Materials & Design,
Год журнала:
2023,
Номер
226, С. 111604 - 111604
Опубликована: Янв. 6, 2023
The
main
limit
of
hydrogel
used
as
an
independent
wound
dressing
is
its
poor
water
retention,
brittleness,
and
weak
skin
adhesion.
Focusing
on
it,
the
macromolecular
cross-linked
chitosan
polyacrylamide
double
network
(C-A)
chosen
a
functional
layer,
another
robust
poly(vinyl
alcohol)-polyacrylamide/glycerin
(P-A)
protective
layer
designed
to
cover
surface,
interfacial
reaction
happens
link
two
layers
tightly
for
achieving
function
synergy.
In
this
double-layer
(DH)
dressing,
surface
P-A
with
strong
locking
ability
could
keep
moist
long
time,
high
strength
toughness
make
maintain
integrity
under
large
deformation
stress
strengthen
protection,
C-A
modest
adhesion
ensures
fit
skin,
synergistic
swelling
guarantee
fast
absorption
exudate.
Moreover,
in
vitro
vivo
tests,
DH
exhibits
excellent
antibacterial
cytocompatibility,
it
significantly
accelerate
tissue
regeneration
closure
than
commercial
hydrocolloid
dressings.
general,
easy
prepare
shows
superior
comprehensive
performance,
revealing
great
potential
use
independently
applied
dressing.
Abstract
Due
to
global
aging
problems,
the
rising
number
of
patients
suffering
from
chronic
or
hard‐to‐heal
acute
wounds
imposes
a
significant
burden
on
healthcare
systems.
Wound
healing
is
complicated
and
dynamic
physiological
process
with
distinct
molecular
cellular
levels
at
each
phase.
Despite
numerous
strategies
advanced
wound
dressings
being
developed,
successful
management
through
smart
dressing
materials
that
can
adapt
changing
microenvironments
address
needs
different
stages
remains
big
challenge.
Over
last
decade,
hydrogel‐based
have
emerged
as
one
most
potent
biomaterials
for
treatment
favorable
biological
characteristics
high
potential
active
intervention
during
wound‐curing
process.
In
current
contribution,
we
present
recent
progress
in
hydrogel
regulate
release
therapeutics
response
external
stimuli
(such
light)
well
endogenous
changes
environments
(e.g.,
temperature,
pH,
glucose,
reactive
oxygen
species)
facilitate
healing.
We
also
introduce
cutting‐edge
technologies
intelligent
“sense‐and‐treat”
combination
built‐in
sensors
sensing
molecules
responsive
hydrogels,
which
enable
real‐time
monitoring
conditions
prompt
on‐demand
therapy.
Biomacromolecules,
Год журнала:
2022,
Номер
23(4), С. 1622 - 1632
Опубликована: Фев. 1, 2022
Antimicrobial
materials
are
an
urgent
need
for
modern
wound
care
in
the
clinic.
Although
traditional
polyurethane
foams
have
proven
to
be
clinically
valuable
treatment,
their
petroleum-originated
preparation
and
bioinert
nature
restricted
efficacy
biomedical
applications.
Here,
we
propose
a
simple
one-step
foaming
method
prepare
lignin-based
(LPUFs)
which
fully
biobased
polyether
polyols
partially
replace
petroleum-based
raw
materials.
The
trace
amount
of
phenolic
hydroxyl
groups
(about
4
mmol)
liquefied
lignin
acts
as
direct
reducing
agent
capping
silver
ions
(less
than
0.3
mmol),
situ
forming
nanoparticles
(Ag
NPs)
within
LPUF
skeleton.
This
newly
proposed
polyurethane/Ag
composite
foam
(named
Ag
NP-LPUF)
shows
improved
mechanical,
thermal,
antibacterial
properties.
It
is
worth
mentioning
that
NP-LPUF
exhibits
more
99%
rate
against
Escherichia
coli
1
h
Staphylococcus
aureus
h.
Evaluations
mice
indicate
antimicrobial
can
effectively
promote
healing
full-thickness
skin
defects.
As
proof
concept,
this
biodegradable
significant
potential
clinical
translation
dressings.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(29), С. 32799 - 32812
Опубликована: Июль 15, 2022
The
surface
structure
and
topography
of
biomaterials
play
a
crucial
role
in
directing
cell
behaviors
fates.
Meanwhile,
asymmetric
dressings
that
mimic
the
natural
skin
have
been
identified
as
an
effective
strategy
for
enhancing
wound
healing.
Inspired
by
superhydrophobic
lotus
leaf,
composite
dressing
was
obtained
constructing
wettability
modification
on
both
sides
sponge
based
electrospinning.
Among
them,
collagen
quaternized
chitosan
fabricated
freeze-drying,
followed
aligned
poly(ε-caprolactone)
(PCL)/gelatin
nanofiber
hydrophilic
inner
layer
hierarchical
micronanostructure
PCL/polystyrene
microsphere
highly
hydrophobic
outer
constructed
each
side
sponge.
proposed
combines
topological
morphology
with
material's
properties
to
effectively
prevent
bacterial
colonization/infection
promote
healing
cellular
behavior.
In
vitro
experimental
results
confirmed
promotes
adhesion,
proliferation,
directed
growth,
migration.
has
good
water
absorption
antibacterial
properties,
while
biomimetic
exhibits
strong
mechanical
resistance
adhesion.
vivo
showed
can
reduce
inflammatory
response,
infection,
accelerate
angiogenesis
epithelial
regeneration,
significantly
severe
burns.
Thus,
bionic
is
expected
be
promising
candidate
burn
Polymers for Advanced Technologies,
Год журнала:
2022,
Номер
34(2), С. 520 - 530
Опубликована: Ноя. 15, 2022
Abstract
Wound
healing
has
always
been
a
great
challenge
throughout
human
history.
Today,
with
substantial
rise
in
chronic
diseases
and
surgical
operations,
there
is
more
demand
for
wound
dressings
to
facilitate
the
process.
Modern
come
different
forms
offer
significant
advantages
over
traditionally
used
passive
bandages
by
inhibiting
microbial
activity
providing
suitable
moist
environment
wound.
Despite
their
widespread
clinical
usage
successful
results
treatment,
even
modern
cannot
promote
as
expected
since
they
are
not
responsive
conditions.
On
other
hand,
smart
can
interact
through
built‐in
sensors
respond
needs.
They
monitor
changes
stages
provide
insightful
information
that
could
affect
treatment
direction.
The
current
manuscript
reviews
evolution
of
from
ancient,
traditional
presents
advanced
class
future
trend
field.
Biomaterials,
Год журнала:
2023,
Номер
295, С. 122029 - 122029
Опубликована: Янв. 28, 2023
Diabetic
wound
healing
has
attracted
widespread
attention
in
biomedical
engineering.
However,
the
harsh
hypoxic
microenvironment
(HME)
comprising
high
glucose
levels,
local
bleeding,
and
bacterial
infection
often
leads
to
formation
of
hyperplastic
scars,
increasing
clinical
demand
for
dressings.
Here,
we
report
a
comprehensive
strategy
using
near-infrared
NIR-assisted
oxygen
delivery
combined
with
bioactive
nature
biopolymers
remodeling
HME.
Black
phosphorus
(BP)
nanosheets
hemoglobin
(Hb)
were
self-assembled
layerwise
onto
electrospun
poly-l-lactide
(PLLA)
nanofibers
charged
quaternized
chitosan
(QCS)
hyaluronic
acid.
BP
converts
NIR
radiation
into
heat
stimulates
Hb
release
situ.
QCS
is
hemostatic
broad-spectrum
antibacterial
material.
Moderate
BP-derived
photothermal
therapy
can
increase
sensitivity
bacteria
QCS.
A
series
composite
dressings
(coded
as
PQBH-n)
different
numbers
layers
fabricated,
vivo
diabetic
potentials
tested.
The
molecular
mechanism
be
partly
attributed
cytokine-cytokine
receptor
interaction.
Notably,
this
based
on
properties
not
only
applicable
fabricating
multifunctional
but
also
great
potential
expanding
engineering
fields.
