Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Язык: Английский

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Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(30), С. 16658 - 16668

Опубликована: Июль 24, 2023

Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and self-protective mechanism cells significantly weakens therapeutic efficiency. Here, a bioorthogonal nanoregulator constructed to induce disrupt checkpoint, enabling high-efficiency The allows situ synthesis accumulation photosensitizer PpIX mitochondria directly produce mitochondrial ROS, thus triggering pyroptosis. Meanwhile, generated inhibitor via palladium-catalyzed chemistry can boost efficacy. With biomimetic membrane coating, this platform for modulating presents specificity poses no harm normal tissue, resulting highly efficient safe antitumor treatment. To our knowledge, first report on disrupting intrinsic protective tumor This work highlights plays key regulative role therapy, which would motivate future design regimens.

Язык: Английский

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Recent advances in photo‐responsive carbon dots for tumor therapy

Deleted Journal, Год журнала: 2024, Номер 2(2)

Опубликована: Май 1, 2024

Abstract The precision treatment of tumors with minimal side effects is associated improved human health and quality life. In recent years, phototherapy has attracted significant attention in tumor therapy due to its versatility, spatiotemporal controllability, non‐resistance, effects. Carbon dots (CDs) are considered promising reagents because their simple preparation, facilitated surface modification, tunable energy bands, excellent electron‐transfer capabilities, remarkable photoelectric photothermal conversion properties, outstanding biocompatibility. This review summarizes advancements photo‐responsive CDs for photodynamic the emerging photocatalytic tumors. Finally, article discusses main challenges development oncology therapeutics strategies overcome these challenges.

Язык: Английский

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Dendritic Nanomedicine with Boronate Bonds for Augmented Chemo‐Immunotherapy via Synergistic Modulation of Tumor Immune Microenvironment

Advanced Materials, Год журнала: 2023, Номер 36(2)

Опубликована: Сен. 25, 2023

Unsatisfied tumor accumulation of chemotherapeutic drugs and a complicated immunosuppressive microenvironment diminish the immune response rate therapeutic effect. Surface modification these with target ligands can promote their cellular internalization, but modified may be subjected to unexpected recognition clearance. Herein, phenylboronic acid (PBA) group-shieldable dendritic nanomedicine that integrates an immunogenic cell death (ICD)-inducing agent (epirubicin, Epi) indoleamine 2,3-dioxgenase 1 (IDO1) inhibitor (NLG919) is reported for chemo-immunotherapy. This NLG919-loaded Epi-conjugated PEGylated dendrimers bridged boronate bonds (NLG919@Epi-DBP) maintains stable nanostructure during circulation. Under moderate acidic condition, PBA group exposes sialic residue on membrane enhance internalization penetration NLG919@Epi-DBP. At pH 5.0, NLG919@Epi-DBP rapidly disassembles release incorporated Epi NLG919. triggers robust ICD cells evokes strong response. In addition, inhibition IDO1 activity downregulates metabolism L-tryptophan kynurenine, leading reduction in recruitment modulation microenvironment. Collectively, this promising strategy has been demonstrated evoke as well remodel enhanced chemo-immunotherapeutic

Язык: Английский

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Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Aggregate, Год журнала: 2024, Номер 5(4)

Опубликована: Март 10, 2024

Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.

Язык: Английский

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Achieving Bright and Long‐Lived Aqueous Room‐Temperature Phosphorescence of Carbon Nitrogen Dots Through In Situ Host–Guest Binding

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Фев. 29, 2024

Abstract The development of bright and long‐lived aqueous room‐temperature phosphorescent (RTP) materials holds paramount importance in broadening the application scope RTP material system. However, conventional usually exhibit low efficiency short lifetime solution. Herein, an situ host–guest strategy is proposed to achieve cyanuric acid (CA)‐derived carbon nitrogen dots (CNDs) composite (CNDs@CA) that demonstrates a significant enhancement both quantum yield (QY) mediated by water. Detailed investigations reveal robust hydrogen bonding networks between CNDs@CA water effectively stabilize triplet excitons suppress nonradiative decays, as well facilitate efficient energy transfer from CA CNDs, thereby prolonging enhancing RTP. QY can be increased 26.89% (3.9‐fold increase) 951.25 ms (5.5‐fold increase), respectively, with incorporation 50 wt% under ambient conditions. Even fully environments (with up 400 added), exhibits persistent water‐boosted properties, demonstrating exceptional stability. property solutions presents potential for high signal‐to‐noise ratio afterglow bioimaging advanced information encryption.

Язык: Английский

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Photoactivated theranostic nanomaterials based on aggregation‐induced emission luminogens for cancer photoimmunotherapy

Deleted Journal, Год журнала: 2024, Номер 2(2)

Опубликована: Апрель 15, 2024

Abstract In this study, a series of high liposoluble near‐infrared emissive aggregation‐induced emission luminogens with triphenylamine derivatives as donor units and 1‐indanone electron acceptor are developed. Specifically, MTTOI has promising lipid droplets targeting ability viscosity‐response characteristics, it can monitor the viscosity fluctuations in living cells real time. It is found that able to fulfill activation apoptosis‐related signaling pathways under white light, also activate ferroptosis synergize apoptosis resulting tumor elimination. Interestingly, occurrence positively related enhancement immunogenic cell‐death effect, thus boosting infiltration CD8 + T reducing proportion regulatory by cooperating dendritic cells, which not only carry out primary antitumor treatment, but prevent metastasis through strong immunological memory effect. Moreover, vivo experimental results confirm successfully effectuates fatty liver tissue imaging. fluorescence signals be captured at site after 3 days administration due its fat‐solubility ease fusion tumors. This classic example could promote further development phototherapeutic agents preclinical research clinical applications.

Язык: Английский

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Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(18)

Опубликована: Фев. 19, 2024

The cell membrane is a crucial component of cells, protecting their integrity and stability while facilitating signal transduction information exchange. Therefore, disrupting its structure or impairing functions can potentially cause irreversible damage. Presently, the tumor recognized as promising therapeutic target for various treatment methods. Given extensive research focused on membranes, it both necessary timely to discuss these developments, from materials design specific biomedical applications. This review covers treatments based functional targeting membrane, ranging well-known membrane-anchoring photodynamic therapy recent lysosome-targeting chimaeras protein degradation. diverse mechanisms are introduced in following sections: phototherapy, self-assembly situ biosynthesis degradation proteins by chimeras. In each section, we outline conceptual general derived numerous studies, emphasizing representative examples understand advancements draw inspiration. Finally, some challenges future directions membrane-targeted our perspective. aims engage multidisciplinary readers encourage researchers related fields advance fundamental theories practical applications membrane-targeting agents.

Язык: Английский

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A Comprehensive Strategy Based on High Clinical Translational Nanosystem for Programmable Immunotherapy of Triple Negative Breast Cancer

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Март 23, 2024

Abstract Triple negative breast cancer (TNBCs), known as an immunologically cold tumor, is difficult to completely eliminate with existing monotherapies, let alone metastasis and recurrence. It urgent design a rational combination of multiple therapies programmatically reconstitute tumor microenvironment (TME) reverse the immune “cold” into “hot” inflammatory tumors improve therapeutic effect. Hence, in this work, multifunctional nanosystem (FeSH NPs) that integrates metal‐polyphenol coordination complex photothermal agent polyphenol, salvianolic acid B (SAB) immunomodulator designed fabricated for synergistic photothermal‐immunotherapy TNBCs combined anti‐PD‐L1 antibody. Guided by photothermal/photoacoustic dual‐mode imaging, therapy (PTT) caused FeSH NPs induces immunogenic cell death (ICD) under 808 nm laser irradiation. Subsequently, loaded SAB released addition deferoxamine mesylate (DFO) remodel TME, specifically TGF‐β inhibition PD‐L1 upregulation, primary tumors. The PTT TME reprogramming further synergizes antibody eradicate recurrence inhibit concurrently. Given biosafety throughout lifecycle, work provides protocol high clinical translational promise comprehensive programmed therapeutics TNBCs.

Язык: Английский

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Pyroptosis of Breast Cancer Stem Cells and Immune Activation Enabled by a Multifunctional Prodrug Photosensitizer

Advanced Functional Materials, Год журнала: 2024, Номер 34(37)

Опубликована: Апрель 23, 2024

Abstract Breast cancer stem cells (CSCs) are responsible for the occurrence, resistance, recurrence, invasion, and metastasis of tumors. However, even trace amounts CSCs may lead to tumor resistance which fundamentally reduces therapeutic efficiency numerous anticancer drugs. Thus, development a agent that can reduce tumorigenicity overcome recurrence is essential. Here novel multifunctional prodrug T‐P reported as photosensitizer, links phenothiazine drug with synthesized aggregation‐induced emission photosensitizer T‐C via an ester bond. Importantly, this found be able induce pyroptosis breast well activate their death pathway protein phosphatase 2A inhibit systemic anti‐tumor effects. rapidly target mitochondria overlap lysosomes after mitochondrial escape, it cause lysosomal dysfunction. It releases reactive oxygen species through photoactivation, triggering pyroptosis‐mediated strong immune response. On 5th day in vivo therapy cancer, primary eliminated growth distant tumors also inhibited. This research would provide impetus new strategy CSCs‐targeted photoimmunotherapy beyond.

Язык: Английский

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