Frontiers in Materials,
Год журнала:
2024,
Номер
10
Опубликована: Янв. 16, 2024
Cell-instructive
biomaterials
are
an
essential
component
in
tissue
engineering
and
regenerative
medicine.
In
the
past
three
decades
since
term
“Tissue
Engineering”
was
coined,
researchers
have
made
significant
progress
towards
regenerating
disease
or
damage
tissues
organs
by
combining
innovations
biomaterials,
signaling
molecules
cell
therapies.
However,
challenges
persist
including
limitations
properties
of
cell-instructive
lack
advanced
manufacturing
technologies
for
precise
spatiotemporal
control
key
players
engineering,
hurdles
clinical
translation
regulatory
process.
this
perspective
article,
we
briefly
review
current
state
field
evolution
our
understanding
role
biomaterial
mechanics
scaffolding
architecture,
development
self-healing
modular
such
as
3D
bioprinting.
addition,
discuss
about
how
innovation
research
multi-omics
spatial
biology,
imaging
modalities
may
pave
way
enhancing
cell-biomaterial
interactions.
Finally,
present
early
career
clinicians
on
potential
impact
that
clinician-scientists
can
generate
development,
validation,
adoption
next-generation
application
to
human
health.
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
321, С. 103030 - 103030
Опубликована: Окт. 20, 2023
The
impairment
of
articular
cartilage
due
to
traumatic
incidents
or
osteoarthritis
has
posed
significant
challenges
for
healthcare
practitioners,
researchers,
and
individuals
suffering
from
these
conditions.
Due
the
absence
an
approved
treatment
strategy
complete
restoration
defects
their
native
state,
tissue
condition
often
deteriorates
over
time,
leading
osteoarthritic
(OA).
However,
recent
advancements
in
field
regenerative
medicine
have
unveiled
promising
prospects
through
utilization
injectable
hydrogels.
This
versatile
class
biomaterials,
characterized
by
ability
emulate
characteristics
cartilage,
offers
distinct
advantage
minimally
invasive
administration
directly
site
damage.
These
hydrogels
can
also
serve
as
ideal
delivery
vehicles
a
diverse
range
bioactive
agents,
including
growth
factors,
anti-inflammatory
drugs,
steroids,
cells.
controlled
release
such
biologically
active
molecules
hydrogel
scaffolds
accelerate
healing,
stimulate
chondrogenesis,
modulate
inflammatory
microenvironment
halt
progression.
present
review
aims
describe
methods
used
design
hydrogels,
expound
upon
applications
molecules,
provide
update
on
advances
leveraging
systems
foster
regeneration.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 28, 2023
Abstract
Zwitterionic
hydrogels
have
high
potential
for
cartilage
tissue
engineering
due
to
their
ultra‐hydrophilicity,
nonimmunogenicity,
and
superior
antifouling
properties.
However,
application
in
this
field
has
been
limited
so
far,
the
lack
of
injectable
zwitterionic
that
allow
encapsulation
cells
a
biocompatible
manner.
Herein,
novel
strategy
is
developed
engineer
employing
granular
are
injectable,
self‐healing,
situ
crosslinkable
direct
with
biocompatibility.
The
hydrogel
produced
by
mechanical
fragmentation
bulk
photocrosslinked
made
carboxybetaine
acrylamide
(CBAA),
or
mixture
CBAA
sulfobetaine
methacrylate
(SBMA).
microgels
enzymatically
using
horseradish
peroxidase,
quickly
stabilize
construct,
resulting
microporous
hydrogel.
Encapsulated
human
primary
chondrocytes
highly
viable
able
proliferate,
migrate,
produce
cartilaginous
extracellular
matrix
(ECM)
It
also
shown
increasing
porosity
incorporation
SBMA,
cell
proliferation
ECM
secretion
further
improved.
This
simple
scalable
method,
which
expanding
versatility
diverse
applications.
Biofabrication,
Год журнала:
2024,
Номер
16(2), С. 025004 - 025004
Опубликована: Янв. 4, 2024
Abstract
Foreign
body
response
(FBR)
is
a
pervasive
problem
for
biomaterials
used
in
tissue
engineering.
Zwitterionic
hydrogels
have
emerged
as
an
effective
solution
to
this
problem,
due
their
ultra-low
fouling
properties,
which
enable
them
effectively
inhibit
FBR
vivo
.
However,
no
versatile
zwitterionic
bioink
that
allows
high
resolution
extrusion
bioprinting
of
implants
has
thus
far
been
reported.
In
work,
we
introduce
simple,
novel
method
producing
microgel
bioink,
using
alginate
methacrylate
(AlgMA)
crosslinker
and
mechanical
fragmentation
fabrication
method.
Photocrosslinked
made
carboxybetaine
acrylamide
(CBAA)
sulfobetaine
(SBMA)
are
mechanically
fragmented
through
meshes
with
aperture
diameters
50
90
µ
m
produce
bioink.
The
bioinks
both
sizes
showed
excellent
rheological
properties
were
high-resolution
printing
objects
overhanging
features
without
requiring
support
structure
or
bath.
AlgMA
dual
role,
allowing
primary
photocrosslinking
the
bulk
hydrogel
well
secondary
ionic
crosslinking
produced
microgels,
quickly
stabilize
printed
construct
calcium
bath
microporous
scaffold.
Scaffolds
∼20%
porosity,
they
supported
viability
chondrogenesis
encapsulated
human
chondrocytes.
Finally,
meniscus
model
was
bioprinted,
demonstrate
bioink’s
versatility
at
large,
cell-laden
constructs
stable
further
vitro
culture
promote
cartilaginous
production.
This
easy
scalable
strategy
direct
cell
encapsulation
scaffold
potential
biocompatibility
nature
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Июнь 17, 2024
Abstract
Microgels
prepared
from
natural
or
synthetic
hydrogel
materials
have
aroused
extensive
attention
as
multifunctional
cells
drug
carriers,
that
are
promising
for
tissue
engineering
and
regenerative
medicine.
can
also
be
aggregated
into
microporous
scaffolds,
promoting
cell
infiltration
proliferation
repair.
This
review
gives
an
overview
of
recent
developments
in
the
fabrication
techniques
applications
microgels.
A
series
conventional
novel
strategies
including
emulsification,
microfluidic,
lithography,
electrospray,
centrifugation,
gas-shearing,
three-dimensional
bioprinting,
etc.
discussed
depth.
The
characteristics
microgels
microgel-based
scaffolds
culture
delivery
elaborated
with
emphasis
on
advantages
these
carriers
therapy.
Additionally,
we
expound
ongoing
foreseeable
current
limitations
their
aggregate
field
biomedical
engineering.
Through
stimulating
innovative
ideas,
present
paves
new
avenues
expanding
application
techniques.
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
45(11)
Опубликована: Фев. 24, 2024
Abstract
Hydrogels,
key
in
biomedical
research
for
their
hydrophilicity
and
versatility,
have
evolved
with
hydrogel
microspheres
(HMs)
of
micron‐scale
dimensions,
enhancing
role
minimally
invasive
therapeutic
delivery,
tissue
repair,
regeneration.
The
recent
emergence
nanomaterials
has
ushered
a
revolutionary
transformation
the
field,
which
demonstrates
tremendous
potential
targeted
therapies,
biological
imaging,
disease
diagnostics.
Consequently,
integration
advanced
nanotechnology
promises
to
trigger
new
revolution
realm
hydrogels.
HMs
loaded
combine
advantages
both
hydrogels
nanomaterials,
enables
multifaceted
functionalities
such
as
efficient
drug
sustained
release,
therapy,
lubrication,
biochemical
detection,
medical
biosensing
monitoring,
micro‐robotics.
Here,
this
review
comprehensively
expounds
upon
commonly
used
classifications.
Then,
it
provides
comprehensive
insights
into
raw
materials
preparation
methods
HMs.
Besides,
common
strategies
employed
achieve
nano‐micron
combinations
are
summarized,
latest
applications
these
combined
field
elucidated.
Finally,
valuable
future
design
development
provided.
Biofabrication,
Год журнала:
2024,
Номер
16(2), С. 025009 - 025009
Опубликована: Янв. 10, 2024
Three-dimensional
(3D)
bioprinting
embedded
within
a
microgel
bath
has
emerged
as
promising
strategy
for
creating
intricate
biomimetic
scaffolds.
However,
it
remains
great
challenge
to
construct
tissue-scale
structures
with
high
resolution
by
using
3D
due
the
large
particle
size
and
polydispersity
of
medium,
well
its
limited
cytocompatibility.
To
address
these
issues,
novel
uniform
sub-microgels
cell-friendly
cationic-crosslinked
kappa-carrageenan
(κ-Car)
are
developed
through
an
easy-to-operate
mechanical
grinding
strategy.
Theseκ-Car
maintain
submicron
around
642
nm
display
rapid
jamming-unjamming
transition
5
s,
along
excellent
shear-thinning
self-healing
properties,
which
critical
fidelity
in
construction
tissue
architecture
via
bioprinting.
Utilizing
this
new
sub-microgel
various
organ
structures,
including
heart,
lungs,
trachea,
branched
vasculature,
kidney,
auricle,
nose,
liver,
successfully
fabricated
delicate
fine
shape
fidelity.
Moreover,
bone
marrow
mesenchymal
stem
cells
encapsulated
printed
constructs
exhibit
remarkable
viability
exceeding
92.1%
robust
growth.
Thisκ-Car
medium
offers
innovative
avenue
achieving
high-quality
bioprinting,
facilitating
fabrication
functional
biological
structural
organizations.
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 20
Опубликована: Апрель 10, 2024
Drug
delivery
via
hydrogel
is
one
of
the
most
effective
methods.
Hydrogels
have
been
described
as
polymeric
water-swollen
materials
and
retain
water
in
distinctive
three-dimensional
complex.
These
are
classified
pH
sensitive
hydrogels,
temperature
homo-polymer
co-polymer
hydrogels
Interpenetrating
Network
(IP-N)
hydrogel.
can
be
prepared
various
techniques,
including
physical
crosslinking,
chemical
free
radical
polymerization,
photo-initiator's
hydrogen
bonding.
Various
polymers
manufacturing
includes
pectin,
chitosan,
cyclodextrin
carrageenan,
etc.
This
review
aims
to
describes
for
drug
delivery,
classifications,
preparation
highlights
novel
applications
medicine.
