A Copper/Ferrous‐Engineering Redox Homeostasis Disruptor for Cuproptosis/Ferroptosis Co‐Activated Nanocatalytic Therapy in Liver Cancer

Advanced Functional Materials, Год журнала: 2024, Номер 34(37)

Опубликована: Апрель 25, 2024

Abstract Cuproptosis and ferroptosis hold great promise for overcoming apoptotic resistance in liver cancer based on their unique metal‐driven cell death modalities. However, insufficient intracellular copper iron concentration, complicated tumor microenvironment (TME), unclear cross‐regulatory mechanisms between cuproptosis ferroptosis, severely restrict the therapeutic performance. Herein, copper‐doped hollow Prussian blue (CHP) nanozymes are rationally designed loading photosensitizer indocyanine green (ICG) O 2 ‐saturated perfluorohexane (PFH), denoted as ‐PFH@CHPI nanoparticles, to induce ferroptosis. In response specific TME, CHP can synergistically catalyze Fenton reactions consume endogenous glutathione, leading accumulation of reactive oxygen species. Upon near‐infrared irradiation, ‐PFH@CHPI‐enabled photothermal effect simultaneously accelerate catalytic trigger release photodynamic therapy promote oxidative stress. Notably, be effectively activated through Cu + ‐mediated dihydrolipoamide S‐acetyltransferase aggregation Fe–S cluster protein loss. Concurrently, tilt redox balance is favorable lipid peroxidation glutathione peroxidase 4 inactivation, resulting an augmented effect. Mechanistically, stress‐boosted jointly disrupt mitochondrial metabolism, which turn exacerbates stress, thus realizing a mutually enhanced This work may provide new guidance utilizing copper/ferrous‐engineering cuproptosis/ferroptosis synergetic therapy.

Язык: Английский

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Dynamic defects boost in-situ H ₂ O ₂ piezocatalysis for water cleanup

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(9)

Опубликована: Фев. 20, 2024

Creating efficient catalysts for simultaneous H 2 O generation and pollutant degradation is vital. Piezocatalytic synthesis offers a promising alternative to traditional methods but faces challenges like sacrificial reagents, harsh conditions, low activity. In this study, we introduce cobalt-loaded ZnO (CZO) piezocatalyst that efficiently generates from under ultrasonic (US) treatment in ambient aqueous conditions. The catalyst demonstrates exceptional performance with ~50.9% TOC removal of phenol situ 1.3 mM , significantly outperforming pure ZnO. Notably, the CZO maintains its capability even after multiple cycles, showing continuous improvement (from 1.8 mM). This attributed piezoelectric electrons promoting dynamic defects US which turn promotes adsorption activation oxygen, thereby facilitating production, as confirmed by EPR spectrometry, XPS analysis, DFT calculations. Moreover, piezocatalysts maintain outstanding production long periods inactivity, deactivated due metal ion dissolution could be rejuvenated pH adjustment, offering sustainable solution wastewater purification.

Язык: Английский

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Doping Engineering of Piezo‐Sonocatalytic Nanocoating Confer Dental Implants with Enhanced Antibacterial Performances and Osteogenic Activity

Advanced Functional Materials, Год журнала: 2024, Номер 34(21)

Опубликована: Янв. 30, 2024

Abstract Rescuing dental implants from plaque‐induced infection and implementing effective plaque control methods in a limited oral environment pose challenges for modern dentistry. To address this issue, Al ion doped strontium titanate/titanium dioxide nanotubes (Al‐SrTiO 3 /TiO 2 nanotubes, Al‐STNT) are designed as an ultrasound‐responsive nanocoating immobilized on the Ti implant surface. Introducing 3+ ions into inorganic sonosensitive SrTiO heterojunction induces oxygen vacancies disrupts lattice of . By overcoming bandgap barrier through ultrasonic stimulated piezoelectric effect, Al‐STNT produces more reactive species (ROS). In sonodynamic therapy (SDT) process, stimulus abundant ROS efficiently disrupting bacteria biofilm inhibiting metabolism. Moreover, specific nanoscale coating endows with osteogenic activity, facilitating formation rigid osseointegration between surface alveolar bone. mimicking human rats, demonstrates optimal postimplant while retaining its antibacterial ability sonosensitizer. Thanks to portability ultrasound instrument stability implant‐based sonosensitizer, strategy presents attractive option patients self‐treat secure long‐term success their implants.

Язык: Английский

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In-suit generated Cu-ligand inducing full-spectrum selective photocatalytic degradation of organic pollutants containing phenol groups over Cu doping BiO2-x nanosheet: The synergistic effects of Cu-ligand and oxygen vacancies, and mechanism study

Chemical Engineering Journal, Год журнала: 2024, Номер 499, С. 155810 - 155810

Опубликована: Сен. 16, 2024

Язык: Английский

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A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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Defect‐Engineered Biomimetic Piezoelectric Nanocomposites With Enhanced ROS Production, Macrophage Re‐polarization, and Ca²⁺ Channel Activation for Therapy of MRSA‐Infected Wounds and Osteomyelitis

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure antibiotics resistant leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with penetration. Currently, PZDT demands further investigation for improved treatment outcomes corresponding therapeutic mechanisms. Herein, a nanocomposite cloaked is reported biomimetic coating TLR-upregulated macrophage membrane targeted against MRSA-induced skin wound infection osteomyelitis, representing models, respectively. To boost efficacy, crystal defect engineering applied by impregnating Fe2+ into bismuth oxy-iodide nanosheets increase defects. This results significantly higher piezoelectric coefficient than previous reports, contributing an amplified reactive oxygen species generation bacterial killing. More importantly, notable effect not only re-programs macrophages anti-inflammatory M2 phenotype accelerating healing but also stimulates opening piezo-stimulated Ca2+ channels boosts differentiation mesenchymal stem cells osteoblasts expediting bone tissue repair osteomyelitis model. Moreover, Fe-doping supplements T2-magnetic resonance imaging real-time visualization distribution. theranostic system opens new avenue future drug-resistant bacteria-caused diseases.

Язык: Английский

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In Situ Attached Photothermal Immunomodulation-Enhanced Nanozyme for the Inhibition of Postoperative Malignant Glioma Recurrence

ACS Nano, Год журнала: 2023, Номер 17(14), С. 13885 - 13902

Опубликована: Июль 3, 2023

Glioblastoma (GBM) is one of the most challenging malignant brain tumors to treat. Herein, we describe a nanoenzyme hemostatic matrix strategy with tumor cavity in situ application that simultaneously serves as photothermal agent and induces immunogenic cell death after GBM surgical resection enhance antitumor immunity delay recurrence. The system (Surgiflo@PCN) contains Surgiflo, multispace structure can be used penetrate different shapes cavities prevent postoperative hemorrhage. As well, porous palladium–copper nanoclusters (PCNs) have adjustable enzyme-like activities (oxidase, peroxidase, catalase) responsible for formation reactive oxygen species (ROS) under near-infrared (808 nm) laser irradiation. When Surgiflo@PCN entered resected cavity, first action was direct killing glioma cells via ROS therapy (PTT). second induction by PCN-enhanced oxidative stress PTT, which reversed immunosuppressive microenvironment enhanced immune response. This eradicated residual prevented collective findings demonstrate kills directly through PTT enhances antiglioma indirectly. "one-stone, two-birds" could become an effective immunotherapy patients.

Язык: Английский

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Peptide‐Appended Nanosonosensitizers Targeting Tumor Glycolysis for Synergistic Sonodynamic–Immunometabolic Therapy of Spinal‐Metastasized Tumors

Advanced Materials, Год журнала: 2023, Номер 35(42)

Опубликована: Июль 18, 2023

Despite recent advancements in cancer immunotherapy, challenges have yet to be surmounted achieve two major goals of magnifying antitumor immunity and remodeling the immunosuppressive tumor microenvironment. Here, a nanosystem (ODM-R) that integrates oxygen-deficient molybdenum oxide (ODM) nanosonosensitizers R7 peptides with metabolism regulation effects is designed fabricated for synergistic sonodynamic-immunometabolic therapy spinal-metastasized tumors. The ODM generates reactive oxygen species upon ultrasound irradiation implement sonodynamic (SDT), inducing cell apoptosis immunogenic death. attached on markedly inhibits uptake glucose excretion lactic acid cells by perturbing glycolysis process. combination SDT obstruction ODM-R guarantees satisfactory efficacy synergizing PD-L1 antibody eradicate tumors, achieving concurrent sonodynamic-triggered immune activation microenvironment remodeling. This work provides proof-of-concept boosting immunotherapy metabolic regulation.

Язык: Английский

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Palladium‐Catalyzed Hydrogenation of Black Barium Titanate for Multienzyme‐Piezoelectric Synergetic Tumor Therapy

Advanced Materials, Год журнала: 2023, Номер 36(9)

Опубликована: Окт. 5, 2023

Abstract Piezocatalytic tumor therapy is an emerging reactive oxygen species (ROS)‐generating therapeutic approach that relies on piezoelectric polarization under ultrasound (US) irradiation. Optimizing ROS production a primary objective for enhancing treatment efficiency. In this study, oxygen‐vacancy‐rich Pd‐integrated black barium titanate (BTO) nanoparticles are rationally engineered to boost the generation efficiency via introduction of Pd. Pd‐catalyzed hydrogenation at low temperatures narrows bandgap BTO and reduces recombination rate electron‐hole pairs. Furthermore, Pd has dual‐enzyme‐mimicking characteristics, including peroxidase‐ catalase‐mimicking activities, which further heighten efficacy by reversing hypoxic microenvironment. Importantly, dual enzymatic activity can be amplified multiple redox processes sparked potential US stimulation, resulting in bilaterally enhanced multienzyme‐piezoelectric synergetic therapy. vitro vivo results confirm high inhibition murine breast cancer cells. This work stresses critical effects defect engineering‐optimized piezodynamic

Язык: Английский

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A mild and efficient sonothermal tumor therapy enhanced by sonodynamic effect with biodegradable red phosphorus nanoparticles

Chemical Engineering Journal, Год журнала: 2024, Номер 482, С. 148711 - 148711

Опубликована: Янв. 12, 2024

Язык: Английский

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