Resources Chemicals and Materials,
Год журнала:
2024,
Номер
3(2), С. 103 - 122
Опубликована: Янв. 15, 2024
4,4-Difluoro-4-bora-3a,4a-diaza-sindacene
(BODIPY)
is
a
sort
of
photofunctional
dye
which
possesses
advantages
including
strong
light-capturing
property,
high
photon-resistance,
etc.
Meso-N
substituted
aza-BODIPY
crucial
derivative
BODIPY
scaffold
that
has
the
favorable
optical
properties
and
significant
spectral
redshift.
The
photophysical
can
be
tuned
by
molecular
design,
attenuation
path
excited
state
energy
release
absorbed
light
well
controlled
via
structural
modifications,
enabling
tailored
application.
It
been
extensively
employed
in
life
medicine
fields
fluorescence
imaging
diagnosis,
photodynamic
therapy
photosensitizer
photothermal
reagent
so
forth.
Extensive
research
review
have
performed
these
areas.
However,
BODIPYs/aza-BODIPYs
role
energy,
catalysis,
optoelectronics,
photo-responsive
materials
other
fields.
Nevertheless,
there
are
relatively
few
studies
reviews
on
modification
application
based
BODIPY/aza-BODIPY
scaffold.
Herein,
this
we
summarized
aforementioned
fields,
with
regulation
as
foundation
utilization
above
objective,
intention
providing
inspiration
for
exploration
innovative
field
resource
conversion
functional
materials.
Advanced Materials,
Год журнала:
2024,
Номер
36(28)
Опубликована: Апрель 30, 2024
Abstract
Fluorescence
imaging‐guided
photodynamic
therapy
(FIG‐PDT)
holds
promise
for
cancer
treatment,
yet
challenges
persist
in
poor
imaging
quality,
phototoxicity,
and
insufficient
anti‐tumor
effect.
Herein,
a
novel
nanoplatform,
LipoHPM,
designed
to
address
these
challenges,
is
reported.
This
approach
employs
an
acid‐sensitive
amine
linker
connect
biotin‐modified
hydrophilic
polymer
(
Biotin
PEG)
with
new
hydrophobic
photosensitizer
(MBA),
forming
OFF‐state
P
EG‐
M
BA
(PM)
micelles
via
aggregation‐caused
quenching
(ACQ)
These
are
then
co‐loaded
the
tumor
penetration
enhancer
hydralazine
H
DZ)
into
pH‐sensitive
liposomes
(Lipo
HPM
).
Leveraging
ACQ
effect,
LipoHPM
silent
both
fluorescence
reactive
oxygen
species
(ROS)
generation
during
blood
circulation
but
restores
properties
upon
disassembly.
Following
intravenous
injection
tumor‐bearing
mice,
actively
targets
cells
overexpressing
biotin‐receptors,
contributing
enhanced
accumulation.
Upon
cellular
internalization,
disassembles
within
lysosomes,
releasing
HDZ
enhance
inhibit
metastasis.
Concurrently,
activate
boost
production
of
type‐I
type‐II
ROS
eradication.
Therefore,
smart
synergistically
integrates
near‐infrared
emission,
activatable
imaging,
robust
generation,
efficient
anti‐metastasis
activity,
successfully
overcoming
limitations
conventional
photosensitizers
establishing
itself
as
promising
nanoplatform
potent
FIG‐PDT
applications.
Abstract
Phototherapeutic
nanoplatforms
that
combine
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
with
the
guidance
of
photoacoustic
(PA)
imaging
are
an
effective
strategy
for
treatment
tumors,
but
establishing
a
universal
method
this
has
been
challenging.
In
study,
we
present
supramolecular
assembly
based
on
Förster
resonance
energy
transfer
to
construct
nanostructured
phototherapeutic
agent
(PcDA)
via
anion
cation
interaction
between
two
water‐soluble
phthalocyanine
ramifications,
PcD
PcA.
This
approach
promotes
absorption
energy,
thus
enhancing
generation
reactive
oxygen
species
(ROS)
heat
by
PcDA,
improving
its
therapeutic
efficacy,
overcoming
low
photon
utilization
efficiency
conventional
PSs.
Notably,
after
intravenous
injection
neoplastic
sites
could
be
clearly
visualized
using
PA
imaging,
signal‐to‐liver
ratio
as
high
11.9.
Due
these
unique
features,
PcDA
exhibits
excellent
antitumor
efficacy
in
preclinical
model
at
dose
light
irradiation.
study
offers
general
development
efficient
agents
simultaneous
effect
PDT
PTT
against
tumors
assistance
imaging.
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 24, 2025
Abstract
Sonodynamic
therapy
(SDT)
as
an
emerging
modality
for
malignant
tumors
mainly
involves
in
sonosensitizers
and
low-intensity
ultrasound
(US),
which
can
safely
penetrate
the
tissue
without
significant
attenuation.
SDT
not
only
has
advantages
including
high
precision,
non-invasiveness,
minimal
side
effects,
but
also
overcomes
limitation
of
low
penetration
light
to
deep
tumors.
The
cytotoxic
reactive
oxygen
species
be
produced
by
utilization
combined
with
US
kill
tumor
cells.
However,
underlying
mechanism
been
elucidated,
its
unsatisfactory
efficiency
retards
further
clinical
application.
Herein,
we
shed
on
main
mechanisms
types
sonosensitizers,
organic
inorganic
sonosensitizers.
Due
development
nanotechnology,
many
novel
nanoplatforms
are
utilized
this
arisen
field
solve
barriers
enable
continuous
innovation.
This
review
highlights
potential
nanosonosensitizers
focus
enhanced
based
monotherapy
or
synergistic
that
difficult
reach
traditional
treatment,
especially
orthotopic
cancers.
Russian Chemical Reviews,
Год журнала:
2023,
Номер
92(12), С. RCR5104 - RCR5104
Опубликована: Дек. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(25), С. 9646 - 9653
Опубликована: Июнь 13, 2023
Fluorescent
rotors
with
aggregation-induced
emission
(AIE)
and
organelle-targeting
properties
have
attracted
great
attention
for
sensing
subcellular
viscosity
changes,
which
could
help
understand
the
relationships
of
abnormal
fluctuations
many
associated
diseases.
Despite
numerous
efforts
spent,
it
remains
rare
urgent
to
explore
dual-organelle
targeting
probes
their
structural
viscosity-responsive
AIE
properties.
Therefore,
in
this
work,
we
reported
four
meso-five-membered
heterocycle-substituted
BODIPY-based
fluorescent
probes,
explored
properties,
further
investigated
localization
viscosity-sensing
applications
living
cells.
Interestingly,
meso-thiazole
probe
1
showed
both
good
(in
pure
water)
successfully
target
mitochondria
lysosomes,
imaging
cellular
changes
by
treating
lipopolysaccharide
nystatin,
attributing
free
rotation
potential
ability
group.
The
meso-benzothiophene
3
a
saturated
sulfur
only
cells
aggregation-caused
quenching
effect
no
localization.
meso-imidazole
2
phenomenon
without
an
obvious
property
C═N
bond,
while
meso-benzopyrrole
4
displayed
fluorescence
polar
solvents.
first
time,
structure-property
among
these,
bond
on
meso-thiazole,
potentially
contributing
corresponding
served
as
sensitive
rotor
lysosomes.
Nano Materials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Two-dimensional
(2D)
materials
have
attracted
considerable
research
interest
due
to
their
precisely
defined
properties
and
versatile
applications.
In
this
realm,
borophene
-
a
single
atomic
sheet
of
boron
atoms
arranged
in
honeycomb
lattice
has
emerged
as
promising
candidate.
While
borophenes
were
theoretically
predicted
unique
structural,
optical,
electronic
properties,
the
experimental
synthesis
crystalline
sheets
was
first
demonstrated
on
metal
substrates
2015,
marking
crucial
milestone.
Since
then,
efforts
focused
controlling
semiconducting
polymorphs
exploring
novel
physical
characteristics.
This
review
aims
explore
potential
2D
materials,
specifically
borophene,
various
technological
fields
such
batteries,
supercapacitors,
fuel
cells,
more.
The
analysis
emphasises
meticulous
scrutiny
techniques
fundamental
importance
realising
borophene's
properties.
Specifically,
high
carrier
mobilities,
tuneable
bandgaps,
exceptional
thermal
conductivity
are
highlighted.
By
providing
comprehensive
outlook
significance
advancing
science
technologies,
contributes
shaping
landscape
material
research.
Advanced Materials,
Год журнала:
2024,
Номер
36(48)
Опубликована: Окт. 6, 2024
Rheumatoid
arthritis
(RA)
represents
an
insidious
autoimmune
inflammatory
disorder
that
severely
lowers
the
life
quality
by
progressively
destructing
joint
functions
and
eventually
causing
permanent
disability,
posing
a
serious
public
health
problem.
Here,
advanced
theranostic
probe
is
introduced
integrates
activatable
second
near-infrared
(NIR-II)
fluorescence
imaging
for
precise
RA
diagnosis
with
multi-pronged
treatments.
A
novel
molecular
comprising
long-wavelength
aggregation-induced
emission
unit
manganese
carbonyl
cage
motif
synthesized,
which
enables
NIR-II
activation
concurrently
releasing
therapeutic
carbon
monoxide
(CO)
gas
in
inflamed
microenvironment.
This
self-assembles
into
biocompatible
nanoprobe,
subsequently
conjugated
anti-IL-6R
antibody
to
afford
active-targeting
ability
of
RA.
The
nanoprobe
exhibits
significant
turn-on
signal
at
lesion,
enabling
highly
sensitive
real-time
monitoring.
combination
ROS
scavenging,
on-demand
CO
release,
IL-6
signaling
blockade
results
potent
effect
synergistic
immunomodulation
impact,
significantly
alleviating
symptoms
preventing
destruction.
research
introduces
paradigm
development
high-performance,
strategies
facilitate
detection
enhanced
treatment
RA-related
diseases.
