Lab on a Chip, Journal Year: 2023, Volume and Issue: 23(6), P. 1432 - 1466
Published: Jan. 1, 2023
Representation of the influence biological and nanoscale factors on protein corona conformation function in a healthy versus pathogenic environment.
Language: Английский
Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12
Published: Feb. 3, 2021
Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate pharmacological and biopharmaceutical properties drugs. The peculiar physico-chemical technological nanomaterial-based therapeutics allowed for several successful applications treatment cancer. size, shape, charge patterning nanoscale therapeutic molecules are parameters that need be investigated modulated order promote optimize cell tissue interaction. In this review, use polymeric nanoparticles as drug delivery systems anticancer compounds, their ability efficiently localized specific tumor tissues been described. nanoencapsulation antitumor active compounds is a promising approach improve efficacy various treatments.
Language: Английский
Citations
405
Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(23), P. 17073 - 17154
Published: Oct. 6, 2022
The term "zwitterionic polymers" refers to polymers that bear a pair of oppositely charged groups in their repeating units. When these are equally distributed at the molecular level, molecules exhibit an overall neutral charge with strong hydration effect via ionic solvation. constitutes foundation series exceptional properties zwitterionic materials, including resistance protein adsorption, lubrication interfaces, promotion stabilities, antifreezing solutions, etc. As result, materials have drawn great attention biomedical and engineering applications recent years. In this review, we give comprehensive panoramic overview covering fundamentals nonfouling behaviors, different types surfaces polymers, applications.
Language: Английский
Citations
394
Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(9), P. 766 - 783
Published: May 19, 2021
Language: Английский
Citations
364
Exploration, Journal Year: 2021, Volume and Issue: 1(1), P. 75 - 89
Published: Aug. 1, 2021
As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease production modification, paving way for biomedical applications. Among them, tumor catalytic therapy mediated by reactive oxygen species (ROS) has made great progress mainly from peroxidase-like activity nanozymes. Fe
Language: Английский
Citations
342
Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)
Published: May 29, 2021
Abstract In this article, we will describe the properties of albumin and its biological functions, types sources that can be used to produce nanoparticles, methods producing therapeutic applications importance nanoparticles in production pharmaceutical formulations. view increasing use Abraxane approval for treatment several cancer during final stages clinical trials other cancers, evaluate it compare effectiveness with conventional non formulations chemotherapy Paclitaxel is paid. examine role animal proteins Nano medicine various benefits these biomolecules preparation drug delivery carriers characteristics plant protein cages their potentials diagnosis treatment. Finally, advantages disadvantages are mentioned, as well
Language: Английский
Citations
325
Materials Today, Journal Year: 2020, Volume and Issue: 37, P. 112 - 125
Published: March 4, 2020
Language: Английский
Citations
316
Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(8)
Published: Feb. 16, 2022
Significance The current application of messenger RNA (mRNA)-based technology has largely been confined to liver diseases because the lack a specific and efficient extrahepatic in vivo systemic mRNA delivery system. Here, we have developed library N-series lipid nanoparticles (LNPs) that could specifically regulate protein composition corona on surface LNPs, which allows lung. We further demonstrated our lung-targeting LNP effectively deliver mouse tuberous sclerosis complex 2 ( Tsc2 ) into TSC2-null cells restore its function, resulting enhanced control tumor burden preclinical model lymphangioleiomyomatosis, destructive lung disease caused by loss-of-function mutations gene.
Language: Английский
Citations
315
Advanced Science, Journal Year: 2020, Volume and Issue: 8(3)
Published: Dec. 20, 2020
Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development
Language: Английский
Citations
271
Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 101008 - 101008
Published: Oct. 21, 2020
Language: Английский
Citations
218
Nature Nanotechnology, Journal Year: 2021, Volume and Issue: 16(6), P. 708 - 716
Published: Feb. 18, 2021
Language: Английский
Citations
207