Rational design of photofunctional dyes BODIPYs/aza-BODIPYs and applications for photocatalysis, photoelectric conversion and thermochromic materials DOI Creative Commons

Dongxiang Zhang,

Linxuan Liu, Xin Zhang

et al.

Resources Chemicals and Materials, Journal Year: 2024, Volume and Issue: 3(2), P. 103 - 122

Published: Jan. 15, 2024

4,4-Difluoro-4-bora-3a,4a-diaza-sindacene (BODIPY) is a sort of photofunctional dye which possesses advantages including strong light-capturing property, high photon-resistance, etc. Meso-N substituted aza-BODIPY crucial derivative BODIPY scaffold that has the favorable optical properties and significant spectral redshift. The photophysical can be tuned by molecular design, attenuation path excited state energy release absorbed light well controlled via structural modifications, enabling tailored application. It been extensively employed in life medicine fields fluorescence imaging diagnosis, photodynamic therapy photosensitizer photothermal reagent so forth. Extensive research review have performed these areas. However, BODIPYs/aza-BODIPYs role energy, catalysis, optoelectronics, photo-responsive materials other fields. Nevertheless, there are relatively few studies reviews on modification application based BODIPY/aza-BODIPY scaffold. Herein, this we summarized aforementioned fields, with regulation as foundation utilization above objective, intention providing inspiration for exploration innovative field resource conversion functional materials.

Language: Английский

Smart Nanoassembly Enabling Activatable NIR Fluorescence and ROS Generation with Enhanced Tumor Penetration for Imaging‐Guided Photodynamic Therapy DOI

Siqin Chen,

Bowen Li,

Yifan Yue

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: April 30, 2024

Abstract Fluorescence imaging‐guided photodynamic therapy (FIG‐PDT) holds promise for cancer treatment, yet challenges persist in poor imaging quality, phototoxicity, and insufficient anti‐tumor effect. Herein, a novel nanoplatform, LipoHPM, designed to address these challenges, is reported. This approach employs an acid‐sensitive amine linker connect biotin‐modified hydrophilic polymer ( Biotin PEG) with new hydrophobic photosensitizer (MBA), forming OFF‐state P EG‐ M BA (PM) micelles via aggregation‐caused quenching (ACQ) These are then co‐loaded the tumor penetration enhancer hydralazine H DZ) into pH‐sensitive liposomes (Lipo HPM ). Leveraging ACQ effect, LipoHPM silent both fluorescence reactive oxygen species (ROS) generation during blood circulation but restores properties upon disassembly. Following intravenous injection tumor‐bearing mice, actively targets cells overexpressing biotin‐receptors, contributing enhanced accumulation. Upon cellular internalization, disassembles within lysosomes, releasing HDZ enhance inhibit metastasis. Concurrently, activate boost production of type‐I type‐II ROS eradication. Therefore, smart synergistically integrates near‐infrared emission, activatable imaging, robust generation, efficient anti‐metastasis activity, successfully overcoming limitations conventional photosensitizers establishing itself as promising nanoplatform potent FIG‐PDT applications.

Language: Английский

Citations

21
Supramolecular phthalocyanine assemblies‐enhanced synergistic photodynamic and photothermal therapy guided by photoacoustic imaging DOI Creative Commons
Yuanyuan Zhao, Xiaojun Zhang, Zixuan Chen

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Feb. 1, 2024

Abstract Phototherapeutic nanoplatforms that combine photodynamic therapy (PDT) and photothermal (PTT) with the guidance of photoacoustic (PA) imaging are an effective strategy for treatment tumors, but establishing a universal method this has been challenging. In study, we present supramolecular assembly based on Förster resonance energy transfer to construct nanostructured phototherapeutic agent (PcDA) via anion cation interaction between two water‐soluble phthalocyanine ramifications, PcD PcA. This approach promotes absorption energy, thus enhancing generation reactive oxygen species (ROS) heat by PcDA, improving its therapeutic efficacy, overcoming low photon utilization efficiency conventional PSs. Notably, after intravenous injection neoplastic sites could be clearly visualized using PA imaging, signal‐to‐liver ratio as high 11.9. Due these unique features, PcDA exhibits excellent antitumor efficacy in preclinical model at dose light irradiation. study offers general development efficient agents simultaneous effect PDT PTT against tumors assistance imaging.

Language: Английский

Citations

20
Recent advances in near-infrared-II organic J-aggregates for bio-applications DOI

Junchao Xu,

Xudong Zheng, Tian‐Bing Ren

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216379 - 216379

Published: Jan. 4, 2025

Language: Английский

Citations

4
Thiophene engineering of near-infrared D-π-A nano-photosensitizers for enhanced multiple phototheranostics and inhibition of tumor metastasis DOI
Xingyu Zhao,

Jiaping Shen,

Huixuan Qi

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 291 - 303

Published: Jan. 17, 2025

Language: Английский

Citations

2
Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment DOI Creative Commons
Mengyao Yang, Xin Wang,

Mengke Peng

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Language: Английский

Citations

2
The green chemistry paradigm in modern organic synthesis DOI
Sergei G. Zlotin, Ksenia S. Egorova, Valentine P. Ananikov

et al.

Russian Chemical Reviews, Journal Year: 2023, Volume and Issue: 92(12), P. RCR5104 - RCR5104

Published: Dec. 1, 2023

After the appearance of green chemistry concept, which was introduced in vocabulary early 1990s, its main statements have been continuously developed and modified. Currently, there are 10–12 cornerstones that should form basis for an ideal chemical process. This review analyzes accumulated experience achievements towards design products processes reduce or eliminate use generation hazardous substances. The presents views leading Russian scientists specializing various fields this subject, including homogeneous heterogeneous catalysis, fine basic organic synthesis, electrochemistry, polymer chemistry, based on bio-renewable feedstocks energetic compounds materials. A new approach to quantitative evaluation environmental friendliness by authors is described. <br> bibliography includes 1761.

Language: Английский

Citations

40
BODIPY-based probes for hypoxic environments DOI
Lizhi Gai, Yanfei Liu, Zhikuan Zhou

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215041 - 215041

Published: Feb. 7, 2023

Language: Английский

Citations

38
Development of meso-Five-Membered Heterocycle BODIPY-Based AIE Fluorescent Probes for Dual-Organelle Viscosity Imaging DOI
Wen‐Jing Shi,

Xuhui Yan,

Jinrong Yang

et al.

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(25), P. 9646 - 9653

Published: June 13, 2023

Fluorescent rotors with aggregation-induced emission (AIE) and organelle-targeting properties have attracted great attention for sensing subcellular viscosity changes, which could help understand the relationships of abnormal fluctuations many associated diseases. Despite numerous efforts spent, it remains rare urgent to explore dual-organelle targeting probes their structural viscosity-responsive AIE properties. Therefore, in this work, we reported four meso-five-membered heterocycle-substituted BODIPY-based fluorescent probes, explored properties, further investigated localization viscosity-sensing applications living cells. Interestingly, meso-thiazole probe 1 showed both good (in pure water) successfully target mitochondria lysosomes, imaging cellular changes by treating lipopolysaccharide nystatin, attributing free rotation potential ability group. The meso-benzothiophene 3 a saturated sulfur only cells aggregation-caused quenching effect no localization. meso-imidazole 2 phenomenon without an obvious property C═N bond, while meso-benzopyrrole 4 displayed fluorescence polar solvents. first time, structure-property among these, bond on meso-thiazole, potentially contributing corresponding served as sensitive rotor lysosomes.

Language: Английский

Citations

37
Borophene: A 2D wonder shaping the future of nanotechnology and materials science DOI Creative Commons
Raghvendra Kumar Mishra, Jayati Sarkar,

Kartikey Verma

et al.

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Two-dimensional (2D) materials have attracted considerable research interest due to their precisely defined properties and versatile applications. In this realm, borophene - a single atomic sheet of boron atoms arranged in honeycomb lattice has emerged as promising candidate. While borophenes were theoretically predicted unique structural, optical, electronic properties, the experimental synthesis crystalline sheets was first demonstrated on metal substrates 2015, marking crucial milestone. Since then, efforts focused controlling semiconducting polymorphs exploring novel physical characteristics. This review aims explore potential 2D materials, specifically borophene, various technological fields such batteries, supercapacitors, fuel cells, more. The analysis emphasises meticulous scrutiny techniques fundamental importance realising borophene's properties. Specifically, high carrier mobilities, tuneable bandgaps, exceptional thermal conductivity are highlighted. By providing comprehensive outlook significance advancing science technologies, contributes shaping landscape material research.

Language: Английский

Citations

15
Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis DOI Open Access
Yuan Zhang, Dongfang Liu, Wenwen Chen

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(48)

Published: Oct. 6, 2024

Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, posing a serious public health problem. Here, advanced theranostic probe is introduced integrates activatable second near-infrared (NIR-II) fluorescence imaging for precise RA diagnosis with multi-pronged treatments. A novel molecular comprising long-wavelength aggregation-induced emission unit manganese carbonyl cage motif synthesized, which enables NIR-II activation concurrently releasing therapeutic carbon monoxide (CO) gas in inflamed microenvironment. This self-assembles into biocompatible nanoprobe, subsequently conjugated anti-IL-6R antibody to afford active-targeting ability of RA. The nanoprobe exhibits significant turn-on signal at lesion, enabling highly sensitive real-time monitoring. combination ROS scavenging, on-demand CO release, IL-6 signaling blockade results potent effect synergistic immunomodulation impact, significantly alleviating symptoms preventing destruction. research introduces paradigm development high-performance, strategies facilitate detection enhanced treatment RA-related diseases.

Language: Английский

Citations

15