Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Апрель 30, 2024
The
field
of
hybrid
engineered
living
materials
seeks
to
pair
organisms
with
synthetic
generate
biocomposite
augmented
function
since
systems
can
provide
highly-programmable
and
complex
behavior.
Engineered
have
typically
been
fabricated
using
techniques
in
benign
aqueous
environments,
limiting
their
application.
In
this
work,
fabrication
is
demonstrated
which
spores
from
polymer-degrading
bacteria
are
incorporated
into
a
thermoplastic
polyurethane
high-temperature
melt
extrusion.
Bacteria
adaptive
laboratory
evolution
improve
heat
tolerance
ensure
nearly
complete
cell
survivability
during
manufacturing
at
135
°C.
Furthermore,
the
overall
tensile
properties
spore-filled
polyurethanes
substantially
improved,
resulting
significant
improvement
toughness.
biocomposites
facilitate
disintegration
compost
absence
microbe-rich
environment.
Finally,
embedded
demonstrate
rationally
programmed
function,
expressing
green
fluorescent
protein.
This
research
provides
scalable
method
fabricate
advanced
industrially-compatible
processes.
Advanced Materials,
Год журнала:
2022,
Номер
35(5)
Опубликована: Ноя. 25, 2022
Although
growth
factor
(GF)-loaded
hydrogels
have
been
explored
as
promising
materials
in
repairing
bone
defects,
it
still
remains
challenging
to
construct
smart
with
excellent
gelation/mechanical
properties
well
controllable
GF
releasing
capability.
Herein,
the
incorporation
of
morphogenetic
protein
2
(BMP-2)-functionalized
MgFe-layered
double
hydroxide
(LDH)
nanosheets
into
chitosan/silk
fibroin
(CS)
loaded
platelet-derived
factor-BB
(PDGF-BB)
a
injectable
thermo-responsive
hydrogel
(denoted
CSP-LB),
which
can
achieve
burst
release
PDGF-BB
and
sustained
BMP-2,
for
highly
efficient
regeneration
is
reported.
The
MgFe-LDH
CS
not
only
shortens
gelation
time
decreases
sol-gel
transition
temperature,
but
also
enhances
mechanical
property
hydrogel.
Because
sequential
dual-GFs
bioactive
Mg2+
/Fe3+
ions,
vitro
experiments
prove
that
CSP-LB
exhibits
angiogenic
osteogenic
compared
In
vivo
further
significantly
enhance
higher
volume
mineral
density
than
This
thermo-sensitive
possesses
capability
properties,
thus
providing
minimally
invasive
solution
defect
treatment.
ACS Nano,
Год журнала:
2023,
Номер
17(16), С. 16160 - 16173
Опубликована: Июль 31, 2023
There
is
huge
demand
for
recreating
human
skin
with
the
functions
of
epidermis
and
dermis
interactions
physical
world.
Herein,
a
biomimetic,
ultrasensitive,
multifunctional
hydrogel-based
electronic
(BHES)
was
proposed.
Its
function
mimicked
using
poly(ethylene
terephthalate)
nanoscale
wrinkles,
enabling
accurate
identification
materials
through
capabilities
to
gain/lose
electrons
during
contact
electrification.
Internal
mechanoreceptor
by
interdigital
silver
electrodes
stick–slip
sensing
identify
textures/roughness.
The
patterned
microcone
hydrogel,
achieving
pressure
sensors
high
sensitivity
(17.32
mV/Pa),
large
range
(20–5000
Pa),
low
detection
limit,
fast
response
(10
ms)/recovery
time
(17
ms).
Assisted
deep
learning,
this
BHES
achieved
accuracy
minimized
interference
in
identifying
(95.00%
10
materials)
textures
(97.20%
four
roughness
cases).
By
integrating
signal
acquisition/processing
circuits,
wearable
drone
control
system
demonstrated
three-degree-of-freedom
movement
enormous
potentials
soft
robots,
self-powered
human–machine
interaction
interfaces
digital
twins.
Chemical Reviews,
Год журнала:
2022,
Номер
123(5), С. 2349 - 2419
Опубликована: Дек. 13, 2022
Recent
advances
in
synthetic
biology
and
materials
science
have
given
rise
to
a
new
form
of
materials,
namely
engineered
living
(ELMs),
which
are
composed
matter
or
cell
communities
embedded
self-regenerating
matrices
their
own
artificial
scaffolds.
Like
natural
such
as
bone,
wood,
skin,
ELMs,
possess
the
functional
capabilities
organisms,
can
grow,
self-organize,
self-repair
when
needed.
They
also
spontaneously
perform
programmed
biological
functions
upon
sensing
external
cues.
Currently,
ELMs
show
promise
for
green
energy
production,
bioremediation,
disease
treatment,
fabricating
advanced
smart
materials.
This
review
first
introduces
dynamic
features
systems
potential
developing
novel
We
then
summarize
recent
research
progress
on
emerging
design
strategies
from
both
perspectives.
Finally,
we
discuss
positive
impacts
promoting
sustainability
key
future
directions.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Фев. 3, 2024
Abstract
Chronic
diabetic
wounds
are
at
lifelong
risk
of
developing
foot
ulcers
owing
to
severe
hypoxia,
excessive
reactive
oxygen
species
(ROS),
a
complex
inflammatory
microenvironment,
and
the
potential
for
bacterial
infection.
Here
we
develop
programmed
treatment
strategy
employing
live
Haematococcus
(HEA).
By
modulating
light
intensity,
HEA
can
be
perform
variety
functions,
such
as
antibacterial
activity,
supply,
ROS
scavenging,
immune
regulation,
suggesting
its
use
in
therapy.
Under
high
intensity
(658
nm,
0.5
W/cm
2
),
green
(GHEA)
with
efficient
photothermal
conversion
mediate
wound
surface
disinfection.
decreasing
0.1
photosynthetic
system
GHEA
continuously
produce
oxygen,
effectively
resolving
problems
hypoxia
promoting
vascular
regeneration.
Continuous
irradiation
induces
astaxanthin
(AST)
accumulation
cells,
resulting
gradual
transformation
from
red
hue
(RHEA).
RHEA
scavenges
excess
ROS,
enhances
expression
intracellular
antioxidant
enzymes,
directs
polarization
M2
macrophages
by
secreting
AST
vesicles
via
exosomes.
The
living
hydrogel
sterilize
enhance
cell
proliferation
migration
promote
neoangiogenesis,
which
could
improve
infected
healing
female
mice.
ACS Materials Letters,
Год журнала:
2023,
Номер
5(7), С. 1787 - 1830
Опубликована: Май 26, 2023
Due
to
the
good
reliability
and
long-term
stability,
self-healing
hydrogels
have
emerged
as
promising
soft
materials
for
tissue
engineering,
smart
wearable
sensors,
bioelectronics,
energy
storage
devices.
The
mechanism
depends
on
reversible
chemical
or
physical
cross-linking
interactions.
Self-healing
with
fascinating
features
(including
mechanical
performances,
biocompatibility,
conductivity,
antibacterial
ability,
responsiveness,
etc.)
are
being
designed
developed
according
practical
application
requirements.
In
this
review,
recent
progress
in
their
synthesis
strategies
multiple
applications
is
summarized.
Their
involve
processes
a
combination
of
two.
include
flexible
strain
supercapacitors,
actuators,
adhesives,
wound
healing,
drug
delivery,
tumor
treatment,
3D
printing,
etc.
Finally,
current
challenges,
future
development,
opportunities
discussed.
Nano-Micro Letters,
Год журнала:
2023,
Номер
15(1)
Опубликована: Май 28, 2023
Hydrogels
offer
tissue-like
softness,
stretchability,
fracture
toughness,
ionic
conductivity,
and
compatibility
with
biological
tissues,
which
make
them
promising
candidates
for
fabricating
flexible
bioelectronics.
A
soft
hydrogel
film
offers
an
ideal
interface
to
directly
bridge
thin-film
electronics
the
tissues.
However,
it
remains
difficult
fabricate
a
ultrathin
configuration
excellent
mechanical
strength.
Here
we
report
tissue-inspired
ultrasoft
microfiber
composite
(<
5
μm)
film,
is
currently
thinnest
as
far
know.
The
embedded
microfibers
endow
prominent
strength
(tensile
stress
~
6
MPa)
anti-tearing
property.
Moreover,
our
capability
of
tunable
properties
in
broad
range,
allowing
matching
modulus
most
tissues
organs.
incorporation
glycerol
salt
ions
imparts
high
conductivity
anti-dehydration
behavior.
Such
hydrogels
are
constructing
attaching-type
bioelectronics
monitor
biosignals.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Янв. 19, 2023
Abstract
Living
materials
bring
together
material
science
and
biology
to
allow
the
engineering
augmenting
of
living
systems
with
novel
functionalities.
Bioprinting
promises
accurate
control
over
formation
such
complex
through
programmable
deposition
cells
in
soft
materials,
but
current
approaches
had
limited
success
fine-tuning
cell
microenvironments
while
generating
robust
macroscopic
morphologies.
Here,
we
address
this
challenge
use
core-shell
microgel
ink
decouple
from
structural
shell
for
further
processing.
Cells
are
microfluidically
immobilized
viscous
core
that
can
promote
both
microbial
populations
mammalian
cellular
spheroids,
followed
by
interparticle
annealing
give
covalently
stabilized
functional
scaffolds
controlled
microporosity.
The
results
show
strategy
mitigates
leakage
affording
a
favorable
environment
culture.
Furthermore,
demonstrate
different
consortia
be
printed
into
range
applications.
By
compartmentalizing
separate
microgels,
collective
bioprocessing
capability
scaffold
is
significantly
enhanced,
shedding
light
on
strategies
augment
capabilities.
Science,
Год журнала:
2024,
Номер
384(6699), С. 1023 - 1030
Опубликована: Май 30, 2024
Seamless
interfaces
between
electronic
devices
and
biological
tissues
stand
to
revolutionize
disease
diagnosis
treatment.
However,
biomechanical
disparities
synthetic
materials
living
present
challenges
at
bioelectrical
signal
transduction
interfaces.
We
introduce
the
active
biointegrated
electronics
(ABLE)
platform,
encompassing
capabilities
across
biogenic,
biomechanical,
properties
simultaneously.
The
biointerface,
comprising
a
bioelectronics
layout
