells.
Additionally,
diagnosis,
focusing
on
engineered
gas
vesicles
(GVs)
situ
generation
GVs
diagnostic
purposes
presented.
Finally,
challenges
clinical
translation
potential
well
discussed.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(40)
Опубликована: Июль 3, 2024
Abstract
Sonodynamic
therapy
(SDT),
as
a
promising
non‐invasive
therapeutic
modality
combining
ultrasound
(US)
and
sonosensitizers
to
produce
cytotoxic
reactive
oxygen
species
(ROS)
for
treating
deep‐seated
tumors,
has
received
increasing
attention
in
recent
years.
Porphyrins
are
multifunctional
organic
materials,
which
can
be
excited
both
by
light
US
ROS
possess
various
fascinating
features,
including
controllable
synthetic
processes,
excellent
biodegradability,
low
cytotoxicity
without
or
US.
Nevertheless,
their
poor
water
solubility,
skin‐photosensitive
toxicity,
insufficient
target
specificity
hinder
clinical
applications
sonosensitizer.
Although
the
issue
may
improved
using
nanoparticle
carriers,
SDT
efficacy
enhanced
with
other
modalities,
such
combination
makes
it
more
confusing
about
true
mechanism
of
SDT.
This
review
will
focus
on
following
points:
1)
Why
porphyrin‐based
considered
most
sonosensitizer
SDT?
2)
Recent
progress
development
sonosensitizers.
3)
What
new
insight
been
gained
years?
4)
The
trend
designing
efficient
existing
challenges.
Finally,
future
perspective
practical
based
discussed.
Abstract
Sonodynamic
therapy
(SDT),
featuring
noninvasive,
deeper
penetration,
low
cost,
and
repeatability,
is
a
promising
approach
for
deep‐seated
tumors.
However,
the
general
or
only
utilization
of
SDT
shows
efficiency
unsatisfactory
treatment
outcomes
due
to
complicated
tumor
microenvironment
(TME)
process.
To
circumvent
issues,
three
feasible
approaches
enhancing
SDT‐based
therapeutic
effects,
including
sonosensitizer
optimization,
strategies
conquering
hypoxia
TME,
combinational
are
summarized,
with
particular
focus
on
combination
other
modalities,
chemodynamic
therapy,
photodynamic
photothermal
chemotherapy,
starvation
gas
immunotherapy.
In
end,
current
challenges
in
tumors
discussed
enhanced
effects
provided.
It
envisioned
that
this
review
will
provide
new
insight
into
strategic
design
high‐efficiency
sonosensitizer‐derived
nanotheranostics,
thereby
augmenting
accelerating
potential
clinical
transformation.
Biomaterials Research,
Год журнала:
2024,
Номер
28
Опубликована: Янв. 1, 2024
It
is
urgent
to
develop
an
alternative
dynamic
therapy-based
method
overcome
the
limited
efficacy
of
traditional
therapy
methods
for
bladder
cancer
and
damage
caused
patients.
Sonodynamic
(SDT)
has
advantages
high
tissue
penetration,
spatiotemporal
selectivity,
being
non-invasive,
representing
emerging
eradicating
deep
solid
tumors.
However,
effectiveness
SDT
often
hindered
by
inefficient
production
reactive
oxygen
species
nondegradability
sonosensitizer.
To
improve
anti-tumor
effect
on
cancer,
herein,
a
BP-based
heterojunction
sonosensitizer
(BFeSe
2
)
was
synthesized
anchoring
FeSe
onto
BP
via
P–Se
bonding
enhance
stability
SDT.
As
result,
BFeSe
showed
great
cytotoxicity
cells
under
ultrasound
(US)
irradiation.
led
notable
inhibition
tumor
growth
in
subcutaneous
models
orthotopic
US
In
addition,
could
also
T2-weighted
magnetic
resonance
imaging
(MRI)
achieve
monitoring
guide
treatment
cancer.
general,
integrates
MRI
functions
precise
treatment,
promising
clinical
potential
theranostics
Advanced Materials,
Год журнала:
2024,
Номер
36(33)
Опубликована: Июнь 18, 2024
Currently,
sonodynamic
therapy
(SDT)
has
limited
therapeutic
outcomes
and
immune
responses,
highlighting
the
urgent
need
for
enhanced
strategies
that
can
stimulate
robust
long-lasting
antitumor
effects.
Microcystis,
a
notorious
microalga,
reveals
possibility
of
mediating
SDT
owing
to
presence
gas
vesicles
(GVs)
phycocyanin
(PC).
Herein,
nontoxic
strain
Microcystis
elabens
(labeled
Me)
is
developed
as
novel
agent
because
it
generates
O
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
The
development
of
efficient
therapeutic
strategies
to
promote
ferroptotic
cell
death
offers
significant
potential
for
hepatocellular
carcinoma
(HCC)
treatment.
Herein,
this
study
presents
an
HCC‐targeted
nanoplatform
that
integrates
bimetallic
FeMoO
4
nanoparticles
with
CO‐releasing
molecules,
and
further
camouflaged
SP94
peptide‐modified
macrophage
membrane
enhanced
ferroptosis‐driven
multi‐modal
therapy
HCC.
Leveraging
the
multi‐enzyme
activities
multivalent
metallic
elements,
not
only
decomposes
H
2
O
generate
oxygen
alleviate
tumor
hypoxia
but
also
depletes
glutathione
inactivate
peroxides
4,
which
amplify
sonodynamic
under
ultrasound
(US)
irradiation.
Meanwhile,
catalyzes
Fenton
reaction
produce
hydroxyl
radicals
chemodynamic
therapy.
Elevated
intracellular
reactive
species
trigger
cascade
release
CO,
leading
lethal
lipid
peroxidation
enhancing
ferroptosis‐mediated
This
demonstrates
robust
anti‐tumor
efficacy
US
irradiation
favorable
biosafety
in
both
subcutaneous
orthotopic
HCC
models,
representing
a
promising
approach
Additionally,
findings
offer
new
insights
into
microenvironment
modulation
optimize
US‐triggered
cancer
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 4, 2025
In
recent
years,
responsive
nanomaterials
have
demonstrated
tremendous
potential
in
biomedical
applications
due
to
their
unique
advantages
precise
drug
delivery
and
controlled
release.
For
complex
diseases
such
as
cancer,
chronic
inflammation,
genetic
disorders,
traditional
treatment
methods
are
often
limited
by
insufficient
targeting
significant
side
effects.
Responsive
nanotechnology,
sensing
specific
internal
or
external
stimuli,
has
significantly
enhanced
the
precision
efficiency
of
treatments.
This
study
systematically
summarizes
technological
trajectory
emerging
research
directions
through
global
patent
literature
data,
employing
main
path
analysis,
derivative
keyword
co-occurrence
analysis.
The
results
reveal
evolution
this
field,
from
optimization
early
single-stimulus-responsive
nano
systems
rise
theranostics
integration,
followed
advancements
multi-stimuli-responsive
synergistic
therapies,
finally,
innovation
biomimetic
material
design.
Each
developmental
phase
increasingly
focused
on
adapting
biological
environments,
achieving
superior
performance,
enhancing
therapeutic
efficacy.
Keyword
analysis
highlights
key
hotspots,
including
design,
multimodal
response
mechanisms.
future,
expected
play
a
pivotal
role
personalized
medicine,
multifunctional
carrier
disease
management,
providing
novel
insights
support
for
medicine.
Chemosensors,
Год журнала:
2025,
Номер
13(2), С. 73 - 73
Опубликована: Фев. 17, 2025
The
present
cancer
diagnostic
techniques
and
contrast
agents
suffer
drawbacks,
adverse
effects,
poor
compatibility
with
patients
due
to
health
variations.
To
improve
the
detection
of
breast
cancer,
this
work
examined
contrasted
prospective
applications
pomegranates,
chitosan
nanoparticles
(Cs
NPs),
pomegranate-loaded
(PCs
NPs)
as
for
based
on
diffuse
reflectance
properties
at
following
laser
frequencies:
red
(670
nm)
near-infrared
(700
808
spectrum.
Herein,
a
platform
is
proposed,
offering
promising
pathway
detection.
PCs
NPs
two
different
pomegranate
contents
(2
5
g/L)
were
synthesized
using
sol–gel
method.
cytotoxicity
developed
nanomaterials
human
normal
(Vero)
(MCF7)
cell
lines
evaluated
in
presence
irradiation
670
nm,
fluorescent
effect
was
observed.
chemical
structures
extract
analyzed
FTIR,
they
then
further
analytically
characterized
dynamic
light
scattering,
zeta
potential,
field-emission
scanning
electron
microscopy.
Results
confirmed
structural
stability
nanomaterials.
Cytotoxicity
measurements
revealed
that
achieved
selective
cytotoxic
toward
tumor
cells.
also
showed
significant
wavelength-dependent
changes
characteristics
between
malignant
NPs,
content
g/L,
enhanced
cells
compared
more
than
three
folds.
These
findings
indicate
potential
distinguish
healthy
reflection
measurements.
