Erythrocyte−cancer hybrid membrane-coated reduction-sensitive nanoparticles for enhancing chemotherapy efficacy in breast cancer DOI Creative Commons
Somayeh Rezaei, Raimundo Fernandes de Araújo Júnior,

Isadora Luisa Gomes da Silva

и другие.

Biomaterials Advances, Год журнала: 2023, Номер 151, С. 213456 - 213456

Опубликована: Май 10, 2023

Cell-membrane-coated biomimetic nanoparticles (NPs) have attracted great attention due to their prolonged circulation time, immune escape mechanisms and homotypic targeting properties. Biomimetic nanosystems from different types of cell -membranes (CMs) can perform increasingly complex tasks in dynamic biological environments thanks specific proteins other properties inherited the source cells. Herein, we coated doxorubicin (DOX)-loaded reduction-sensitive chitosan (CS) NPs with 4T1 cancer (CCMs), red blood (RBCMs) hybrid erythrocyte-cancer membranes (RBC-4T1CMs) enhance delivery DOX breast The physicochemical (size, zeta potential morphology) resulting RBC@DOX/CS-NPs, 4T1@DOX/CS-NPs RBC-4T1@DOX/CS-NPs, as well cytotoxic effect cellular NP uptake vitro were thoroughly characterized. anti-cancer therapeutic efficacy was evaluated using orthotopic model vivo. experimental results showed that DOX/CS-NPs had a DOX-loading capacity 71.76 ± 0.87 %, coating 4T1CM significantly increased Interestingly, by optimizing ratio RBCMs:4T1CMs, it possible increase towards Moreover, vivo tumor studies compared control free DOX, both RBC@DOX/CS-NPs inhibited growth metastasis. However, more prominent. CM-coating reduced macrophages led rapid clearance liver lungs vivo, NPs. Our suggest self-recognition cells In conclusion, tumor-disguised CM-coated exhibited properties, superior over RBC-CM or RBC-4T1 membranes, suggesting presence 4T1-CM is critical for treatment outcome.

Язык: Английский

Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis DOI
Ronghui Deng, Ruifang Zhao, Zining Zhang

и другие.

Science Translational Medicine, Год журнала: 2024, Номер 16(735)

Опубликована: Фев. 21, 2024

Osteoarthritis (OA) is a chronic joint disease characterized by progressive degeneration of articular cartilage. A challenge in the development disease-modifying drugs effective delivery to chondrocytes. The unique structure promotes rapid clearance through synovial fluid, and dense avascular cartilage extracellular matrix (ECM) limits drug penetration. Here, we show that poly(lactide- co -glycolic acid) nanoparticles coated chondrocyte membranes (CM-NPs) were preferentially taken up rat chondrocytes ex vivo compared with uncoated nanoparticles. Internalization CM-NPs was mediated primarily E-cadherin, clathrin-mediated endocytosis, micropinocytosis. These adhered ECM knee joints penetrated deeply into residence time more than 34 days. Simulated fluid studies showed loaded Wnt pathway inhibitor, adavivint (CM-NPs-Ada), delayed catabolic metabolism human explants under inflammatory conditions. In surgical model OA, drug-loaded effectively restored gait, attenuated periarticular bone remodeling, provided chondroprotection against degeneration. OA progression also mitigated CM-NPs-Ada canine anterior cruciate ligament transection. results demonstrate feasibility using membrane–coated improve pharmacokinetics efficacy anti-OA drugs.

Язык: Английский

Процитировано

45
Innovative utilization of cell membrane‐coated nanoparticles in precision cancer therapy DOI Creative Commons
Yiling He, Shuquan Zhang,

Yaoguang She

и другие.

Exploration, Год журнала: 2024, Номер 4(6)

Опубликована: Март 21, 2024

Abstract Cell membrane‐coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. By encapsulating therapeutic agents within cell membrane‐derived coating, these combine the advantages of synthetic and natural membranes. This review provides comprehensive overview recent advancements in utilizing CMNPs effective drug delivery vehicles The synthesis fabrication methods are comprehensively discussed. Various techniques, such extrusion, sonication, self‐assembly, employed to coat with membranes derived from different types. membrane coating enables biocompatibility, reducing risk an immune response enhancing stability bloodstream. Moreover, functionalization strategies CMNPs, primarily chemical modification, genetic engineering, external stimuli, highlighted. presence specific surface markers on coated allows targeted cells maximizes efficacy. Preclinical studies therapy demonstrated successful various agents, chemotherapeutic drugs, nucleic acids, immunotherapeutic using CMNPs. Furthermore, article explores future directions challenges this technology while offering insights into its clinical potential.

Язык: Английский

Процитировано

33
Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

и другие.

MedComm – Oncology, Год журнала: 2024, Номер 3(1)

Опубликована: Март 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Язык: Английский

Процитировано

32
Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform DOI Creative Commons

Qiuyan Guo,

Shengmei Wang,

Rubing Xu

и другие.

RSC Advances, Год журнала: 2024, Номер 14(15), С. 10608 - 10637

Опубликована: Янв. 1, 2024

This review summarized the function of cancer cell membranes and comprehensively discussed preparation membrane-coated nanoparticles (CCM-NPs) their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).

Язык: Английский

Процитировано

21
Cell Membrane-derived Nanovesicles as Extracellular Vesicle-mimetics in Wound Healing DOI Creative Commons
Wen Li, Huihui Zhang, Lianglong Chen

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101595 - 101595

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

5
Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy DOI Creative Commons
Yuemin Wang, Duan Wang, Yuyue Zhang

и другие.

Bioactive Materials, Год журнала: 2022, Номер 22, С. 239 - 253

Опубликована: Окт. 7, 2022

Chemodynamic therapy (CDT), a noninvasive strategy, has emerged as promising alternative to conventional chemotherapy for treating tumors. However, its therapeutic effect is limited by the amount of H2O2, pH value, hypoxic environment tumors, and it suboptimal tumor-targeting ability. In this study, tumor cell membrane-camouflaged mesoporous Fe3O4 nanoparticles loaded with perfluoropentane (PFP) glucose oxidase (GOx) are used microenvironment-adaptive nanoplatform ([email protected]2-G), which synergistically enhances antitumor CDT. Mesoporous selected inducers photothermal Fenton reactions nanocarriers. GOx depletes within cells starving cells, while producing H2O2 subsequent ·OH generation. Moreover, PFP, can carry O2, relieves hypoxia in provides O2 cascade reaction. Finally, camouflaged osteosarcoma membranes, endowing homologous targeting immune escape abilities. Both vivo vitro evaluations reveal high synergistic efficacy [email protected]2-G, desirable tumor-inhibition rate (90.50%), indicates great potential platform clinical cancer.

Язык: Английский

Процитировано

56
In situ photothermal nano-vaccine based on tumor cell membrane-coated black phosphorus-Au for photo-immunotherapy of metastatic breast tumors DOI

Deqiu Huang,

Tong Wu,

Siyuan Lan

и другие.

Biomaterials, Год журнала: 2022, Номер 289, С. 121808 - 121808

Опубликована: Сен. 16, 2022

Язык: Английский

Процитировано

45
Bone‐Targeted Biomimetic Nanogels Re‐Establish Osteoblast/Osteoclast Balance to Treat Postmenopausal Osteoporosis DOI
Yongzhi Cui,

Bin Lv,

Zhongying Li

и другие.

Small, Год журнала: 2023, Номер 20(6)

Опубликована: Окт. 4, 2023

Abstract Insufficient bone formation and excessive resorption caused by estrogen deficiency are the major factors resulting in incidence of postmenopausal osteoporosis (PMOP). The existing drugs usually fail to re‐establish osteoblast/osteoclast balance from both sides generate side‐effects owing lack bone‐targeting ability. Here, engineered cell‐membrane‐coated nanogels PNG@mR&C capable scavenging receptor activator nuclear factor‐κB ligand (RANKL) responsively releasing therapeutic PTH 1–34 microenvironment prepared RANK CXCR4 overexpressed mesenchymal stem cell (BMSC) membrane‐coated chitosan biopolymers. on coated‐membranes confer ability, abundant effectively absorb RANKL inhibit osteoclastogenesis. Meanwhile, release triggered osteoclast‐mediated acid promote osteogenesis. In addition, dose frequency greatly reduced due smart property, prolonged circulation time, bone‐specific accumulation. Thus, exhibits satisfactory effects ovariectomized (OVX) mouse model. This study provides a new paradigm re‐establishing metabolic homeostasis multitargets shows great promise for treatment PMOP.

Язык: Английский

Процитировано

36
Cancer Immunotherapy Based on Cell Membrane‐Coated Nanocomposites Augmenting cGAS/STING Activation by Efferocytosis Blockade DOI
Zhian Chen, Zhenhao Li, Huilin Huang

и другие.

Small, Год журнала: 2023, Номер 19(43)

Опубликована: Июнь 28, 2023

Innate immunity triggered by the cGAS/STING pathway has potential to improve cancer immunotherapy. Previously, authors reported that double-stranded DNA (dsDNA) released dying tumor cells can trigger pathway. However, owing efferocytosis, are engulfed and cleared before damaged dsDNA is released; hence, immunologic tolerance immune escape occur. Herein, a cancer-cell-membrane biomimetic nanocomposites exhibit tumor-immunotherapeutic effects synthesized augmenting suppressing efferocytosis. Once internalized cells, combined chemo/chemodynamic therapy would be triggered, which damages their nuclear mitochondrial DNA. Furthermore, releasing Annexin A5 protein could inhibit efferocytosis effect promote immunostimulatory secondary necrosis preventing phosphatidylserine exposure, resulting in burst release of dsDNA. These fragments, as molecular patterns immunogenic damage, from activate pathway, enhance cross-presentation inside dendritic M1-polarization tumor-associated macrophages. In vivo experiments suggest proposed nanocomposite recruit cytotoxic T-cells facilitate long-term immunological memory. Moreover, when with immune-checkpoint blockades, it augment response. Therefore, this novel promising strategy for generating adaptive antitumor responses.

Язык: Английский

Процитировано

33
Review on Bortezomib Resistance in Multiple Myeloma and Potential Role of Emerging Technologies DOI Creative Commons
Gül Kozalak, İsmail Bütün, Erçil Toyran

и другие.

Pharmaceuticals, Год журнала: 2023, Номер 16(1), С. 111 - 111

Опубликована: Янв. 12, 2023

Multiple myeloma is a hematological cancer type. For its treatment, Bortezomib has been widely used. However, drug resistance to this effective chemotherapeutic developed for various reasons. 2D cell cultures and animal models have failed understand the MM disease resistance. It therefore essential utilize new technologies reveal complete molecular profile of disease. In review, we in-depth examined possible mechanisms that cause specifically addressed Moreover, also included use nanoparticles, 3D culture methods, microfluidics, organ-on-chip devices in multiple myeloma. We discussed whether emerging technology offers necessary tools prevent Despite ongoing research activities on MM, related studies cannot provide summary MM. Nanoparticle culturing frequently used number microfluidic application insufficient. By combining siRNA/miRNA with devices, genetic could be revealed. Microfluidic chips should clinically personal therapy point-of-care applications. At least microneedles, it ensured patients can go through treatment process more painlessly. This way, switched curable type list, targeted fewer side effects.

Язык: Английский

Процитировано

28