International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
266, С. 131277 - 131277
Опубликована: Март 31, 2024
Bacteria-infected
wound
healing
has
attracted
widespread
attention
in
biomedical
engineering.
Wound
dressing
is
a
potential
strategy
for
repairing
infectious
wounds.
However,
the
development
of
with
appropriate
physiochemical,
antibacterial,
and
hemostatic
properties,
remains
challenging.
Hence,
there
motivation
to
develop
new
synthetic
dressings
improve
bacteria-infected
healing.
Here,
we
fabricate
biocompatible
sponge
through
covalent
crosslinking
collagen
(Col),
quaternized
chitosan
(QCS),
graphene
oxide
(GO).
The
resulting
Col-QCS-GO
shows
an
elastic
modulus
1.93-fold
higher
than
Col
due
enhanced
degree
by
GO
incorporation.
Moreover,
fabricated
favorable
porosity
(84.30
±
3.12
%),
water
absorption/retention
(2658.0
113.4
%/1114.0
65.7
hemostasis
capacities
(blood
loss
<50.0
mg).
Furthermore,
antibacterial
property
under
near-infrared
(NIR)
irradiation
significantly
(the
inhibition
rates
are
99.9
%
S.
aureus
E.
coli)
inherent
properties
QCS
photothermal
capabilities
GO.
Finally,
Col-QCS-GO+NIR
exhibits
lowest
percentage
area
(9.05
1.42
%)
at
day
14
compared
control
group
(31.61
1.76
%).
This
study
provides
insights
developing
innovative
sponges
Bioactive Materials,
Год журнала:
2023,
Номер
30, С. 129 - 141
Опубликована: Июль 28, 2023
In
clinical
applications,
there
is
a
lack
of
wound
dressings
that
combine
efficient
resistance
to
drug-resistant
bacteria
with
good
self-healing
properties.
this
study,
series
adhesive
conductive
antibacterial
hydrogel
based
on
oxidized
sodium
alginate-grafted
dopamine/carboxymethyl
chitosan/Fe3+
(OSD/CMC/Fe
hydrogel)/polydopamine-encapsulated
poly(thiophene-3-acetic
acid)
(OSD/CMC/Fe/PA
hydrogel)
were
prepared
for
the
repair
infected
wound.
The
Schiff
base
and
Fe3+
coordination
bonds
structure
are
dynamic
can
be
repaired
automatically
after
network
disrupted.
Macroscopically,
exhibits
properties,
allowing
dressing
adapt
complex
surfaces.
OSD/CMC/Fe/PA
showed
conductivity
photothermal
properties
under
near-infrared
(NIR)
light
irradiation.
addition,
hydrogels
exhibit
tunable
rheological
suitable
mechanical
antioxidant
tissue
adhesion
hemostatic
Furthermore,
all
improved
healing
in
full-thickness
defect
skin
test
mice.
size
by
OSD/CMC/Fe/PA3
+
NIR
was
much
smaller
(12%)
than
control
group
treated
Tegaderm™
film
14
days.
conclusion,
have
high
efficiency,
conductivity,
great
biocompatibility,
hemostasis
making
them
promising
candidates
treatment
wounds.
Materials & Design,
Год журнала:
2023,
Номер
233, С. 112231 - 112231
Опубликована: Авг. 9, 2023
Bacterial
infection
continues
to
be
one
of
the
biggest
threats
human
health.
The
therapeutic
effect
is
significantly
reduced
as
a
result
development
super-bacteria-resistant
bacteria
due
overuse
antibiotics
for
conventional
antimicrobial
treatment.
emergence
drug-resistant
makes
it
necessary
develop
new
treatments.
Following
successful
application
photothermal
therapy
in
field
oncology
treatment,
more
and
researchers
are
applying
treatments
achieving
important
results,
especially
treatment
bacterial
infections.
As
non-invasive
anti-infection
method,
has
advantages
broad-spectrum
properties,
short
period,
low
systemic
impact.
In
PTT,
efficacy
strongly
depends
on
different
laser
properties
choice
agents
(PTAs).
purpose
this
review
discuss
most
recent
developments
nanomaterials
that
antibacterial.
We
will
delve
into
principles
spectrum
PTAs
provide
summary
current
synthesis,
classification,
structural
features,
physicochemical
antibacterial
performance
research.
challenges
future
prospects
enhanced
cytotoxicity
investigated.
Carbon,
Год журнала:
2024,
Номер
223, С. 118970 - 118970
Опубликована: Фев. 26, 2024
Hydrogel-integrated
graphene
superstructures
(GSSs)
represent
a
promising
platform
for
applications
in
tissue
engineering
and
regenerative
medicine.
Graphene,
two-dimensional
carbon-based
material,
possesses
remarkable
mechanical,
thermal,
electrical
characteristics,
making
it
strong
candidate
application
biomedicine.
Researchers
have
pursued
the
integration
of
with
hydrogels,
known
their
biocompatibility
ability
to
provide
conducive
environment
cellular
growth,
craft
sophisticated
scaffolds
tailored
needs.
The
hydrogels
enables
construction
3D
frameworks
that
closely
mimic
natural
extracellular
matrix
(ECM)
found
biological
tissues.
Hydrogels
furnish
biocompatible,
well-hydrated
environment,
while
component
bolsters
scaffold's
mechanical
integrity
conductivity.
This
amalgamation
enhances
adhesion,
differentiation,
proliferation,
thereby
facilitating
regeneration.
A
notable
advantage
hydrogel-integrated
GSSs
lies
capacity
support
growth
differentiation
variety
cell
types
such
as
PC12,
MG-63,
U-87,
MC3T3-E1
lines.
Overall,
exhibit
great
potential
advancing
biomimetic
combination
unique
properties
development
advanced
scaffold
systems
Further
research
this
domain
will
play
crucial
role
medicine
treatment
various
diseases
injuries.
ACS Nano,
Год журнала:
2024,
Номер
18(22), С. 14085 - 14122
Опубликована: Май 22, 2024
Infectious
diseases
pose
a
serious
threat
and
substantial
economic
burden
on
global
human
public
health
security,
especially
with
the
frequent
emergence
of
multidrug-resistant
(MDR)
bacteria
in
clinical
settings.
In
response
to
this
urgent
need,
various
photobased
anti-infectious
therapies
have
been
reported
lately.
This
Review
explores
discusses
several
photochemical
targeted
antibacterial
therapeutic
strategies
for
addressing
bacterial
infections
regardless
their
antibiotic
susceptibility.
contrast
conventional
therapies,
these
approaches
facilitate
precise
targeting
pathogenic
and/or
infectious
microenvironments,
effectively
minimizing
toxicity
mammalian
cells
surrounding
healthy
tissues.
The
highlighted
include
photodynamic
therapy,
photocatalytic
photothermal
endogenous
pigments-based
photobleaching
polyphenols-based
photo-oxidation
therapy.
comprehensive
exploration
aims
offer
updated
information
development
effective,
convenient,
safe,
alternative
counter
growing
MDR
future.
