Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(46), P. 31873 - 31884
Published: Nov. 6, 2024
Simultaneous detection of different biomarkers related to the spatiotemporally dynamic immune events is particular importance for accurate evaluation antitumor effects. Here, we have developed an AND-gate logic dual resonance energy transfer nanoprobe (named DRET) monitoring programmed CD8
Language: Английский
Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628
Published: Nov. 22, 2023
In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.
Language: Английский
Citations
73
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(21), P. 4600 - 4618
Published: Jan. 1, 2023
Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive therapeutic method for cancer treatment.
Language: Английский
Citations
62
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496
Published: Jan. 1, 2023
This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.
Language: Английский
Citations
51
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 365, P. 1058 - 1073
Published: Jan. 1, 2024
Language: Английский
Citations
29
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444
Published: Jan. 1, 2024
This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.
Language: Английский
Citations
24
Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(21)
Published: Sept. 1, 2022
Abstract Cancer immunotherapy is restricted to immune resistance caused by immunosuppressive tumor microenvironment. Pyroptosis involved in antitumor as a new schedule prospective reverse immunosuppression. Herein, acidic microenvironment (TME)‐evoked MRC nanoparticles (MRC NPs) co‐delivering agonist RGX‐104 and photosensitizer chlorine e6 (Ce6) are reported for pyroptosis‐mediated immunotherapy. remodels TME transcriptional activation of ApoE regress myeloid‐derived suppressor cells' (MDSCs) activity, which neatly creates foreshadowing intensifying pyroptosis. Considering Ce6‐triggered photodynamic therapy (PDT) can strengthen oxidative stress organelles destruction increase immunogenicity, immunomodulatory‐photodynamic nanodrugs will implement an aforementioned two‐pronged strategy enhance gasdermin E (GSDME)‐dependent RNA‐seq analysis at the cellular level introduced first elucidate intimate relationship between acting on LXR/ApoE axis pyroptosis, where provides prerequisite pyroptosis participating therapy. Briefly, with favorable biocompatibility tackles obstacle hydrophobic drugs delivery, becomes powerful inducer reinforce efficacy. MRC‐elicited combination anti‐PD‐1 blockade boosts response solid tumors, successfully arresting invasive metastasis extending survival based remarkable immunity. may initiate window immuno‐photo stimulators augmenting pyroptosis‐based
Language: Английский
Citations
40
Nano Today, Journal Year: 2022, Volume and Issue: 48, P. 101727 - 101727
Published: Dec. 17, 2022
Language: Английский
Citations
39
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(26)
Published: Aug. 4, 2023
Abstract The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, have found significant role improving drug delivery inhibiting the growth metastasis tumor cells. Moreover, recent studies highlighted potential modulating microenvironment (TME) enhancing activity immune cells improve therapy efficacy. Various types are currently utilized carriers, immunosuppressants, activators, immunoassay reagents, more for immunotherapy. Necessarily, used immunotherapy can be grouped into two categories: organic inorganic nanomaterials. Though both shown ability achieve purpose immunotherapy, composition properties result differences mechanisms modes action. Organic further divided polymers, cell membranes, nanoemulsion‐modified, hydrogel forms. At same time, broadly classified nonmetallic metallic current work aims explore action these different prospects promoting
Language: Английский
Citations
36
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 463, P. 142495 - 142495
Published: March 20, 2023
Language: Английский
Citations
35
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 465, P. 142961 - 142961
Published: April 13, 2023
Language: Английский
Citations
32