Chemosensors,
Год журнала:
2023,
Номер
11(8), С. 433 - 433
Опубликована: Авг. 4, 2023
The
pathological
process
involves
a
range
of
intrinsic
biochemical
markers.
detection
multiple
biological
parameters
is
imperative
for
providing
precise
diagnostic
information
on
diseases.
In
vivo
multichannel
fluorescence
biosensing
facilitates
the
acquisition
at
different
levels,
such
as
tissue,
cellular,
and
molecular,
with
rapid
feedback,
high
sensitivity,
spatiotemporal
resolution.
Notably,
imaging
in
near-infrared-II
(NIR-II)
window
(950–1700
nm)
promises
deeper
optical
penetration
depth
diminished
interferential
autofluorescence
compared
visible
(400–700
near-infrared-I
(NIR-I,
700–950
regions,
making
it
promising
option
toward
clinical
practice.
Furthermore,
use
advanced
NIR-II
fluorophores
supports
development
spectra-domain,
lifetime-domain,
fluorescence-lifetime
modes.
This
review
summarizes
versatile
designs
functions
various
scenarios,
including
monitoring,
cellular
tracking,
analysis.
Additionally,
briefly
discusses
desirable
traits
required
translation
safety,
long-wavelength
emission,
clear
components.
Chemical Reviews,
Год журнала:
2023,
Номер
124(2), С. 554 - 628
Опубликована: Ноя. 22, 2023
In
vivo
imaging
technologies
have
emerged
as
a
powerful
tool
for
both
fundamental
research
and
clinical
practice.
particular,
luminescence
in
the
tissue-transparent
near-infrared
(NIR,
700–1700
nm)
region
offers
tremendous
potential
visualizing
biological
architectures
pathophysiological
events
living
subjects
with
deep
tissue
penetration
high
contrast
owing
to
reduced
light–tissue
interactions
of
absorption,
scattering,
autofluorescence.
The
distinctive
quantum
effects
nanocrystals
been
harnessed
achieve
exceptional
photophysical
properties,
establishing
them
promising
category
luminescent
probes.
this
comprehensive
review,
between
light
tissues,
well
advantages
NIR
imaging,
are
initially
elaborated.
Subsequently,
we
focus
on
achieving
improved
by
optimizing
performance
nanocrystal
fluorophores.
ingenious
design
strategies
probes
discussed,
along
their
respective
biomedical
applications
versatile
modalities.
Finally,
thought-provoking
reflections
challenges
prospects
future
translation
nanocrystal-based
wisely
provided.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(18), С. 6447 - 6496
Опубликована: Янв. 1, 2023
This
review
highlights
the
use
of
nanoprobes
to
stratify
various
therapeutic
modalities
and
provides
an
outlook
on
challenges
future
directions
for
patient
stratification.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(12), С. 6399 - 6444
Опубликована: Янв. 1, 2024
This
review
highlights
recent
advances
in
immunological
nanomaterials
against
metastasis
and
summarizes
various
nanomaterial-mediated
immunotherapy
strategies.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(26)
Опубликована: Авг. 4, 2023
Abstract
The
application
of
nanomaterials
in
healthcare
has
emerged
as
a
promising
strategy
due
to
their
unique
structural
diversity,
surface
properties,
and
compositional
diversity.
In
particular,
have
found
significant
role
improving
drug
delivery
inhibiting
the
growth
metastasis
tumor
cells.
Moreover,
recent
studies
highlighted
potential
modulating
microenvironment
(TME)
enhancing
activity
immune
cells
improve
therapy
efficacy.
Various
types
are
currently
utilized
carriers,
immunosuppressants,
activators,
immunoassay
reagents,
more
for
immunotherapy.
Necessarily,
used
immunotherapy
can
be
grouped
into
two
categories:
organic
inorganic
nanomaterials.
Though
both
shown
ability
achieve
purpose
immunotherapy,
composition
properties
result
differences
mechanisms
modes
action.
Organic
further
divided
polymers,
cell
membranes,
nanoemulsion‐modified,
hydrogel
forms.
At
same
time,
broadly
classified
nonmetallic
metallic
current
work
aims
explore
action
these
different
prospects
promoting
