International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
266, С. 131277 - 131277
Опубликована: Март 31, 2024
Bacteria-infected
wound
healing
has
attracted
widespread
attention
in
biomedical
engineering.
Wound
dressing
is
a
potential
strategy
for
repairing
infectious
wounds.
However,
the
development
of
with
appropriate
physiochemical,
antibacterial,
and
hemostatic
properties,
remains
challenging.
Hence,
there
motivation
to
develop
new
synthetic
dressings
improve
bacteria-infected
healing.
Here,
we
fabricate
biocompatible
sponge
through
covalent
crosslinking
collagen
(Col),
quaternized
chitosan
(QCS),
graphene
oxide
(GO).
The
resulting
Col-QCS-GO
shows
an
elastic
modulus
1.93-fold
higher
than
Col
due
enhanced
degree
by
GO
incorporation.
Moreover,
fabricated
favorable
porosity
(84.30
±
3.12
%),
water
absorption/retention
(2658.0
113.4
%/1114.0
65.7
hemostasis
capacities
(blood
loss
<50.0
mg).
Furthermore,
antibacterial
property
under
near-infrared
(NIR)
irradiation
significantly
(the
inhibition
rates
are
99.9
%
S.
aureus
E.
coli)
inherent
properties
QCS
photothermal
capabilities
GO.
Finally,
Col-QCS-GO+NIR
exhibits
lowest
percentage
area
(9.05
1.42
%)
at
day
14
compared
control
group
(31.61
1.76
%).
This
study
provides
insights
developing
innovative
sponges
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 355 - 376
Опубликована: Ноя. 26, 2023
Natural
polymers
are
complex
organic
molecules
that
occur
in
the
natural
environment
and
have
not
been
subjected
to
artificial
synthesis.
They
frequently
encountered
various
creatures,
including
mammals,
plants,
microbes.
The
aforementioned
commonly
derived
from
renewable
sources,
possess
a
notable
level
of
compatibility
with
living
organisms,
limited
adverse
effect
on
environment.
As
result,
they
hold
considerable
significance
development
sustainable
environmentally
friendly
goods.
In
recent
times,
there
has
advancement
investigation
potential
uses
field
biomedicine,
specifically
relation
biomaterials
exhibit
antibacterial
antioxidant
characteristics.
This
review
provides
comprehensive
overview
prevalent
utilized
biomedical
domain
throughout
preceding
two
decades.
this
paper,
we
present
examination
components
typical
methods
for
preparation
based
polymers.
Furthermore,
summarize
application
polymer
materials
each
stage
skin
wound
repair.
Finally,
key
findings
insights
into
limitations
current
elucidate
prospects
their
future
field.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
12(16)
Опубликована: Ноя. 15, 2022
Abstract
Since
the
2010s,
demand
for
healthcare
models
has
exceeded
prevailing
resources
available
due
to
rapid
increase
in
aging
population
China.
However,
a
significant
gap
development
of
biomedical
materials
remains,
especially
between
China
and
western
developed
countries.
Collagen
is
major
protein
extracellular
matrix
(ECM)
been
extensively
applied
medical
fields.
Collagen‐based
biomaterials
(CBBs)
are
used
prepare
dressings
dermal
substitutes,
surgical
sutures,
plasma
tissue‐engineered
scaffolds,
drug
delivery
systems;
this
attributed
their
exceptional
biocompatibility,
biodegradability,
hypoimmunogenicity,
coordination
collagen
hosts
tissues.
This
review
provides
thorough
strides
CBB
structures,
crosslinking
forming
technologies,
real‐world
applications.
First,
natural
origin
specific
structures
animal‐derived
non‐animal‐derived
introduced
compared.
Second,
methods
technologies
CBBs
across
board
discussed.
Third,
several
examples
considered
demonstrate
practical
use
highlight
cautionary
notes.
Finally,
underlying
directions
from
an
interdisciplinary
perspective
outlined.
aims
provide
comprehensive
mechanisms
by
which
can
be
uniquely
practically
as
advanced
biomaterial,
hence
providing
options
augmenting
its
Journal of Applied Polymer Science,
Год журнала:
2023,
Номер
141(1)
Опубликована: Окт. 3, 2023
Abstract
In
recent
years,
there
has
been
a
significant
focus
on
bioactive
dressings
suitable
for
treating
chronic
and
acute
wounds.
Electrospinning
nanofibers
are
considered
advanced
dressing
options
due
to
their
high
porosity
permeability
air
water,
effective
barrier
properties
against
external
pathogens,
excellent
resemblance
the
extracellular
matrix
wound
healing
skin
regeneration.
This
article
reviews
advancements
in
application
of
electrospinning
healing.
The
review
begins
with
an
overview
process
methods.
It
then
explores
advantages
disadvantages
different
synthetic
natural
polymers
used
preparation
dressings.
discussed
this
include
collagen,
gelatin,
silk
fibroin,
chitosan,
hyaluronic
acid,
sodium
alginate.
Additionally,
delves
into
commonly
like
polyvinyl
alcohol,
chloride,
polyethylene
lactone,
polylactide,
polyurethane
applications.
Furthermore,
examines
blending
create
high‐performance
also
incorporation
functional
additives,
such
as
antimicrobial
agents,
growth
factors,
extracts,
expedite
tissue
repair.
conclusion,
is
emerging
technology
that
provides
unique
opportunities
designing
more
care
products.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 16, 2024
Abstract
Diabetic
wounds
are
difficult
to
heal,
and
the
key
wound
healing
is
exudate
management
effective
disinfection.
Inspired
by
asymmetric
wettability
of
Janus‐structured
lotus
leaves,
herein
study
has
presented
design
a
biomimetic
Janus
membrane
that
integrates
unidirectional
biofluid
drainage
photothermal‐enhanced
evaporation/sterilization
capabilities
for
accelerating
diabetic
healing.
This
prepared
electrospinning
polyacrylonitrile
(PAN)
nanofiber
containing
polydopamine
(PDA)
on
surface
polypropylene
(PP)
nonwoven
membrane.
Such
PP/PAN
x%PDA
enables
antigravity
“pumping”
water
from
hydrophobic
PP
layer
hydrophilic
PAN
within
22
s
through
contact
points
interface.
The
incorporation
30
wt%
PDA
in
imparts
high
photoabsorption
photothermal
responsiveness,
facilitating
continuous
volatilization
exudate,
achieving
twice
displacement
water,
causing
irreversible
damage
bacteria.
As
result,
it
effectively
alleviates
inflammation
cellular
fibrosis
while
promoting
collagen
deposition
due
its
structure
antibacterial
properties.
Impressively,
such
achieves
an
impressive
closure
rate
96.7%
wounds,
better
than
(59.8%)
conventional
bandages.
Therefore,
this
offers
promising
alternative
chronic
wounds.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 24, 2023
Abstract
The
stimuli-responsive
nanofibers
prepared
by
electrospinning
have
become
an
ideal
material
due
to
their
large
specific
surface
area
and
porosity,
which
can
respond
extremely
quickly
external
environmental
incitement.
As
intelligent
drug
delivery
platform,
efficiently
load
drugs
then
be
stimulated
conditions
(light,
temperature,
magnetic
field,
ultrasound,
pH
or
ROS,
etc.)
achieve
slow,
on-demand
targeted
release,
showing
great
potential
in
areas
such
as
delivery,
tumor
therapy,
wound
dressing,
tissue
engineering.
Therefore,
this
paper
reviews
the
recent
trends
of
electrospun
platforms
field
biomedicine.
