Journal of the American Society for Mass Spectrometry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Untargeted
metabolomics
often
produce
large
datasets
with
missing
values.
These
values
are
derived
from
biological
or
technical
factors
and
can
undermine
statistical
analyses
lead
to
biased
interpretations.
Imputation
methods,
such
as
k-Nearest
Neighbors
(kNN)
Random
Forest
(RF)
regression,
commonly
used,
but
their
effects
vary
depending
on
the
type
of
data,
e.g.,
Missing
Completely
At
(MCAR)
Not
(MNAR).
Here,
we
determined
impacts
degree
data
accuracy
kNN
RF
imputation
using
two
datasets:
a
targeted
metabolomic
dataset
spiked-in
standards
an
untargeted
dataset.
We
also
assessed
effect
compositional
approaches
(CoDA),
centered
log-ratio
(CLR)
transform,
interpretation
since
these
methods
increasingly
being
used
in
metabolomics.
Overall,
found
that
performed
more
accurately
when
proportion
across
samples
for
metabolic
feature
was
low.
However,
imputations
could
not
handle
MNAR
generated
wildly
inflated
imputed
where
none
should
exist.
Furthermore,
show
had
strong
impact
imputation,
which
affected
results.
Our
results
suggest
be
extreme
caution
even
modest
levels
especially
missingness
is
unknown.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 11, 2024
Abstract
Diet,
serving
as
a
vital
source
of
nutrients,
exerts
profound
influence
on
human
health
and
disease
progression.
Recently,
dietary
interventions
have
emerged
promising
adjunctive
treatment
strategies
not
only
for
cancer
but
also
neurodegenerative
diseases,
autoimmune
cardiovascular
metabolic
disorders.
These
demonstrated
substantial
potential
in
modulating
metabolism,
trajectory,
therapeutic
responses.
Metabolic
reprogramming
is
hallmark
malignant
progression,
deeper
understanding
this
phenomenon
tumors
its
effects
immune
regulation
significant
challenge
that
impedes
eradication.
Dietary
intake,
key
environmental
factor,
can
tumor
metabolism.
Emerging
evidence
indicates
might
affect
the
nutrient
availability
tumors,
thereby
increasing
efficacy
treatments.
However,
intricate
interplay
between
pathogenesis
other
diseases
complex.
Despite
encouraging
results,
mechanisms
underlying
diet-based
remain
largely
unexplored,
often
resulting
underutilization
management.
In
review,
we
aim
to
illuminate
various
interventions,
including
calorie
restriction,
fasting-mimicking
diet,
ketogenic
protein
restriction
high-salt
high-fat
high-fiber
aforementioned
diseases.
We
explore
multifaceted
impacts
these
encompassing
their
immunomodulatory
effects,
biological
impacts,
molecular
mechanisms.
This
review
offers
valuable
insights
into
application
therapies
Nutrients,
Год журнала:
2024,
Номер
16(3), С. 412 - 412
Опубликована: Янв. 31, 2024
Alzheimer’s
disease
(AD),
the
most
prevalent
form
of
dementia,
is
characterized
by
accumulation
amyloid-beta
(Aβ)
plaques
and
hyperphosphorylated
tau
tangles.
Currently,
(AD)
impacts
50
million
individuals,
with
projections
anticipating
an
increase
to
152
year
2050.
Despite
increasing
global
prevalence
AD,
its
underlying
pathology
remains
poorly
understood,
posing
challenges
for
early
diagnosis
treatment.
Recent
research
suggests
a
link
between
gut
dysbiosis
aggregation
Aβ,
development
proteins,
occurrence
neuroinflammation
oxidative
stress
are
associated
AD.
However,
investigations
into
gut–brain
axis
(GBA)
in
context
AD
progression
have
yielded
inconsistent
findings.
This
review
aims
enhance
our
understanding
microbial
diversity
at
species
level
role
these
pathology.
Additionally,
this
addresses
influence
confounding
elements,
including
diet,
probiotics,
prebiotics,
on
throughout
different
stages
(preclinical,
mild
cognitive
impairment
(MCI),
AD)
progression.
Nutrients,
Год журнала:
2024,
Номер
16(6), С. 789 - 789
Опубликована: Март 10, 2024
Recent
research
exploring
the
relationship
between
gut
and
brain
suggests
that
condition
of
microbiota
can
influence
cognitive
health.
A
well-balanced
may
help
reduce
inflammation,
which
is
linked
to
neurodegenerative
conditions.
Prebiotics,
probiotics,
symbiotics
are
nutritional
supplements
functional
food
components
associated
with
gastrointestinal
well-being.
The
bidirectional
communication
gut–brain
axis
essential
for
maintaining
homeostasis,
pre-,
pro-,
potentially
affecting
various
functions
such
as
attention,
perception,
memory.
Numerous
studies
have
consistently
shown
incorporating
into
a
healthy
diet
lead
improvements
in
mood.
Maintaining
support
optimal
function,
crucial
disease
prevention
our
fast-paced,
Westernized
society.
Our
results
indicate
benefits
older
individuals
probiotic
supplementation
but
not
who
good
adequate
levels
physical
activity.
Additionally,
it
appears
there
patients
mild
impairment
Alzheimer’s
disease,
while
mixed
seem
arise
younger
healthier
individuals.
However,
important
acknowledge
individual
responses
vary,
use
these
dietary
should
be
tailored
each
individual’s
unique
health
circumstances
needs.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 11, 2025
Polycystic
ovary
syndrome
(PCOS)
is
a
multifaceted
endocrine
disorder
characterized
by
irregularities
in
gonadotropin
secretion,
hyperandrogenism,
chronic
anovulation,
and
polycystic
ovarian
morphology.
In
addition,
it
often
associated
with
metabolic
dysfunctions,
most
notably
insulin
resistance
(IR).
This
affects
approximately
6–20%
of
individuals,
primarily
emerging
during
early
adolescence,
considerably
increases
the
risk
conditions
such
as
impaired
glucose
tolerance,
type
2
diabetes,
endometrial
cancer,
cardiovascular
diseases,
dyslipidemia,
postpartum
complications.
To
date,
there
no
standardized
protocol
for
treating
PCOS.
Existing
therapies
rely
on
personalized
pharmacotherapy
lifestyle
modifications.
However,
these
treatments
may
lead
to
adverse
effects,
medications
prescribed
PCOS
are
used
off-label
have
not
secured
approval
from
U.S.
Food
Drug
Administration
specifically
this
condition.
Recently,
natural
compounds
garnered
considerable
attention
due
their
efficacy
hormone
modulation
minimal
toxicity.
Substances
myo-inositol,
resveratrol,
berberine,
quercetin
shown
promise
mitigating
symptoms.
Their
multi-target
properties
offer
potential
achieve
outcomes
unattainable
single-target
pharmaceuticals,
particularly
managing
heterogeneous
conditions.
review
aims
comprehensively
analyze
vivo
vitro
research
alongside
clinical
interventions
evaluate
influence
prevalence
therapeutic
potential.
These
investigations
lay
groundwork
developing
innovative
strategies
Frontiers in Nutrition,
Год журнала:
2023,
Номер
10
Опубликована: Июнь 29, 2023
Dementia
is
a
growing
public
health
concern,
with
an
estimated
prevalence
of
57
million
adults
worldwide.
Alzheimer’s
disease
(AD)
accounts
for
60–80%
the
cases.
Clinical
trials
testing
potential
drugs
and
neuroprotective
agents
have
proven
futile,
currently
approved
only
provide
symptomatic
benefits.
Emerging
epidemiological
clinical
studies
suggest
that
lifestyle
changes,
including
diet
physical
activity,
offer
alternative
therapeutic
route
slowing
preventing
cognitive
decline
dementia.
Age
single
most
common
risk
factor
dementia,
it
associated
cellular
bioenergetics
metabolic
processes.
Therefore,
nutrient-rich
critical
optimal
brain
health.
Furthermore,
type
2
diabetes
(T2D)
AD,
diets
reduce
T2D
may
confer
neuroprotection.
Foods
predominant
in
Mediterranean,
MIND,
DASH
diets,
fruits,
leafy
green
vegetables,
fish,
nuts,
olive
oil,
prevent
or
slow
decline.
The
mechanisms
by
which
these
nutrients
promote
health,
however,
are
not
yet
completely
understood.
Other
dietary
approaches
eating
regimes,
ketogenic
intermittent
fasting,
also
emerging
as
beneficial
This
review
summarizes
pathophysiology,
factors,
pathways
activated
several
regimes
shown
promising
results
promoting
Nutrients,
Год журнала:
2023,
Номер
15(14), С. 3120 - 3120
Опубликована: Июль 12, 2023
The
ketogenic
diet
(KD)
is,
nowadays,
considered
an
interesting
nutritional
approach
for
weight
loss
and
improvement
in
insulin
resistance.
Nevertheless,
most
of
the
studies
available
literature
do
not
allow
a
clear
distinction
between
its
effects
on
sensitivity
per
se,
induced
by
KDs
sensitivity.
In
this
review,
we
discuss
scientific
evidence
direct
mediated
glycemic
status
humans,
describing
KD's
biochemical
background
underlying
mechanisms.
Abstract
Previous
studies
have
shown
a
bidirectional
communication
between
human
gut
microbiota
and
the
brain,
known
as
microbiota–gut–brain
axis
(MGBA).
The
MGBA
influences
host's
nervous
system
development,
emotional
regulation,
cognitive
function
through
neurotransmitters,
immune
modulation,
metabolic
pathways.
Factors
like
diet,
lifestyle,
genetics,
environment
shape
composition
together.
Most
research
explored
how
regulates
host
physiology
its
potential
in
preventing
treating
neurological
disorders.
However,
individual
heterogeneity
of
microbiota,
strains
playing
dominant
role
diseases,
interactions
these
microbial
metabolites
with
central/peripheral
systems
still
need
exploration.
This
review
summarizes
driving
neurodevelopmental
disorders
(autism
spectrum
disorder
attention
deficit/hyperactivity
disorder),
neurodegenerative
diseases
(Alzheimer's
Parkinson's
disease),
mood
(anxiety
depression)
recent
years
discusses
current
clinical
preclinical
microbe‐based
interventions,
including
dietary
intervention,
probiotics,
prebiotics,
fecal
transplantation.
It
also
puts
forward
insufficient
on
provides
framework
for
further
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3694 - 3694
Опубликована: Март 26, 2024
Metabolic-associated
fatty
liver
disease
(MAFLD)
includes
several
metabolic
dysfunctions
caused
by
dysregulation
in
the
brain–gut–liver
axis
and,
consequently,
increases
cardiovascular
risks
and
dysfunction.
In
MAFLD,
type
2
diabetes
mellitus,
obesity,
syndrome
are
frequently
present;
these
conditions
related
to
lipogenesis
systemic
inflammation.
This
study
aimed
review
connection
between
MAFLD.
The
inflammatory
process,
cellular
alterations
hepatocytes
stellate
cells,
hypercaloric
diet,
sedentarism
aggravate
prognosis
of
patients
with
Thus,
understand
modulation
physiopathology
it
is
necessary
include
organokines
involved
this
process
(adipokines,
myokines,
osteokines,
hepatokines)
their
clinical
relevance
project
future
perspectives
condition
bring
light
new
possibilities
therapeutic
approaches.
Adipokines
responsible
for
activation
distinct
signaling
different
tissues,
such
as
insulin
pro-inflammatory
cytokines,
which
important
balancing
substances
avoid
MAFLD
its
progression.
Myokines
improve
quantity
quality
adipose
contributing
avoiding
development
Finally,
hepatokines
decisive
improving
or
not
progression
through
regulation
anti-inflammatory
organokines.
