ACS Nano,
Год журнала:
2022,
Номер
16(7), С. 10066 - 10087
Опубликована: Июль 1, 2022
Antibiotic
resistance
has
become
a
serious
threat
to
human
health
due
the
overuse
of
antibiotics.
Different
antibiotics
are
being
developed
treat
resistant
bacteria,
but
development
cycle
is
hard
keep
up
with
high
incidence
antibiotic
resistance.
Recent
advances
in
antimicrobial
nanomaterials
have
made
nanotechnology
powerful
solution
this
dilemma.
Among
these
nanomaterials,
gold
excellent
antibacterial
efficacy
and
biosafety,
making
them
alternatives
This
review
presents
strategies
that
use
combat
drug-resistant
bacteria.
We
focus
on
influence
physicochemical
factors
such
as
surface
chemistry,
size,
shape
their
properties
describe
applications
medical
devices.
Finally,
existing
challenges
future
directions
discussed.
Chemical Reviews,
Год журнала:
2022,
Номер
122(23), С. 17073 - 17154
Опубликована: Окт. 6, 2022
The
term
"zwitterionic
polymers"
refers
to
polymers
that
bear
a
pair
of
oppositely
charged
groups
in
their
repeating
units.
When
these
are
equally
distributed
at
the
molecular
level,
molecules
exhibit
an
overall
neutral
charge
with
strong
hydration
effect
via
ionic
solvation.
constitutes
foundation
series
exceptional
properties
zwitterionic
materials,
including
resistance
protein
adsorption,
lubrication
interfaces,
promotion
stabilities,
antifreezing
solutions,
etc.
As
result,
materials
have
drawn
great
attention
biomedical
and
engineering
applications
recent
years.
In
this
review,
we
give
comprehensive
panoramic
overview
covering
fundamentals
nonfouling
behaviors,
different
types
surfaces
polymers,
applications.
Frontiers in Pharmacology,
Год журнала:
2021,
Номер
12
Опубликована: Фев. 3, 2021
Advances
in
nanotechnology
have
favored
the
development
of
novel
colloidal
formulations
able
to
modulate
pharmacological
and
biopharmaceutical
properties
drugs.
The
peculiar
physico-chemical
technological
nanomaterial-based
therapeutics
allowed
for
several
successful
applications
treatment
cancer.
size,
shape,
charge
patterning
nanoscale
therapeutic
molecules
are
parameters
that
need
be
investigated
modulated
order
promote
optimize
cell
tissue
interaction.
In
this
review,
use
polymeric
nanoparticles
as
drug
delivery
systems
anticancer
compounds,
their
ability
efficiently
localized
specific
tumor
tissues
been
described.
nanoencapsulation
antitumor
active
compounds
is
a
promising
approach
improve
efficacy
various
treatments.
Exploration,
Год журнала:
2021,
Номер
1(1), С. 75 - 89
Опубликована: Авг. 1, 2021
As
the
next
generation
of
artificial
enzymes,
nanozymes
have
shown
unique
properties
compared
to
its
natural
counterparts,
such
as
stability
in
harsh
environment,
low
cost,
and
ease
production
modification,
paving
way
for
biomedical
applications.
Among
them,
tumor
catalytic
therapy
mediated
by
reactive
oxygen
species
(ROS)
has
made
great
progress
mainly
from
peroxidase-like
activity
nanozymes.
Fe
Journal of Nanobiotechnology,
Год журнала:
2021,
Номер
19(1)
Опубликована: Май 29, 2021
Abstract
In
this
article,
we
will
describe
the
properties
of
albumin
and
its
biological
functions,
types
sources
that
can
be
used
to
produce
nanoparticles,
methods
producing
therapeutic
applications
importance
nanoparticles
in
production
pharmaceutical
formulations.
view
increasing
use
Abraxane
approval
for
treatment
several
cancer
during
final
stages
clinical
trials
other
cancers,
evaluate
it
compare
effectiveness
with
conventional
non
formulations
chemotherapy
Paclitaxel
is
paid.
examine
role
animal
proteins
Nano
medicine
various
benefits
these
biomolecules
preparation
drug
delivery
carriers
characteristics
plant
protein
cages
their
potentials
diagnosis
treatment.
Finally,
advantages
disadvantages
are
mentioned,
as
well
Proceedings of the National Academy of Sciences,
Год журнала:
2022,
Номер
119(8)
Опубликована: Фев. 16, 2022
Significance
The
current
application
of
messenger
RNA
(mRNA)-based
technology
has
largely
been
confined
to
liver
diseases
because
the
lack
a
specific
and
efficient
extrahepatic
in
vivo
systemic
mRNA
delivery
system.
Here,
we
have
developed
library
N-series
lipid
nanoparticles
(LNPs)
that
could
specifically
regulate
protein
composition
corona
on
surface
LNPs,
which
allows
lung.
We
further
demonstrated
our
lung-targeting
LNP
effectively
deliver
mouse
tuberous
sclerosis
complex
2
(
Tsc2
)
into
TSC2-null
cells
restore
its
function,
resulting
enhanced
control
tumor
burden
preclinical
model
lymphangioleiomyomatosis,
destructive
lung
disease
caused
by
loss-of-function
mutations
gene.
Abstract
Reactive
oxygen
species
(ROS)
play
an
essential
role
in
physiological
and
pathological
processes.
Studies
on
the
regulation
of
ROS
for
disease
treatments
have
caused
wide
concern,
mainly
involving
topics
ROS‐regulating
therapy
such
as
antioxidant
triggered
by
scavengers
ROS‐induced
toxic
mediated
ROS‐elevation
agents.
Benefiting
from
remarkable
advances
nanotechnology,
a
large
number
nanomaterials
with
ability
are
developed
to
seek
new
effective
ROS‐related
nanotherapeutic
modalities
or
nanomedicines.
Although
considerable
achievements
been
made
ROS‐based
nanomedicines
treatments,
some
fundamental
but
key
questions
rational
design
principle
held
low
regard.
Here,
can
serve
initial
framework
scientists
technicians
optimize
nanomedicines,
thereby
minimizing
gap
biomedical
application
during
stage.
Herein,
overview
current
progress
ROS‐associated
is
summarized.
And
then,
particularly
addressing
these
known
strategies
therapy,
several
principles
presented.
Finally,
future
perspectives
also
discussed
depth
development
