ROS‐Responsive Core‐Shell Microneedles Based on Simultaneous Efficient Type I/II Photosensitizers for Photodynamic Against Bacterial Biofilm Infections

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract Antimicrobial photodynamic therapy (aPDT) has emerged as an appealing therapeutic option against biofilm infections. However, effectively penetrating the dense barrier of and anchoring bacteria to achieve elimination wound healing under hypoxic environments remains a challenge for aPDT. Herein, three type I/II Hypocrellin B (HB)‐cationic photosensitizers (HB‐P, HB‐TP, HB‐TTP) are designed based on multi‐cationic long chains molecular engineering strategy. With increasing number introduced cations, reactive oxygen species (ROS) production bacterial‐anchoring abilities HB‐cationic greatly enhanced. Notably, HB‐TTP demonstrates higher aPDT activity broad‐spectrum antibacterial properties. Furthermore, address conundrum biofilm‐infected wounds, ROS‐responsive core‐shell microneedle (HB‐TTP&EGF@MN) is by biphasically integrating growth factor. When penetrates biofilm, shell quickly dissolves releases removal laser irradiation. The core subsequently degraded slowly in presence endogenous ROS within wound, facilitating sustained release factor promote tissue regeneration. This work not only provides effective strategy rational design efficient antimicrobial agents but also proposes innovative ideas development controlled‐release pharmaceutical materials synergize

Язык: Английский

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Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Язык: Английский

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3D Film-Like Nanozyme with a Synergistic Amplification Effect for the Ultrasensitive Immunochromatographic Detection of Respiratory Viruses

ACS Nano, Год журнала: 2024, Номер 18(37), С. 25865 - 25879

Опубликована: Сен. 2, 2024

Greatly improving the sensitivity and detection range of lateral flow immunoassays (LFAs) by at least 100 times without using additional instruments remains challenging. Herein, we develop a three-dimensional (3D) film-like nanozyme (GO-Pt

Язык: Английский

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Calcium Hexacyanoferrate Nanozyme Enhances Plant Stress Resistance by Oxidative Stress Alleviation and Heavy Metal Removal

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 10, 2024

Abstract Oxidative damage, exacerbated by the excessive accumulation of reactive oxygen species (ROS), profoundly inhibits both crop growth and yield. Herein, a biocompatible nanozyme, calcium hexacyanoferrate nanoparticles (CaHCF NPs), targeting ROS is developed, to mitigate oxidative damage sequestrate heavy metal ions during plant growth. Uniquely, CaHCF NPs feature multifaced enzyme‐like activities, involving superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase, thiol ascorbate which enable them neutralize ROS. Furthermore, promote calcium‐cadmium exchange process, diminishing uptake metals. Importantly, 120 µg mL −1 alleviate inhibitory effects hydrogen peroxide cadmium chloride on Arabidopsis tomato. The activities SOD, POD, CAT increase 46.2%, 74.4%, 48.3%, respectively, meanwhile level rises 72.4% in under stress. Moreover, boost expression genes associated with antioxidation, detoxification, nutrient transport, stress resistance. These findings unveil significant potential nanoplatforms equipped nanozymes alleviating plants, not only regulate but also substantially ameliorate yield quality, heralding new era agricultural nanotechnology.

Язык: Английский

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Covalent organic framework-immobilized enzymes: A robust engineered catalytic platform for diverse applications

Nano Energy, Год журнала: 2025, Номер unknown, С. 110682 - 110682

Опубликована: Янв. 1, 2025

Язык: Английский

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Cuttlefish‐Inspired Photo‐Responsive Antibacterial Microparticles with Natural Melanin Nanoparticles Spray

Small, Год журнала: 2023, Номер 20(19)

Опубликована: Дек. 5, 2023

Abstract Topical antibiotics can be utilized to treat periodontitis, while their delivery stratagems with controlled release and long‐lasting bactericidal inhibition are yet challenging. Herein, inspired by the defensive behavior of cuttlefish expelling ink, this work develops innovative thermal‐responsive melanin‐integrated porous microparticles (MPs) through microfluidic synthesis for periodontitis treatment. These MPs composed melanin nanoparticles (NPs), poly(N‐isopropylacrylamide) (PNIPAM), agarose. Benefiting from excellent biocompatibility large surface area ratio MPs, they deliver abundant NPs. Under near‐infrared irradiation, NPs convert photo energy into thermal energy. This leads agarose melting subsequent shrinkage microspheres induced pNIPAM, thereby facilitating In addition, released serve as a highly effective photothermal agent, displaying potent antibacterial activity against porphyromonas gingivalis possessing natural anti‐inflammatory properties. unique characteristics further demonstrated in vivo experiments, showing effects treatment infected wounds periodontitis. Therefore, catfish‐inspired photo‐responsive controlled‐release drug hold tremendous potential clinical applications.

Язык: Английский

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Ultralow Loading Copper-Intercalated MoO₃ Nanobelts with High Activity against Antibiotic-Resistant Bacteria

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(14), С. 17182 - 17192

Опубликована: Март 29, 2024

In recent years, the infection rate of antibiotic resistance has been increasing year by year, and prevalence super bacteria posed a great threat to human health. Therefore, there is an urgent need find new alternatives with long-term inhibitory activity against broad spectrum microorganisms in order avoid proliferation more multidrug-resistant (MDR) bacteria. The presence natural van der Waals (vdW) gaps layered materials allows them be easily inserted different guest species, providing attractive strategy for optimizing their physicochemical properties applications. Here, we have successfully constructed copper-intercalated α-MoO3 nanobelt based on nanoenzymes, which antibacterial through synergistic effect multiple enzymes. Compared α-MoO3, MoO3–x/Cu nanobelts copper loading capacity 2.11% possess enhanced peroxidase (POD) catalytic glutathione (GSH) depletion, indicating that intercalation significantly improves performance nanoenzymes. are effective inducing POD oxidase (OXD) catalase (CAT) activities H2O2 O2, resulted generation large amounts reactive oxygen species (ROS), were bacterial killing. Interestingly, can serve as (GSHOx)-like deplete GSH thus improve bactericidal effect. multienzyme-catalyzed antimicrobial shows excellent efficiency β-lactamase-producing Escherichia coli (ESBL-E. coli) methicillin-resistant Staphylococcus aureus (MRSA). exhibits spectral at very low concentrations (20 μg mL–1). Our work highlights wide range anti-infective biological applications catalysts.

Язык: Английский

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Norepinephrine-induced hydrophilic Pd aerogels with photothermal-boosted multienzyme-like activity for chemodynamic therapy of MRSA infections

Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149447 - 149447

Опубликована: Фев. 14, 2024

Язык: Английский

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Artificial Bacteriophages for Treating Oral Infectious Disease via Localized Bacterial Capture and Enhanced Catalytic Sterilization

Advanced Science, Год журнала: 2024, Номер 11(41)

Опубликована: Авг. 19, 2024

Abstract With the rapid emergence of antibiotic‐resistant pathogens, nanomaterial‐assisted catalytic sterilization has been well developed to combat pathogenic bacteria by elevating level reactive oxygen species including hydroxyl radical (·OH). Although promising, ultra‐short lifetime and limited diffusion distance ·OH severely limit their practical antibacterial usage. Herein, rational design preparation novel virus‐like copper silicate hollow spheres (CSHSs) are reported, as applications robust artificial bacteriophages for localized bacterial capture enhanced in treatment oral infectious diseases. During whole process killing, CSHSs can efficiently via shortening between CSHSs, produce massive around bacteria, further iinducing admirable effect inhibition. By using mucosal infection periodontitis typical diseases, it is easily found that populations lesions animals after fall sharply, well‐developed nanosystem decrease inflammatory reaction promote hard or soft tissue repair. Together, high Fenton‐like activity, strong affinity, excellent overall safety nanoplatform promise its great therapeutic potential disinfection.

Язык: Английский

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Microenvironment‐adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm‐associated diabetic chronic wound healing cascade

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Авг. 8, 2024

Abstract The presence of bacterial biofilms and the occurrence excessive inflammatory response greatly imped healing process chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues are still lacking. Here, a microenvironment‐adaptive nanodecoy (GC@Pd) is constructed via coordination situ reduction palladium ions on gallic acid‐modified chitosan (GC) promote wound by synergistic biofilm eradication, inflammation alleviation, immunoregulation. During weakly acidic conditions infection stage, GC@Pd serves as induce aggregation. Subsequently, through its oxidase‐like activity generating reactive oxygen species hyperthermia from photothermal effects, it effectively eliminates biofilm. As local microenvironment transitions an alkaline state, enzyme‐like adapts catalase‐like activity, eliminating at site inflammation. Additionally, could selectively capture pro‐inflammatory cytokines Michael addition reactions. In vivo experiments transcriptomic analysis confirmed that accelerate transition proliferative phase reducing response, thus promoting healing. provides potential therapeutic strategy for treating biofilm‐infected wounds.

Язык: Английский

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