Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
Nanomedicine
has
shown
great
anticancer
potential
by
disrupting
redox
homeostasis
and
increasing
the
levels
of
oxidative
stress,
but
therapeutic
effect
is
limited
factors
including
intrinsic
self‐protection
mechanism
tumors.
Cancer
cell
death
can
be
induced
exploration
different
mechanisms,
such
as
apoptosis,
pyroptosis,
necroptosis,
cuproptosis,
ferroptosis.
The
merging
nanotechnology
with
biomedicine
provided
tremendous
opportunities
to
construct
death‐based
nanomedicine
for
innovative
cancer
therapy.
Nanocarriers
are
not
only
used
targeted
delivery
inducers,
also
components
induce
achieve
efficient
tumor
treatment.
This
review
focuses
on
seven
modalities
mediated
nanomaterials,
ferroptosis,
cuprotosis,
immunogenic
death,
autophagy.
mechanisms
these
described
in
detail,
well
preparation
nanomaterials
that
them
they
exert
their
effects.
Finally,
this
work
describes
future
development
based
current
knowledge
related
nanomaterials.
Abstract
Ferroptosis
is
a
new
form
of
regulated
cell
death
featuring
iron‐dependent
lipid
peroxides
accumulation
to
kill
tumor
cells.
A
growing
body
evidence
has
shown
the
potential
ferroptosis‐based
cancer
therapy
in
eradicating
refractory
malignancies
that
are
resistant
apoptosis‐based
conventional
therapies.
In
recent
years,
studies
have
reported
number
ferroptosis
inducers
can
increase
vulnerability
cells
by
regulating
ferroptosis‐related
signaling
pathways.
Encouraged
rapid
development
ferroptosis‐driven
therapies,
interdisciplinary
fields
combine
ferroptosis,
pharmaceutical
chemistry,
and
nanotechnology
focused.
First,
prerequisites
metabolic
pathways
for
briefly
introduced.
Then,
detail
emerging
designed
boost
ferroptosis‐induced
therapy,
including
metal
complexes,
metal‐based
nanoparticles,
metal‐free
nanoparticles
summarized.
Subsequently,
application
synergistic
strategies
with
apoptosis
other
emphasis
on
use
both
cuproptosis
induce
redox
dysregulation
intracellular
bimetallic
copper/iron
metabolism
disorders
during
treatment
discussed.
Finally,
challenges
associated
clinical
translation
future
directions
potentiating
therapies
highlighted.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Май 2, 2024
As
a
new
form
of
regulated
cell
death,
ferroptosis
has
unraveled
the
unsolicited
theory
intrinsic
apoptosis
resistance
by
cancer
cells.
The
molecular
mechanism
depends
on
induction
oxidative
stress
through
excessive
reactive
oxygen
species
accumulation
and
glutathione
depletion
to
damage
structural
integrity
Due
their
high
loading
tunability,
nanocarriers
can
escort
delivery
ferro-therapeutics
desired
site
enhanced
permeation
or
retention
effect
active
targeting.
This
review
shed
light
necessity
iron
in
growth
fascinating
features
regulating
cycle
metastasis.
Additionally,
we
discussed
ferroptosis-mediated
therapy
using
nanoplatforms
chemical
basis
overcoming
barriers
therapy.
Advanced Materials,
Год журнала:
2023,
Номер
36(9)
Опубликована: Ноя. 4, 2023
The
ferroptosis
pathway
is
recognized
as
an
essential
strategy
for
tumor
treatment.
However,
killing
cells
in
deep
regions
with
agents
still
challenging
because
of
distinct
size
requirements
intratumoral
accumulation
and
penetration.
Herein,
intelligent
nanocapsules
size-switchable
capability
that
responds
to
acid/hyperthermia
stimulation
achieve
are
developed.
These
constructed
using
poly(lactic-co-glycolic)
acid
Pluronic
F127
carrier
materials,
Au-Fe
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 19, 2023
Malignant
melanoma
(MM)
is
the
most
common
and
deadliest
type
of
skin
cancer
associated
with
high
mortality
rates
across
all
races
ethnicities.
Although
present
treatment
options
combined
surgery
provide
short-term
clinical
benefit
in
patients
early
diagnosis
non-metastatic
MM
significantly
increases
probability
survival,
no
efficacious
treatments
are
available
for
MM.
The
etiology
pathogenesis
complex.
Acquired
drug
resistance
a
pool
prognosis
advanced-stage
Thus,
these
require
new
therapeutic
strategies
to
improve
their
response
prognosis.
Multiple
studies
have
revealed
that
ferroptosis,
non-apoptotic
form
regulated
cell
death
(RCD)
characterized
by
iron
dependant
lipid
peroxidation,
can
prevent
development
Recent
indicated
targeting
ferroptosis
promising
strategy
This
review
article
summarizes
core
mechanisms
underlying
cells
its
potential
role
as
target
We
emphasize
emerging
types
small
molecules
inducing
pathways
boosting
antitumor
activity
BRAFi
immunotherapy
uncover
beneficial
effects
treat
also
summarize
application
nanosensitizer-mediated
unique
dynamic
ferroptosis-based
nanodrug
suggests
pharmacological
induction
may
be
