Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126747 - 126747
Опубликована: Дек. 1, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер 34(48)
Опубликована: Июнь 26, 2024
Abstract The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of tumors have highlighted need for multifaceted scaffolds that afford tumor therapy, effective vascularized reconstruction. However, challenging trilemma has emerged in realm balance between achieving appropriate mechanical strength, ensuring biocompatibility, optimizing a degradation rate aligns with bone‐regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing‐based nanospikes first time. This comprises tissue‐specific nanospiked hydroxyapatite decorated magnesium (nMg) adhesive DNA (aDNA). incorporation nMg within polylactic acid (PLA) matrix confers photothermal capabilities helps modulate properties improve biocompatibility platform. Simultaneously, immobilized aDNA contributed enhancement healing. These 3D‐printed tissue‐adhesive platforms exhibit superior offer controlled degradability. Moreover, they enable eradication bacteria osteosarcoma through hyperthermia promote angiogenesis osteogenesis, both vitro vivo. groundbreaking approach poised pave way fabrication design novel implantable biomaterials integrate therapeutic regenerative functions.
Язык: Английский
Процитировано
22
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy broaden their applicability. However, the current nanocarrier-based delivery strategies focus on conventional PSs, neglecting critical issue phototoxicity. In this study, DHUOCl-25, an activatable (aPS) activated by hypochlorous acid, synthesized combining silicon source structure activation unit. DHUOCl-25 functions as silica for synthesizing mesoporous nanostrctures (MSNs) using standardized protocol, enabling synthesis aPS-covalently modified MSNs variety biologic therapeutic applications. On one hand, resulting nano-aPS maintains aPS functionality antibacterial application achieving synergistic action via MB PDT retained cetyltrimethylammonium bromide (CTAB) (antibacterial agent) (DHU-MSNs-2). other exhibits MSN properties drug loading, facilitating integration photodynamic therapy with chemotherapy (DHU-MSNs-6) tumors demonstrating against spinal metastases lung cancer. These results validate developing novel aPSs expanding MSNs.
Язык: Английский
Процитировано
2
ACS Materials Letters, Год журнала: 2024, Номер 6(3), С. 969 - 975
Опубликована: Фев. 15, 2024
The design of a biologically active photosensitizer that effectively combines chemotherapy and photodynamic therapy remains significant challenge. This article introduces DNA targeted photosensitizer, CQA, which integrates the alkylating moiety chlormethine with photosensitizing moiety. Through damage experiments molecular docking, CQA has been demonstrated to act as an effective targeting damaging chemotherapeutic agent via chlormethine. Meanwhile, can substantially amplify under light irradiation. Such enhancement is attributed introduction anthraquinone group, possesses good redox properties acts electron acceptor promote transfer. Consequently, efficiently generates both type-I type-II reactive oxygen species (ROS), exerting excellent (PDT) effect. antitumor efficacy validated results from in vivo tumor growth experiments, H&E staining, IHC analyses. this study emphasizes enhanced ROS generation, underscoring crucial role efficient synergistic chemo- advancing cancer treatment strategies.
Язык: Английский
Процитировано
11
Science China Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
10
Nano Energy, Год журнала: 2024, Номер 125, С. 109530 - 109530
Опубликована: Март 20, 2024
Язык: Английский
Процитировано
7
Nano Today, Год журнала: 2024, Номер 56, С. 102308 - 102308
Опубликована: Май 11, 2024
Язык: Английский
Процитировано
5
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 4, 2025
Photodynamic therapy (PDT) is increasingly regarded as an attractive approach for cancer treatment due to its advantages of low invasiveness, minimal side effects, and high efficiency. Here, two novel Ru(II) complexes 8a,b were designed synthesized by coordinating phenanthroline biquinoline ligands with center, their chemo-photodynamic immunotherapy explored. Both 8a 8b exhibited significant phototoxicity against A549 4T1 tumor cells via type-I/-II PDT. Among them, superior oxygen-independent antitumor effects (IC50s = 1.50–1.76 μM) upon laser irradiation, displayed micromolar-level chemotherapeutic activities, indicating potential chemo/photodynamic dual effects. Furthermore, also initiated ICD cascade, enhancing recruitment maturation antigen-presenting cells, thus triggering a CD8+ T cell immune response. Finally, in vivo experiments demonstrated that inhibition lung breast growth, rates 94.6% 97.3%, respectively. Therefore, the we designed, effective photosensitizers immunoactivators, demonstrate multiple mechanisms, warranting further study.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 2, 2025
Higher and richer nutrient requirements are typical features that distinguish tumor cells from AU: cells, ensuring adequate substrates energy sources for cell proliferation migration. Therefore, deprivation strategies based on targeted technologies can induce impaired viability in which more sensitive than normal cells. In this review, nutrients required by related metabolic pathways introduced, anti-tumor developed to target described. addition the nutritional characteristics of other microenvironment (including macrophages, neutrophils, natural killer T cancer-associated fibroblasts) new also summarized. conclusion, recent advances targeting blockade reviewed, challenges prospects these discussed, theoretical significance optimizing clinical application nutrition strategies.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 23, 2025
CGAS-STING agonists generally lead to hyperimmunity and systemic toxicity, hindering their immunotherapeutic outcomes. Herein, a mitochondrion-targeted nanoagonist (termed HABH) containing boron dipyrromethene (BODIPY)-derived type I photosensitizer (BDP) Au nanoparticle-engineered hollow mesoporous silica (HMSN/AuNPs) has been fabricated for light-controlled mitochondrial stress-inducing agonist-independent cGAS-STING pathway activation. The HABH can actively target tumor tissues release the BDP. Under light illumination, BDP achieves photodynamic therapy (PDT) in mitochondria, generating massive hydroxyl radicals (•OH) inducing stress an oxygen-independent manner, promoting of DNA (mtDNA). Simultaneously, HMSN/AuNPs act as dual nanozymes derive cascade reactions •OH production, elevating intracellular oxidative state, together with BDP-induced stress, finally evoking facilitating interferon. In orthotopic breast models, achieved intratumoral immunoactivation eradicating primary tumors preventing metastasis tumors. Therefore, constructed enabled activation, providing paradigm photoimmunotherapy.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 11, 2024
Язык: Английский
Процитировано
1