An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 6, 2024

Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at addressing both these simultaneously interrupt this detrimental Herein, an immunomodulatory hydrogel (PHG2) developed for reshaping hostile microenvironment. The engineered PHG2 only removes excess internally‐produced ROS but also generates O 2 , with its efficiency further boosted by local hyperthermia (42.5 °C) activated near‐infrared light. Through vitro vivo studies, along transcriptomic assessment, it confirmed that disrupts feedback loop between inflammation while lowering M1/M2 ratio. Such discoveries contribute significant enhancement healing process injuries undergo gradual increase movement, covering wounds from back, mouth, foot. Ultimately, method provides easy, safe, highly effective solution treating DFUs.

Язык: Английский

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A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers

ACS Materials Letters, Год журнала: 2024, Номер 6(7), С. 2533 - 2547

Опубликована: Май 24, 2024

Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing

Язык: Английский

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Hydrogel-Based Skin Regeneration

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 1982 - 1982

Опубликована: Фев. 6, 2024

The skin is subject to damage from the surrounding environment. repair of wounds can be very challenging due several factors such as severe injuries, concomitant infections, or comorbidities diabetes. Different drugs and wound dressings have been used treat wounds. Tissue engineering, a novel therapeutic approach, revolutionized treatment regeneration tissue damage. This field includes use synthetic natural biomaterials that support growth tissues organs outside body. Accordingly, demand for polymer-based strategies defects significantly increasing. Among various 3D scaffolds in hydrogel gained special significance their unique properties mimicry extracellular matrix (ECM), moisture retention, porosity, biocompatibility, biodegradability, biocompatibility properties. First, this article delineates process healing conventional methods treating It then presents an examination structure manufacturing hydrogels, followed by analysis crucial characteristics most recent advancements using purpose. Finally, it discusses potential future materials within realm healing.

Язык: Английский

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Modulating macrophage phenotype for accelerated wound healing with chlorogenic acid-loaded nanocomposite hydrogel

Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 420 - 443

Опубликована: Апрель 5, 2024

Язык: Английский

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Glucose-Responsive hydrogel optimizing Fenton reaction to eradicate multidrug-resistant bacteria for infected diabetic wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150545 - 150545

Опубликована: Март 19, 2024

Язык: Английский

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Multifunctional PDA/ZIF8 based hydrogel dressing modulates the microenvironment to accelerate chronic wound healing by ROS scavenging and macrophage polarization

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150632 - 150632

Опубликована: Март 24, 2024

Язык: Английский

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A cuttlefish ink nanoparticle-reinforced biopolymer hydrogel with robust adhesive and immunomodulatory features for treating oral ulcers in diabetes

Bioactive Materials, Год журнала: 2024, Номер 39, С. 562 - 581

Опубликована: Май 30, 2024

Oral ulcers can be managed using a variety of biomaterials that deliver drugs or cytokines. However, many patients experience minimal benefits from certain medical treatments because poor compliance, short retention times in the oral cavity, and inadequate drug efficacy. Herein, we present novel hydrogel patch (SCE2) composed biopolymer matrix (featuring ultraviolet-triggered adhesion properties) loaded with cuttlefish ink nanoparticles (possessing pro-healing functions). Applying straightforward local method initiates formation barrier adheres to mucosal injuries under influence ultraviolet light. SCE2 then demonstrates exceptional capabilities for near-infrared photothermal sterilization neutralization reactive oxygen species. These properties contribute elimination bacteria management oxidation process, thus accelerating healing phase's progression inflammation proliferation. In studies involving diabetic rats ulcers, adhesive significantly quickens recovery by altering inflamed state injured area, facilitating rapid re-epithelialization, fostering angiogenesis. conclusion, this light-sensitive offers promising path expedited wound healing, potentially transforming treatment strategies clinical ulcers.

Язык: Английский

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Immunomodulatory melanin@Pt nanoparticle-reinforced adhesive hydrogels for healing diabetic oral ulcers

Chemical Engineering Journal, Год журнала: 2024, Номер 488, С. 150372 - 150372

Опубликована: Март 27, 2024

Язык: Английский

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Multifunctional hydrogels-based therapies for chronic diabetic wound healing

European Polymer Journal, Год журнала: 2024, Номер 211, С. 113026 - 113026

Опубликована: Апрель 8, 2024

Chronic diabetic wounds persist as a healthcare challenge and therefore require the use of innovative therapeutic approaches. Among emerging solutions, hydrogels stand out promising avenue for wound healing due to their unique properties versatile applications, capable addressing complex challenging microenvironment that characterizes such wounds. In this work, through detailed analysis relevant experimental studies, we highlight multifunctionality hydrogels, namely ability promote tissue attachment, prevent scarring, fight infection, attenuate inflammation, facilitate electrical signaling, control bleeding, repair damage autonomously, exhibit responses tailored specific characteristics. The collective findings from these studies emphasize attributes in challenges. By elucidating crucial insights, work seeks lay groundwork both academics industries development implementation effective hydrogel-based strategies can significantly improve outcomes, offering new hope patients suffering chronic

Язык: Английский

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MOF/MXene-loaded PVA/chitosan hydrogel with antimicrobial effect and wound healing promotion under electrical stimulation and improved mechanical properties

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130625 - 130625

Опубликована: Март 6, 2024

Язык: Английский

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