ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 15072 - 15085
Опубликована: Авг. 15, 2022
Nanosized
artificial
antigen-presenting
cells
(aAPCs),
synthetic
immune
cell
mimics
that
aim
to
activate
T
ex
or
in
vivo,
offer
an
effective
alternative
cellular
immunotherapies.
However,
comprehensive
studies
delineate
the
effect
of
nano-aAPC
topology,
including
nanoparticle
morphology
and
ligand
density,
are
lacking.
Here,
we
systematically
studied
topological
effects
polymersome-based
aAPCs
on
activation.
We
employed
aAPC
library
created
from
biodegradable
poly(ethylene
glycol)-block-poly(d,l-lactide)
(PEG-PDLLA)
polymersomes
with
spherical
tubular
shape
variable
sizes,
which
were
functionalized
αCD3
αCD28
antibodies
at
controlled
densities.
Our
results
indicate
high
density
leads
enhancement
activation,
can
be
further
augmented
by
employing
larger
size.
At
low
both
polymersome
size
was
more
pronounced,
showing
large
elongated
better
compared
their
smaller
counterparts.
This
study
demonstrates
capacity
as
highlights
role
topology
for
rational
design.
ACS Nano,
Год журнала:
2024,
Номер
18(10), С. 7644 - 7655
Опубликована: Фев. 27, 2024
Engineering
exosomes
with
nanomaterials
usually
leads
to
the
damage
of
exosomal
membrane
and
bioactive
molecules.
Here,
pathological
angiogenesis
targeting
magnetic
imaging,
ferroptosis
inducing,
immunotherapeutic
properties
is
fabricated
using
a
simple
coincubation
method
macrophages
being
bioreactor.
Extremely
small
iron
oxide
nanoparticle
(ESIONPs)
incorporated
(ESIONPs@EXO)
are
acquired
by
sorting
secreted
from
M1-polarized
induced
ESIONPs.
ESIONPs@EXO
suppress
in
vitro
vivo
without
toxicity.
Furthermore,
target
exhibit
an
excellent
T1-weighted
contrast
property
for
resonance
imaging.
Mechanistically,
induce
ability
toward
angiogenesis.
These
findings
demonstrate
that
pure
biological
engineered
shows
potential
targeted
therapy.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
61(8)
Опубликована: Дек. 20, 2021
Protease
inhibitors
can
modulate
intratumoral
metabolic
processes
to
reprogram
the
immunosuppressive
tumor
microenvironment
(TME),
which
however
suffer
from
limited
efficacy
and
off-targeted
side
effects.
We
report
smart
nano-proteolysis
targeting
chimeras
(nano-PROTACs)
with
phototherapeutic
ablation
cancer-specific
protein
degradation
TME
for
photo-metabolic
cancer
immunotherapy.
This
nano-PROTAC
has
a
semiconducting
polymer
backbone
linked
cyclooxygenase
1/2
(COX-1/2)-targeting
PROTAC
peptide
(CPP)
via
cathepsin
B
(CatB)-cleavable
segment.
CPP
be
activated
by
tumor-overexpressed
CatB
induce
of
COX-1/2
ubiquitin-proteasome
system.
The
persistent
depletes
their
metabolite
prostaglandin
E2
is
responsible
activation
immune
suppressor
cells.
Such
strategy
synergized
phototherapy
specifically
reprograms
reinvigorates
antitumor
immunity.
Advanced Materials,
Год журнала:
2021,
Номер
34(46)
Опубликована: Дек. 8, 2021
Multiple
myeloma
(MM)
is
the
second
most
common
hematological
malignancy.
It
characterized
by
abnormal
transformation
and
uncontrolled
clonal
proliferation
of
malignant
plasma
cells
in
bone
marrow
(BM),
which
can
destroy
structure
inhibit
hematopoiesis.
Although
there
are
new
therapeutic
methods,
they
not
curative,
mainly
because
it
difficult
to
deliver
an
effective
amount
drug
BM,
leading
a
failure
eradicate
MM
inside
BM.
BM
homing
important
unique
characteristic
affected
surface
molecules
on
tumor
cell
membrane.
Inspired
this
mechanism,
MM-mimicking
nanocarrier
developed
coating
bortezomib
(BTZ)-loaded
poly(ε-caprolactone)-poly(ethylene
glycol)-poly(ε-caprolactone)
(PCEC)
nanoparticles
with
The
enter
based
as
"Trojan
horse"
target
through
homologous
targeting.
In
way,
availability
at
site
enhanced
so
growth.
addition,
these
escape
phagocytosis
MPS
have
long
circulation
effect.
vivo
results
demonstrate
excellent
treatment
efficacy
for
MM.
Accordingly,
strategy
may
be
promising
platform
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
61(10)
Опубликована: Дек. 30, 2021
Combination
photoimmunotherapy
holds
promise
for
tumor
suppression;
however,
smart
phototherapeutic
agents
that
only
activate
their
immune
pharmaceutical
action
in
tumors
have
been
rarely
developed.
Herein,
we
report
a
semiconducting
polymer
(SP)
nano-regulator
(SPNT
)
with
cascading
activation
combinational
photodynamic
cancer
immunotherapy.
SPNT
comprises
an
immunoregulator
(M-Trp:
1-methyltryptophan)
conjugating
to
the
side
chain
of
SP
backbone
via
apoptotic
biomarker-cleavable
linker.
Under
near-infrared
photoirradiation,
produces
singlet
oxygen
induce
immunogenic
apoptosis.
Concurrently,
biomarker
is
upregulated,
which
triggers
specific
cleavage
M-Trp
indoleamine
2,3-dioxygenase
(IDO)
activity
inhibition,
regulatory
T
cells
reduction
and
cytotoxic
lymphocytes
infiltration.
-mediated
combination
immunotherapy
thus
reprograms
microenvironment,
resulting
efficient
suppression
tumors,
inhibition
lung
metastasis.
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(29)
Опубликована: Апрель 27, 2022
Abstract
The
synergistic
efficacy
of
phototherapy
and
cancer
immunotherapy
is
severely
restricted
by
both
the
inherent
photobleaching
aggregation‐caused
quench
(ACQ)
defects
photosensitizers
intrinsic
antioxidant
tumor
microenvironment
(TME),
such
as
hypoxia
overexpressed
glutathione
(GSH).
To
address
these
issues,
a
novel
porphyrin‐based
staggered
stacking
covalent
organic
framework
(COF),
COF‐618‐Cu,
rationally
designed
reactive
oxygen
species
(ROS)
amplifier,
owing
to
its
excellent
catalase‐like
activity,
COF‐618‐Cu
capable
consuming
endogenous
hydrogen
peroxide
produce
sufficient
alleviate
phenomena.
Moreover
intracellular
GSH
also
depleted
decrease
scavenging
ROS,
due
peroxidase
mimic
activity
COF‐618‐Cu.
Mechanistic
studies
reveal
that
unique
mode
between
interlayers
can
effectively
relieve
ACQ
effects
are
inaccessible
commonly
eclipsed
COFs.
These,
combined
with
their
photothermal
therapy
performance,
make
favorable
for
inducing
robust
immunogenic
cell
death
remodeling
TME
boost
antitumor
immunity.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Фев. 5, 2022
Abstract
Chemodynamic
therapy
(CDT)
based
on
Fenton
or
Fenton-like
reactions
is
an
emerging
cancer
treatment
that
can
both
effectively
fight
and
reduce
side
effects
normal
cells
tissues,
it
has
made
important
progress
in
treatment.
The
catalytic
efficiency
of
nanocatalysts(F-NCs)
directly
determines
the
anticancer
effect
CDT.
To
learn
more
about
this
new
type
therapy,
review
summarizes
recent
development
F-NCs
are
responsive
to
tumor
microenvironment
(TME),
detailedly
introduces
their
material
design
action
mechanism.
Based
deficiencies
them,
some
effective
strategies
significantly
improve
efficacy
highlighted,
which
mainly
includes
increasing
temperature
hydrogen
peroxide
concentration,
reducing
pH,
glutathione
(GSH)
content,
dependence
acidic
environment
TME.
It
also
discusses
differences
between
multi-mode
with
external
energy
(light
ultrasound)
single-mode
Finally,
challenges
encountered
process,
future
direction
F-NCs,
suggestions
analyzed
promote
CDT
enter
clinical
stage
near
future.
Graphical
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(50)
Опубликована: Окт. 18, 2022
The
performances
of
second
near-infrared
(NIR-II)
organic
phototheranostic
agents
(OPTAs)
depend
on
both
molecular
structure
and
packing
when
used
as
nanoparticles
(NPs).
Herein,
we
proposed
a
facile
structural
isomerization-induced
3D
spatial
donor
(D)-acceptor
(A)
interlocked
network
for
achieving
NIR-II
OPTAs.
Two
isomers,
4MNVDPP
6MNVDPP
were
synthesized
formulated
into
NPs.
6MNVDPP,
which
has
larger
electrostatic
potential
difference,
exhibits
compact
D-A
in
the
crystal
form,
while
forms
2D
D-D
type
J-aggregates.
Thus,
NPs
show
red-shifted
NIR
absorption
molar
extinction
coefficient
than
Thanks
to
typical
emission,
superior
photothermal-stability,
high
photothermal
conversion
efficiency
(89
%)
reactive
oxygen
species
production
capacity,
exhibit
outstanding
tiny
capillary
vasculature/tumor
imaging
ability
synergistic
photothermal/photodynamic
anti-cancer
effect
vivo.
