A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(5)

Published: Nov. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Language: Английский

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High-strength hydrogels: Fabrication, reinforcement mechanisms, and applications

Nano Research, Journal Year: 2023, Volume and Issue: 16(2), P. 3475 - 3515

Published: Jan. 3, 2023

Language: Английский

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Deep-Learning Enabled Active Biomimetic Multifunctional Hydrogel Electronic Skin

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 16160 - 16173

Published: July 31, 2023

There is huge demand for recreating human skin with the functions of epidermis and dermis interactions physical world. Herein, a biomimetic, ultrasensitive, multifunctional hydrogel-based electronic (BHES) was proposed. Its function mimicked using poly(ethylene terephthalate) nanoscale wrinkles, enabling accurate identification materials through capabilities to gain/lose electrons during contact electrification. Internal mechanoreceptor by interdigital silver electrodes stick–slip sensing identify textures/roughness. The patterned microcone hydrogel, achieving pressure sensors high sensitivity (17.32 mV/Pa), large range (20–5000 Pa), low detection limit, fast response (10 ms)/recovery time (17 ms). Assisted deep learning, this BHES achieved accuracy minimized interference in identifying (95.00% 10 materials) textures (97.20% four roughness cases). By integrating signal acquisition/processing circuits, wearable drone control system demonstrated three-degree-of-freedom movement enormous potentials soft robots, self-powered human–machine interaction interfaces digital twins.

Language: Английский

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Engineered Living Materials For Sustainability

Chemical Reviews, Journal Year: 2022, Volume and Issue: 123(5), P. 2349 - 2419

Published: Dec. 13, 2022

Recent advances in synthetic biology and materials science have given rise to a new form of materials, namely engineered living (ELMs), which are composed matter or cell communities embedded self-regenerating matrices their own artificial scaffolds. Like natural such as bone, wood, skin, ELMs, possess the functional capabilities organisms, can grow, self-organize, self-repair when needed. They also spontaneously perform programmed biological functions upon sensing external cues. Currently, ELMs show promise for green energy production, bioremediation, disease treatment, fabricating advanced smart materials. This review first introduces dynamic features systems potential developing novel We then summarize recent research progress on emerging design strategies from both perspectives. Finally, we discuss positive impacts promoting sustainability key future directions.

Language: Английский

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Programmed microalgae-gel promotes chronic wound healing in diabetes

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 3, 2024

Abstract Chronic diabetic wounds are at lifelong risk of developing foot ulcers owing to severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory microenvironment, and the potential for bacterial infection. Here we develop programmed treatment strategy employing live Haematococcus (HEA). By modulating light intensity, HEA can be perform variety functions, such as antibacterial activity, supply, ROS scavenging, immune regulation, suggesting its use in therapy. Under high intensity (658 nm, 0.5 W/cm 2 ), green (GHEA) with efficient photothermal conversion mediate wound surface disinfection. decreasing 0.1 photosynthetic system GHEA continuously produce oxygen, effectively resolving problems hypoxia promoting vascular regeneration. Continuous irradiation induces astaxanthin (AST) accumulation cells, resulting gradual transformation from red hue (RHEA). RHEA scavenges excess ROS, enhances expression intracellular antioxidant enzymes, directs polarization M2 macrophages by secreting AST vesicles via exosomes. The living hydrogel sterilize enhance cell proliferation migration promote neoangiogenesis, which could improve infected healing female mice.

Language: Английский

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Self-Healing Hydrogels: From Synthesis to Multiple Applications

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(7), P. 1787 - 1830

Published: May 26, 2023

Due to the good reliability and long-term stability, self-healing hydrogels have emerged as promising soft materials for tissue engineering, smart wearable sensors, bioelectronics, energy storage devices. The mechanism depends on reversible chemical or physical cross-linking interactions. Self-healing with fascinating features (including mechanical performances, biocompatibility, conductivity, antibacterial ability, responsiveness, etc.) are being designed developed according practical application requirements. In this review, recent progress in their synthesis strategies multiple applications is summarized. Their involve processes a combination of two. include flexible strain supercapacitors, actuators, adhesives, wound healing, drug delivery, tumor treatment, 3D printing, etc. Finally, current challenges, future development, opportunities discussed.

Language: Английский

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Biological Tissue-Inspired Ultrasoft, Ultrathin, and Mechanically Enhanced Microfiber Composite Hydrogel for Flexible Bioelectronics

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: May 28, 2023

Hydrogels offer tissue-like softness, stretchability, fracture toughness, ionic conductivity, and compatibility with biological tissues, which make them promising candidates for fabricating flexible bioelectronics. A soft hydrogel film offers an ideal interface to directly bridge thin-film electronics the tissues. However, it remains difficult fabricate a ultrathin configuration excellent mechanical strength. Here we report tissue-inspired ultrasoft microfiber composite (< 5 μm) film, is currently thinnest as far know. The embedded microfibers endow prominent strength (tensile stress ~ 6 MPa) anti-tearing property. Moreover, our capability of tunable properties in broad range, allowing matching modulus most tissues organs. incorporation glycerol salt ions imparts high conductivity anti-dehydration behavior. Such hydrogels are constructing attaching-type bioelectronics monitor biosignals.

Language: Английский

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Active biointegrated living electronics for managing inflammation

Science, Journal Year: 2024, Volume and Issue: 384(6699), P. 1023 - 1030

Published: May 30, 2024

Seamless interfaces between electronic devices and biological tissues stand to revolutionize disease diagnosis treatment. However, biomechanical disparities synthetic materials living present challenges at bioelectrical signal transduction interfaces. We introduce the active biointegrated electronics (ABLE) platform, encompassing capabilities across biogenic, biomechanical, properties simultaneously. The biointerface, comprising a bioelectronics layout

Language: Английский

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Self-healing hydrogels as injectable implants: Advances in translational wound healing

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215790 - 215790

Published: March 20, 2024

Language: Английский

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A strategy for tough and fatigue-resistant hydrogels via loose cross-linking and dense dehydration-induced entanglements

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 13, 2024

Abstract Outstanding overall mechanical properties are essential for the successful utilization of hydrogels in advanced applications such as human-machine interfaces and soft robotics. However, conventional suffer from fracture toughness-stiffness conflict fatigue threshold-stiffness conflict, limiting their applicability. Simultaneously enhancing toughness, threshold, stiffness hydrogels, especially within a homogeneous single network structure, has proven to be formidable challenge. In this work, we overcome challenge through design loosely cross-linked hydrogel with slight dehydration. Experimental results reveal that slightly-dehydrated, polyacrylamide hydrogel, an original/current water content 87%/70%, exhibits improved properties, which is primarily attributed synergy between long-chain structure dense dehydration-induced entanglements. Importantly, creation these microstructures does not require intricate or processing. This simple approach holds significant potential where excellent anti-fracture fatigue-resistant necessary.

Language: Английский

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