Abstract
Wounds
and
the
subsequent
formation
of
scars
constitute
a
unified
complex
phased
process.
Effective
treatment
is
crucial;
however,
diverse
therapeutic
approaches
for
different
wounds
scars,
as
well
varying
needs
at
stages,
present
significant
challenges
in
selecting
appropriate
interventions.
Microneedle
patch
(MNP),
novel
minimally
invasive
transdermal
drug
delivery
system,
has
potential
integrated
programmed
various
diseases
shown
promising
applications
types
scars.
In
this
comprehensive
review,
latest
biotechnological
innovations
MNPs
these
fields
are
thoroughly
explored,
summarizing
their
powerful
abilities
to
accelerate
healing,
inhibit
scar
formation,
manage
related
symptoms.
Moreover,
scenarios
discussed.
Additionally,
side
effects,
manufacturing
processes,
material
selection
explore
clinical
translational
investigated.
This
groundwork
can
provide
theoretical
basis
serve
catalyst
future
pursuit
favorable
options
skin
tissue
regeneration.
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 13, 2024
Owing
to
the
increased
tissue
iron
accumulation
in
patients
with
diabetes,
microorganisms
may
activate
high
expression
of
iron-involved
metabolic
pathways,
leading
exacerbation
bacterial
infections
and
disruption
systemic
glucose
metabolism.
Therefore,
an
on-demand
transdermal
dosing
approach
that
utilizes
homeostasis
regulation
combat
antimicrobial
resistance
is
a
promising
strategy
address
challenges
associated
low
administration
bioavailability
antibiotic
treating
infected
diabetic
wounds.
Here,
it
aimed
propose
effective
therapy
based
on
hemoglobin
bionics
induce
disturbances
homeostasis.
The
preferred
"iron
cargo"
synthesized
by
protoporphyrin
IX
chelated
dopamine
gallium
(PDGa),
delivered
via
glucose/pH-responsive
microneedle
bandage
(PDGa@GMB).
PDGa@GMB
downregulates
levels
uptake
regulator
(Fur)
peroxide
response
(perR)
Staphylococcus
aureus,
nutrient
starvation
oxidative
stress,
ultimately
suppressing
iron-dependent
activities.
Consequently,
demonstrates
insusceptibility
genetic
while
maintaining
sustainable
effects
(>90%)
against
resistant
strains
both
S.
aureus
E.
coli,
accelerates
recovery
(<20
d).
Overall,
not
only
counteracts
but
also
holds
tremendous
potential
mediating
microbial-host
crosstalk,
synergistically
attenuating
pathogen
virulence
pathogenicity.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 31, 2024
Photonic
crystals
are
a
new
class
of
optical
microstructure
materials
characterized
by
dielectric
constant
that
varies
periodically
with
space
and
features
photonic
bandgap.
Inspired
natural
such
as
butterfly
scales,
series
artificial
developed
for
use
in
integrated
platforms,
biosensing,
communication,
other
fields.
Among
them,
colloidal
(CPCs)
have
gained
widespread
attention
due
to
their
excellent
properties
advantages,
ease
preparation
functionalization.
This
work
reviews
the
classification
self-assembly
principles
CPCs,
details
some
latest
biomedical
applications
large-area,
high-quality
CPCs
prepared
using
advanced
methods,
summarizes
existing
challenges
CPC
construction
application,
anticipates
future
development
directions
optimization
strategy.
With
further
advancements,
expected
play
more
critical
role
biosensors,
drug
delivery,
cell
research,
fields,
bringing
significant
benefits
research
clinical
practice.
Abstract
Topical
antibiotics
can
be
utilized
to
treat
periodontitis,
while
their
delivery
stratagems
with
controlled
release
and
long‐lasting
bactericidal
inhibition
are
yet
challenging.
Herein,
inspired
by
the
defensive
behavior
of
cuttlefish
expelling
ink,
this
work
develops
innovative
thermal‐responsive
melanin‐integrated
porous
microparticles
(MPs)
through
microfluidic
synthesis
for
periodontitis
treatment.
These
MPs
composed
melanin
nanoparticles
(NPs),
poly(N‐isopropylacrylamide)
(PNIPAM),
agarose.
Benefiting
from
excellent
biocompatibility
large
surface
area
ratio
MPs,
they
deliver
abundant
NPs.
Under
near‐infrared
irradiation,
NPs
convert
photo
energy
into
thermal
energy.
This
leads
agarose
melting
subsequent
shrinkage
microspheres
induced
pNIPAM,
thereby
facilitating
In
addition,
released
serve
as
a
highly
effective
photothermal
agent,
displaying
potent
antibacterial
activity
against
porphyromonas
gingivalis
possessing
natural
anti‐inflammatory
properties.
unique
characteristics
further
demonstrated
in
vivo
experiments,
showing
effects
treatment
infected
wounds
periodontitis.
Therefore,
catfish‐inspired
photo‐responsive
controlled‐release
drug
hold
tremendous
potential
clinical
applications.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 27, 2024
Abstract
Photodynamic
therapy
(PDT)
continues
to
encounter
multifarious
hurdles,
stemming
from
the
ineffectual
preservation
and
delivery
system
of
photosensitizers,
dearth
imaging
navigation,
antioxidant/hypoxic
tumor
microenvironment.
Herein,
a
versatile
cryomicroneedle
patch
(denoted
as
CMN‐CCPH)
is
developed
for
traceable
PDT.
The
therapeutic
efficacy
further
amplified
by
catalase
(CAT)‐induced
oxygen
(O
2
)
generation
Cu
2+
‐mediated
glutathione
(GSH)
depletion.
CMN‐CCPH
composed
(CMN)
vehicle
CAT‐biomineralized
copper
phosphate
nanoflowers
(CCP
NFs)
loaded
with
hematoporphyrin
monomethyl
ether
(HMME)
payload.
Importantly,
bioactive
function
HMME
CAT
can
be
optimally
maintained
under
protection
CCPH
CMN
duration
surpassing
60
days,
leading
bolstered
bioavailability
notable
enhancements
in
PDT
efficacy.
vivo
visualization
oxyhemoglobin
saturation
(sO
monitored
fluorescence
(FL)/photoacoustic
(PA)
duplex
real‐time
unveils
noteworthy
implications
CMN‐delivered
intratumoral
enrichment
O
reduced
systemic
toxicity.
This
demonstrates
distinct
effectiveness
neoplasm
elimination,
underscoring
its
promising
clinical
prospects.
Journal of Controlled Release,
Год журнала:
2024,
Номер
374, С. 76 - 88
Опубликована: Авг. 10, 2024
The
retinoid
fenretinide
(FENR)
is
a
promising
compound
for
preventing
breast
cancer
recurrence
but
faces
challenges
due
to
poor
solubility
and
low
bioavailability.
This
study
explores
the
development
of
dissolving
microneedles
(MNs)
containing
FENR-loaded
ethosomes
minimally
invasive
chemoprevention,
aiming
enhance
local
drug
distribution.
Ethosomes
were
formulated
using
ethanol,
propylene
glycol,
soya
lecithin,
water,
polysorbate
80
micelles.
MNs
created
from
poly(vinyl
alcohol)
poly(vinylpyrrolidone)
hydrogels
by
adding
polymer
powder
directly
into
suspensions,
reducing
manufacturing
time
cost.
Two
methods
used
load
high-density
moulds:
1)
only
in
needle
area,
2)
both
area
baseplate.
Dynamic
light
scattering
confirmed
nanostructures
MNs.
Micelle-based
dissolved
15
min,
compared
30
min
other
Skin
deposition
studies
showed
greater
(up
10
μg/patch)
enhanced
skin
permeation
FENR
40
μg)
with
Method
2.
In-vivo
rats
demonstrated
that
oral
administration
resulted
plasma
levels
below
ng/g
first
three
hours,
whereas
MN
delayed
delivery,
reaching
maximum
concentration
52
at
48
h.
decreased
3
μg/g
on
day
1
<0.3
last
day.
indicates
are
potential
dosage
form
delivering
FENR,
offering
new
approach
chemoprevention.
World Journal of Stem Cells,
Год журнала:
2024,
Номер
16(4), С. 334 - 352
Опубликована: Апрель 24, 2024
Wound
repair
is
a
complex
challenge
for
both
clinical
practitioners
and
researchers.
Conventional
approaches
wound
have
several
limitations.
Stem
cell-based
therapy
has
emerged
as
novel
strategy
to
address
this
issue,
exhibiting
significant
potential
enhancing
healing
rates,
improving
quality,
promoting
skin
regeneration.
However,
the
use
of
stem
cells
in
regeneration
presents
challenges.
Recently,
biomaterials
been
identified
crucial
components
wound-healing
process.
Combination
involving
development
biocompatible
scaffolds,
accompanying
cells,
multiple
biological
factors,
structures
resembling
natural
extracellular
matrix
(ECM)
gained
considerable
attention.
Biological
scaffolds
encompass
range
that
serve
platforms
seeding
providing
them
with
an
environment
conducive
growth,
similar
ECM.
These
facilitate
delivery
application
tissue
healing.
This
article
provides
comprehensive
review
current
developments
applications
healing,
emphasizing
their
capacity
cell
adhesion,
proliferation,
differentiation,
paracrine
functions.
Additionally,
we
identify
pivotal
characteristics
contribute
enhanced
cellular
activity.
