Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 1115 - 1129
Published: Nov. 9, 2024
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)
Published: Sept. 19, 2023
Abstract Insufficient activation of the stimulator interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits effect cancer immunotherapy. Herein, tumor (TME)‐responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING Toll‐like receptor 4 (TLR4) to augment via TLR4‐mediated nuclear factor‐kappa B stimulation, leading increased secretion type I interferons (i.e., 4.0‐fold enhancement IFN‐β) pro‐inflammatory cytokines promote a specific T cell immune response. Moreover, PMM NPs relieve immunosuppression TME by decreasing percentage regulatory cells, polarizing M2 macrophages M1 type, thus creating an immune‐supportive unleash cascade adaptive Combined with anti‐PD‐1 antibody, synergistic efficacy is achieved in both inflamed colorectal noninflamed metastatic breast models. rechallenging tumor‐free animals homotypic cells induced complete rejection, indicating generation systemic antitumor memory. These TME‐responsive may open new avenue achieve spatiotemporal orchestration activation, providing promising clinical candidate for next‐generation
Language: Английский
Citations
68
Exploration, Journal Year: 2024, Volume and Issue: 4(6)
Published: March 22, 2024
Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.
Language: Английский
Citations
31
Science Advances, Journal Year: 2024, Volume and Issue: 10(26)
Published: June 28, 2024
Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H
Language: Английский
Citations
28
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)
Published: March 19, 2024
Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.
Language: Английский
Citations
27
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444
Published: Jan. 1, 2024
This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.
Language: Английский
Citations
26
Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(4), P. 1768 - 1799
Published: Feb. 7, 2024
Adjuvants are of critical value in vaccine development as they act on enhancing immunogenicity antigen and inducing long-lasting immunity. However, there only a few adjuvants that have been approved for clinical use, which highlights the need exploring developing new to meet growing demand vaccination. Recently, emerging evidence demonstrates cGAS-STING pathway orchestrates innate adaptive immunity by generating type I interferon responses. Many agonists developed tested preclinical research treatment cancer or infectious diseases with promising results. As adjuvants, demonstrated their potential activate robust defense various diseases, including COVID-19 infection. This review summarized current developments field special focus latest applications Potential challenges were also discussed hope sparking future interests further adjuvants.
Language: Английский
Citations
19
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125285 - 125285
Published: Jan. 1, 2025
Language: Английский
Citations
5
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.
Language: Английский
Citations
3
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 15, 2025
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.
Language: Английский
Citations
3
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Nov. 16, 2022
Abstract With the economy's globalization and population's aging, cancer has become leading cause of death in most countries. While imposing a considerable burden on society, high morbidity mortality rates have continuously prompted researchers to develop new oncology treatment options. Anti-tumor regimens evolved from early single surgical combined (or not) chemoradiotherapy then current stage tumor immunotherapy. Tumor immunotherapy undoubtedly pulled some patients back death. However, this strategy activating or boosting body's immune system hardly benefits patients. It is limited by low bioavailability, response rate severe side effects. Thankfully, rapid development nanotechnology broken through bottleneck problem anti-tumor Multifunctional nanomaterials can not only kill tumors combining drugs but also be designed enhance immunity thus achieve multi-treatment effect. worth noting that variety nanomaterials, their modifiability, diversity combinations allow them shine antitumor In paper, several nanobiotics commonly used at are discussed, they activate with unique advantages. conclusion, we reviewed recent advances based such as biological cell membrane modification, self-assembly, mesoporous, metal hydrogels, explore directions strategies for
Language: Английский
Citations
46