Gels,
Год журнала:
2024,
Номер
10(9), С. 569 - 569
Опубликована: Авг. 31, 2024
Chinese
herbs
are
a
huge
treasure
trove
of
natural
products
and
an
important
source
many
active
molecules.
The
theory
traditional
medicine
compatibility
(TCMC)
is
widely
applied
in
clinical
practice,
but
its
mechanism
still
ambiguous.
This
study
aims
to
open
new
window
for
this
predicament
by
studying
the
interaction
between
main
ingredients
from
drug
pair.
Carrier-free
assembly
improves
shortcomings
nanodelivery
systems
opens
path
development
nanomaterials.
pair
"
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 21, 2024
Novel
biomaterials
are
becoming
more
crucial
in
treating
human
diseases.
However,
many
materials
require
complex
artificial
modifications
and
synthesis,
leading
to
potential
difficulties
preparation,
side
effects,
clinical
translation.
Recently,
significant
progress
has
been
achieved
terms
of
direct
self-assembly
natural
products
from
herbal
medicine
(NPHM),
an
important
source
for
novel
medications,
resulting
a
wide
range
bioactive
supramolecular
including
gels,
nanoparticles.
The
NPHM-based
produced
renewable
resources,
simple
prepare,
have
demonstrated
multi-functionality
slow-release,
smart-responsive
release,
especially
possess
powerful
biological
effects
treat
various
In
this
review,
revealed
as
emerging,
revolutionary,
promising
strategy.
development,
advantages,
limitations
NPHM,
well
the
advantageous
position
materials,
first
reviewed.
Subsequently,
systematic
comprehensive
analysis
strategies
specific
seven
major
classes
NPHM
is
highlighted.
Insights
into
influence
structural
features
on
formation
also
provided.
Finally,
drivers
preparations
summarized,
emphasizing
biomedical
applications,
future
scientific
challenges,
opportunities,
with
hope
igniting
inspiration
research
applications.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Март 3, 2024
Abstract
Curcumin,
a
natural
bioactive
polyphenol
with
diverse
molecular
targets,
is
well
known
for
its
anti‐oxidation
and
anti‐inflammatory
potential.
However,
curcumin
exhibits
low
solubility
(<1
µg
mL
−1
),
poor
tissue‐targeting
ability,
rapid
oxidative
degradation,
resulting
in
bioavailability
stability
inflammatory
therapy.
Here,
poly(diselenide‐oxalate‐curcumin)
nanoparticle
(SeOC‐NP)
dual‐reactive
oxygen
species
(ROS)
sensitive
chemical
moieties
(diselenide
peroxalate
ester
bonds)
fabricated
by
one‐step
synthetic
strategy.
The
results
confirmed
that
dual‐ROS
endowed
SeOC‐NP
the
ability
of
targeted
delivery
significantly
suppress
degradation
high‐efficiency
In
detail,
amount
SeOC
about
4‐fold
lower
than
free
an
microenvironment.
As
result,
enhanced
antioxidant
activity
efficacy
vitro
analysis
scavenging
intracellular
ROS
suppressing
secretion
nitric
oxide
pro‐inflammatory
cytokines.
mouse
colitis
models,
orally
administered
can
remarkably
alleviate
symptoms
IBD
maintain
homeostasis
gut
microbiota.
This
work
provided
simple
effective
strategy
to
fabricate
ROS‐responsive
micellar
enhance
oxidation
medicine
precise
therapeutic
inflammation.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 1, 2024
Abstract
Background
Herbal
nanoparticles
are
made
from
natural
herbs/medicinal
plants,
their
extracts,
or
a
combination
with
other
nanoparticle
carriers.
Compared
to
traditional
herbs,
herbal
lead
improved
bioavailability,
enhanced
stability,
and
reduced
toxicity.
Previous
research
indicates
that
medicine
nanomaterials
rapidly
advancing
making
significant
progress;
however,
bibliometric
analysis
knowledge
mapping
for
currently
lacking.
We
performed
by
retrieving
publications
related
the
Web
of
Science
Core
Collection
(WoSCC)
database
spanning
2004
2023.
Data
processing
was
using
R
package
Bibliometrix,
VOSviewers,
CiteSpace.
Results
In
total,
1876
articles
were
identified,
originating
various
countries,
China
being
primary
contributing
country.
The
number
in
this
field
increases
annually.
Beijing
University
Chinese
Medicine,
Shanghai
Traditional
Saveetha
India
prominent
institutions
domain.
Journal
“International
Nanomedicine”
has
highest
publications.
authors
these
reached
8234,
Yan
Zhao,
Yue
Zhang,
Huihua
Qu
most
prolific
Zhao
frequently
cited
author.
“Traditional
medicine,”
“drug
delivery,”
“green
synthesis”
main
focal
points.
Themes
such
as
synthesis,”
“curcumin,”
“wound
healing,”
“carbon
dots”
may
represent
emerging
areas.
Conclusions
Our
study
findings
assist
identifying
latest
frontiers
hot
topics,
providing
valuable
references
scholars
investigating
role
nanotechnology
medicine.
Graphical
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 12, 2024
Abstract
Treatment
for
inflammatory
bowel
disease
(IBD)
is
challenging
since
current
anti-inflammatory
and
immunosuppressive
therapies
do
not
address
the
underlying
causes
of
illness,
which
include
increased
levels
reactive
oxygen
species
(ROS)
dysbiosis
gut
commensal
microbiota.
Additionally,
these
treatments
often
have
systemic
off-target
effects
adverse
side
effects.
In
this
study,
we
developed
a
prebiotic
yeast
β-glucan
nanocomplex
coated
with
bio-adhesive
polydopamine
(YBNs@PDA)
to
effectively
prolong
their
retention
time
in
gastrointestinal
(GI)
tract.
The
oral
administration
YBNs@PDA
restored
epithelium
barriers,
reduced
ROS
levels,
minimized
drug
exposure
while
improved
therapeutic
efficacy
an
acute
colitis
mouse
model.
Furthermore,
16S
ribosomal
RNA
genes
sequencing
demonstrated
higher
richness
diversity
microflora
composition
following
treatments.
particular,
markedly
augmented
abundance
Lachnospiraceae
NK4A136
Bifidobacterium
,
both
are
probiotics
crucial
roles
relieving
via
retaining
homeostasis.
Cumulatively,
results
demonstrate
that
potential
as
novel
drug-free,
ROS-scavenging
microbiota
regulation
nanoplatform
treatment
GI
disorders.
ACS Nano,
Год журнала:
2024,
Номер
18(35), С. 23827 - 23841
Опубликована: Авг. 20, 2024
Carrier-free
nanodrugs
with
extraordinary
active
pharmaceutical
ingredient
(API)
loading
(even
100%),
avoidable
carrier-induced
toxicity,
and
simple
synthetic
procedures
are
considered
as
one
of
the
most
promising
candidates
for
disease
theranostics.
Substantial
studies
commercial
success
"carrier-free"
nanocrystals
have
demonstrated
their
strong
clinical
potential.
However,
practical
translations
remain
challenging
impeded
by
unpredictable
assembly
processes,
insufficient
delivery
efficiency,
an
unclear
in
vivo
fate.
In
this
Perspective,
we
systematically
outline
contemporary
emerging
carrier-free
based
on
diverse
APIs,
well
highlight
opportunities
challenges
translation.
Looking
ahead,
further
improvements
design
preparation,
drug
delivery,
efficacy,
safety
nanomedicines
essential
to
facilitate
translation
from
bench
bedside.
