Journal of Molecular Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
Язык: Английский
Journal of Photochemistry and Photobiology B Biology, Год журнала: 2023, Номер 248, С. 112796 - 112796
Опубликована: Окт. 4, 2023
Язык: Английский
Процитировано
46
Small, Год журнала: 2024, Номер 20(25)
Опубликована: Янв. 14, 2024
Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.
Язык: Английский
Процитировано
20
MedComm, Год журнала: 2025, Номер 6(3)
Опубликована: Фев. 23, 2025
Ferroptosis is a distinct form of iron-dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, various signaling pathways, autophagy, have been demonstrated to influence the induction progression ferroptosis. Recent investigations elucidated that ferroptosis plays crucial role in pathogenesis pulmonary disorders, lung injury, chronic obstructive disease, fibrosis, asthma. increasingly recognized as promising novel strategy for cancer treatment. Various immune cells within tumor microenvironment, CD8+ T cells, macrophages, regulatory natural killer dendritic shown induce modulate process through regulation metabolism pathways. Conversely, can reciprocally alter metabolic environment, leading activation or inhibition functions, thereby modulating responses. This paper reviews molecular mechanism describes discusses connection between microenvironment diseases, development prospect their interaction treatment diseases.
Язык: Английский
Процитировано
3
Advanced Functional Materials, Год журнала: 2024, Номер 34(44)
Опубликована: Июль 16, 2024
Abstract Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and inadequacy endogenous H 2 O tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed sonosensitizer Chlorin e6 (Ce6), phenolic GSH consumer naphthazarin, Fe 3+ , followed modification PEG2000, are strategically designed fabricated for ultrasound‐boosted cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under microenvironment response with assistance ultrasound, releasing 2+ Ce6, naphthazarin. Ce6 capable producing singlet oxygen ( 1 ) hydroxyl radicals · OH) ultrasound‐activated sonodynamic therapy Fenton reaction‐mediated chemodynamic (CDT), respectively, which not only induce apoptotic cell death but also lead to effective accumulation lipid peroxidation (LPO), resulting ferroptosis. Meanwhile, released naphthazarin self‐cycling valence alternations /Fe promote significant decrease intracellular contents, further inducing inactivation peroxidase 4 (GPX4) up‐regulation LPO levels, eventually realizing synergistically enhanced This facile feasible design versatile offers a new strategy effectively improving efficiency multimodal cancer therapies.
Язык: Английский
Процитировано
14
Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.
Язык: Английский
Процитировано
12
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Май 2, 2024
As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory intrinsic apoptosis resistance by cancer cells. The molecular mechanism depends on induction oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage structural integrity Due their high loading tunability, nanocarriers can escort delivery ferro-therapeutics desired site enhanced permeation or retention effect active targeting. This review shed light necessity iron in growth fascinating features regulating cycle metastasis. Additionally, we discussed ferroptosis-mediated therapy using nanoplatforms chemical basis overcoming barriers therapy.
Язык: Английский
Процитировано
11
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Июнь 24, 2024
Abstract Pulmonary fibrosis (PF) is a chronic interstitial lung disorder characterized by abnormal myofibroblast activation, accumulation of extracellular matrix (ECM), and thickening fibrotic alveolar walls, resulting in deteriorated function. PF initiated dysregulated wound healing processes triggered factors such as excessive inflammation, oxidative stress, coronavirus disease (COVID-19). Despite advancements understanding the disease’s pathogenesis, effective preventive therapeutic interventions are currently lacking. Ferroptosis, an iron-dependent regulated cell death (RCD) mechanism involving lipid peroxidation glutathione (GSH) depletion, exhibits unique features distinct from other RCD forms (e.g., apoptosis, necrosis, pyroptosis). Imbalance between reactive oxygen species (ROS) production detoxification leads to ferroptosis, causing cellular dysfunction through peroxidation, protein modifications, DNA damage. Emerging evidence points crucial role ferroptosis progression, driving macrophage polarization, fibroblast proliferation, ECM deposition, ultimately contributing tissue scarring. This review provides comprehensive overview latest findings on involvement signaling mechanisms emphasizing potential novel anti-fibrotic approaches targeting for management.
Язык: Английский
Процитировано
11
Bioorganic Chemistry, Год журнала: 2024, Номер 146, С. 107331 - 107331
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
10
Redox Biology, Год журнала: 2025, Номер unknown, С. 103515 - 103515
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Science China Life Sciences, Год журнала: 2023, Номер 67(1), С. 19 - 40
Опубликована: Сен. 15, 2023
Язык: Английский
Процитировано
23