Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology

Advanced Materials, Год журнала: 2024, Номер 36(35)

Опубликована: Июнь 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Язык: Английский

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Advances in electroactive biomaterials: Through the lens of electrical stimulation promoting bone regeneration strategy

Journal of Orthopaedic Translation, Год журнала: 2024, Номер 47, С. 191 - 206

Опубликована: Июнь 27, 2024

The regenerative capacity of bone is indispensable for growth, given that accidental injury almost inevitable. Bone relevant the aging population globally and repair large defects after osteotomy (e.g., following removal malignant tumours). Among many therapeutic modalities proposed to regeneration, electrical stimulation has attracted significant attention owing its economic convenience exceptional curative effects, various electroactive biomaterials have emerged. This review summarizes current knowledge progress regarding strategies improving repair. Such range from traditional methods delivering via electroconductive materials using external power sources self-powered biomaterials, such as piezoelectric nanogenerators. Electrical osteogenesis are related piezoelectricity. examines cell behaviour potential mechanisms electrostimulation in healing, aiming provide new insights regeneration biomaterials. roles rehabilitating microenvironment facilitate addressing whereby cues mediate regeneration. Interactions between osteogenesis-related cells summarized, leading proposals use stimulation-based therapies accelerate healing.

Язык: Английский

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Surface Oxygen Vacancies and Corona Polarization of Bi₄Ti₃O₁₂ Nanosheets for Synergistically Enhanced Sonopiezoelectric Therapy

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(32), С. 22348 - 22359

Опубликована: Авг. 1, 2024

Sonopiezoelectric therapy, an ultrasound-activated piezoelectric nanomaterial for tumor treatment, has emerged as a novel alternative modality. However, the limited catalytic efficiency is serious bottleneck its practical application. Excellent catalysts with high coefficients, good deformability, large mechanical impact surface area, and abundant catalytically active sites still need to be developed urgently. In this study, classical ferroelectric material, bismuth titanate (Bi4Ti3O12, BTO), selected sonopiezoelectric sensitizer therapy. BTO generates electron–hole pairs under ultrasonic irradiation, which can react substrates in sonocatalytic-driven redox reaction. Aiming further improve activity of BTO, modification oxygen vacancies treatment corona polarization are envisioned study. Notably, reduces bandgap inhibits recombination. Additionally, immobilized built-in electric field on promoting separation electrons holes. Consequently, these modifications greatly sonocatalytic situ generation cytotoxic ROS CO, effectively eradicating tumor.

Язык: Английский

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Recent advances using MXenes in biomedical applications

Materials Horizons, Год журнала: 2023, Номер 11(4), С. 876 - 902

Опубликована: Дек. 1, 2023

The structure of this review includes applications MXenes in drug delivery, tissue engineering, antimicrobial, and biosensors.

Язык: Английский

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A Janus nanofibrous scaffold integrated with exercise-driven electrical stimulation and nanotopological effect enabling the promotion of tendon-to-bone healing

Nano Today, Год журнала: 2024, Номер 55, С. 102208 - 102208

Опубликована: Фев. 29, 2024

Язык: Английский

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Small, Год журнала: 2024, Номер 20(44)

Опубликована: Июль 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Язык: Английский

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Piezoelectric Scaffolds as Smart Materials for Bone Tissue Engineering

Polymers, Год журнала: 2024, Номер 16(19), С. 2797 - 2797

Опубликована: Окт. 2, 2024

Bone repair and regeneration require physiological cues, including mechanical, electrical, biochemical activity. Many biomaterials have been investigated as bioactive scaffolds with excellent electrical properties. Amongst biomaterials, piezoelectric materials (PMs) are gaining attention in biomedicine, power harvesting, biomedical devices, structural health monitoring. PMs unique properties, such the ability to affect movements deliver stimuli damaged bone or cells without an external source. The crucial property is its piezoelectricity. Bones can generate charges potential response mechanical stimuli, they influence growth regeneration. Piezoelectric respond human microenvironment important factor repair. This manuscript overview of fundamentals generating effect their on paper focuses state art materials, polymers, ceramics, composites, application tissue engineering. We present information from point view highlight promising upcoming approaches new generations materials.

Язык: Английский

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Advances in Gelatin-based Scaffolds for Tissue Engineering Applications: A Review

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106789 - 106789

Опубликована: Март 1, 2025

Язык: Английский

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Low‐Frequency Ultrasound Sensitive Piezo1 Channels Regulate Keloid‐Related Characteristics of Fibroblasts

Advanced Science, Год журнала: 2024, Номер 11(14)

Опубликована: Фев. 4, 2024

Abstract Keloids are benign fibroproliferative tumors that severely diminish the quality of life due to discomfort, dysfunction, and disfigurement. Recently, ultrasound technology as a noninvasive adjuvant therapy is developed optimize treatment protocols. However, biophysical mechanisms have not yet been fully elucidated. Here, it proposed piezo‐type mechanosensitive ion channel component 1 (Piezo1) plays an important role in low‐frequency sonophoresis (LFS) induced mechanical transduction pathways trigger downstream cellular signaling processes. It demonstrated patient‐derived primary keloid fibroblasts (PKF), NIH 3T3, HFF‐1 cell migration inhibited, PKF apoptosis significantly increased by LFS stimulation. And effects diminished application GsMTx‐4, selective inhibitor Piezo1, knockdown Piezo1. More importantly, can be imitated Yoda1, agonist Piezo1 channels. Establishing xenograft implantation mouse model further verified these results, decreased volume weight keloids. Moreover, blocking impaired effectiveness treatment. These results suggest inhibits malignant characteristics keloids activating channel, thus providing theoretical basis for improving clinical

Язык: Английский

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Poly(Lactic Acid): Recent Stereochemical Advances and New Materials Engineering

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 17, 2024

Poly(lactic acid) (PLA) is a representative biobased and biodegradable aliphatic polyester front-runner among sustainable materials. As semicrystalline thermoplastic, PLA exhibits excellent mechanical physical properties, attracting considerable attention in commodity medical fields. Stereochemistry key factor affecting PLA's to this end, the engineering of microstructure for tailored material properties has been an active area research over decade. This Review first covers basic structural variety PLA. A perspective on current states stereocontrolled synthesis as well relationships between structures stereosequences are included, with emphasis record regularity properties. At last, state-of-the-art examples high-performance PLA-based materials within array applications given, including packaging, fibers, textiles, healthcare electronic devices. Among various stereo-regular sequences PLA, poly(L-lactic (PLLA) most prominent category myriad unique applications. In regard, cutting-edge PLLA mainly overviewed review. same time, new developed based other highlighted, which holds potential wide

Язык: Английский

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