Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(32), С. 17881 - 17891

Опубликована: Авг. 2, 2023

Atherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as heart attack and stroke, triggered by the decomposition fiber caps induced cysteine cathepsin. However, accurate measurement cathepsin B (CTB) activity in plaques challenging due to low specificity insufficient penetration depth available atherosclerosis-associated fluorescent probes, hampering reliable assessment vulnerability. To address these limitations, we added both lipophilic alkyl chain hydrophilic CTB substrate hemicyanine scaffold develop lipid-unlocked responsive probe (L-CRP) that uses lipids two keys unlock photoacoustic (PA) signals for measuring environments. Such properties allow L-CRP imaging specific activities foam cells atherosclerotic while keeping silence toward lipid-deficient environments, M1-type macrophages LPS-induced inflammatory lesions. Moreover, activatable PA exhibit deeper tissue ability (>1.0 cm) than current probes based on near-infrared (∼0.3 cm), suitable atherosclerosis living mice. In mice, dynamically reports intraplaque levels, which well-correlated with vulnerability characteristics cap thickness, macrophage recruitment, necrotic core size, thus enabling risk stratification mice complicated pneumonia. successfully identifies excised human artery tissues, promising auxiliary diagnosis clinical application.

Язык: Английский

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Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Advanced Materials, Год журнала: 2024, Номер 36(18)

Опубликована: Янв. 15, 2024

Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.

Язык: Английский

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Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Advanced Science, Год журнала: 2024, Номер 11(17)

Опубликована: Фев. 17, 2024

Abstract Atherosclerosis, a multifaceted chronic inflammatory disease, has profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include delayed detection advanced stages, intricate assessment plaque stability, and absence efficacious therapeutic strategies. Nanotheranostic based nanotechnology offers novel paradigm for addressing these challenges by amalgamating imaging capabilities with targeted interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates theranostic applications in due to their magnetic resonance capability biosafety. This review delineates current state prospects nanoparticle‐based nanotheranostics realm atherosclerosis, including pivotal aspects development, pertinent targeting strategies involved disease pathogenesis, diagnostic roles nanoparticles. Furthermore, this provides comprehensive overview nanomedicine approaches employing nanoparticles, encompassing chemical therapy, physical stimulation biological therapy. Finally, proposes discusses associated translating innovative into clinically viable anti‐atherosclerosis In conclusion, new insights future theranostic, showcasing remarkable potential oxide‐based versatile tools battle against atherosclerosis.

Язык: Английский

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Nanomedicine for Diagnosis and Treatment of Atherosclerosis

Advanced Science, Год журнала: 2023, Номер 10(36)

Опубликована: Окт. 28, 2023

Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and associated diseases have emerged as leading cause of death. Due to their fascinating physical, chemical, biological characteristics, nanomaterials are regarded a promising tool tackle enormous challenges in medicine. The emerging discipline nanomedicine filled huge application gap atherosclerotic field, ushering new generation diagnosis treatment strategies. Herein, based on essential pathogenic contributors atherogenesis, well distinct composition/structural synthesis strategies, surface design nanoplatforms, three major branches (nanodiagnosis, nanotherapy, nanotheranostic) elaborated. Then, state‐of‐art studies containing sequence representative significant achievements summarized detail with an emphasis intrinsic interaction/relationship between nanomedicines atherosclerosis. Particularly, attention is paid biosafety nanomedicines, which aims pave way for future clinical translation this burgeoning field. Finally, comprehensive review concluded by proposing unresolved key scientific issues sharing vision expectation future, fully elucidating closed loop from atherogenesis paradigm advancing early achievement applications.

Язык: Английский

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Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers

Exploration, Год журнала: 2023, Номер 4(3)

Опубликована: Дек. 7, 2023

Abstract Atherosclerosis, a chronic disease associated with metabolism, poses significant risk to human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface‐modified nanoparticles holds potential deliver highly effective therapeutic outcomes. These can target and bind specific receptors that are abnormally over‐expressed in atherosclerotic conditions. This paper reviews recent research (2018–present) advances various ligand‐modified nanoparticle systems targeting by specifically signature molecules hope precise treatment at molecular level concludes discussion challenges prospects this field. The intention review is inspire novel concepts design advancement targeted nanomedicines tailored atherosclerosis.

Язык: Английский

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Bioactive Phosphorus Dendrimers as a Universal Protein Delivery System for Enhanced Anti-inflammation Therapy

ACS Nano, Год журнала: 2024, Номер 18(3), С. 2195 - 2209

Опубликована: Янв. 9, 2024

Nanocarrier-based cytoplasmic protein delivery offers opportunities to develop therapeutics; however, many systems are positively charged, causing severe toxic effects. For enhanced therapeutics, it is also of great importance design nanocarriers with intrinsic bioactivity that can be integrated drugs due the limited proteins alone for disease treatment. We report here a system based on anionic phosphite-terminated phosphorus dendrimers anti-inflammatory activity. A dendrimer termed AK-137 optimized activity was selected complex through various physical interactions. Model such as bovine serum albumin, ribonuclease A, ovalbumin, and fibronectin (FN) transfected into cells exert their respective functions, including cancer cell apoptosis, dendritic maturation, or macrophage immunomodulation. Particularly, constructed AK-137@FN nanocomplexes display powerful therapeutic effects in acute lung injury gout arthritis models by integrating both carrier protein. The developed may employed universal particularly utilized deliver fight different inflammatory diseases efficacy.

Язык: Английский

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Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Апрель 2, 2024

Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection timely intervention of plaques are challenging due lack typical symptoms in initial stages. Therefore, precise early play a crucial role risk stratification achieving favorable post-interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal-to-noise ratio, enhanced bioavailability, specific targeting capabilities for imaging agents therapeutic drugs, enabling effective visualization management plaques. Motivated by these superior properties, various noninvasive modalities recognition preliminary stage atherosclerosis comprehensively summarized. Additionally, several strategies proposed enhance efficacy treating Finally, existing challenges promising prospects accelerating clinical translation nanoplatform-based molecular therapy discussed. In conclusion, this review provides an insightful perspective on diagnosis

Язык: Английский

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Comprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 9, 2024

Abstract Background Dry Eye Disease (DED) is a prevalent multifactorial ocular disease characterized by vicious cycle of inflammation, oxidative stress, and mitochondrial dysfunction on the surface, all which lead to DED deterioration impair patients’ quality life social functioning. Currently, anti-inflammatory drugs have shown promising efficacy in treating DED; however, such are associated with side effects. The bioavailability less than 5% owing factors as rapid tear turnover presence corneal barrier. This calls for investigations overcome these challenges drug administration. Results A novel hierarchical action liposome nanosystem (PHP-DPS@INS) was developed this study. In terms delivery, PHP-DPS@INS nanoparticles (NPs) overcame surface transport barrier adopting strategy “ocular electrostatic adhesion-lysosomal site-directed escape”. therapy, achieved targeting antioxidant effects through SS-31 peptide, exerted an effect loading insulin reduce inflammatory metabolites. Ultimately, synergistic “anti-inflammation-antioxidation-mitochondrial function restoration” breaks DED. demonstrated remarkable cellular uptake, lysosomal escape, vitro. Targeted metabolomics analysis revealed that effectively normalized elevated level proinflammatory metabolite fumarate vitro hypertonic model DED, thereby reducing levels key (IL-1β, IL-6, TNF-α). Additionally, strongly inhibited reactive oxygen species (ROS) production facilitated structural repair. vivo, treatment significantly enhanced adhesion duration permeability mice, improving bioavailability. It also restored secretion, suppressed damage, reduced inflammation mice. Moreover, it favorable safety profiles both vivo. Conclusion summary, study successfully comprehensive management transmission disrupted dry eye pathogenesis. pioneered regulation metabolites conditions, presenting safe, efficient, innovative therapeutic other diseases.

Язык: Английский

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ROS-responsive simvastatin nano-prodrug based on tertiary amine-oxide zwitterionic polymer for atherosclerotic therapy

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 6, 2025

Atherosclerosis (AS) is a major cause of cardiovascular disease and characterized by high levels reactive oxygen species (ROS) lipid deposition. This study utilized ROS-responsive oxalate bonds to conjugate simvastatin (SV) tertiary amine-oxide zwitterionic polymer (OPDH), resulting in the design nano-prodrug (OPDH-SV). In vitro experiments have proved that OPDH-SV has excellent stability low toxicity, can effectively reduce intracellular ROS levels, inhibit foam cells formation. addition, able achieve cell-to-cell transmission through cell's "endocytosis-efflux" mechanism target mitochondria. vivo further confirmed long-term circulation, targeted enrichment, reduction vivo. summary, good biosafety therapeutic effect, expected become new type anti-atherosclerotic nano-prodrug.

Язык: Английский

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