Recent advances in MOF-based nanozymes: Synthesis, activities, and bioapplications

Biosensors and Bioelectronics, Год журнала: 2024, Номер 263, С. 116593 - 116593

Опубликована: Июль 18, 2024

Язык: Английский

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Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing

Small, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Abstract Diabetic wounds tend to develop into nonhealing associated with the complex inflammatory microenvironment of uncontrollable bacterial infection, reactive oxygen species (ROS) accumulation, and chronic hypoxia. Damaged blood vessels hinder metabolic circulation, aggravating hypoxia, ROS accumulation further exacerbating diabetic wound microenvironment. However, existing treatments a single functionality have difficulty healing complicated wounds. Therefore, developing an integrative strategy improve hostility is urgently needed. Herein, multifunctional genipin (GP)‐crosslinked chitosan (CS)‐based hydrogels decorated biomimetic metal–organic framework (MOF)‐nanozymes natural antibacterial agent chlorogenic acid (CGA), which named MOF/CGA@GP‐CS (MCGC), are prepared. With catalase (CAT)‐like activity, these dual‐metal MOF‐nanozymes promising bioreactors for simultaneously alleviating hypoxia by converting elevated endogenous H 2 O dissolved in In addition, other component polyphenolic CGA acts as mild agent, efficiently inhibiting infection avoiding antibiotic resistance. Impressively, MCGC accelerate infected eliminating oxidative stress, increasing oxygenation, reversing vivo. this work, effective based on hydrogel dressings successfully developed applied management.

Язык: Английский

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Engineering metal-organic frameworks-based nanozymes for enhanced biomimetic catalytic sensing

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 178, С. 117862 - 117862

Опубликована: Июль 10, 2024

Язык: Английский

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Recent Progress and Prospect of Metal–Organic Framework-Based Nanozymes in Biomedical Application

Nanomaterials, Год журнала: 2024, Номер 14(3), С. 244 - 244

Опубликована: Янв. 23, 2024

A nanozyme is a nanoscale material having enzyme-like properties. It exhibits several superior properties, including low preparation cost, robust catalytic activity, and long-term storage at ambient temperatures. Moreover, high stability enables repetitive use in multiple reactions. Hence, it considered potential replacement for natural enzymes. Enormous research interest nanozymes the past two decades has made imperative to look better enzyme-mimicking materials biomedical applications. Given this, on metal–organic frameworks (MOFs) as gained momentum. MOFs are advanced hybrid of inorganic metal ions organic ligands. Their distinct composition, adaptable pore size, structural diversity, ease tunability physicochemical properties enable mimic activities act promising candidates. This review aims discuss recent advances development MOF-based (MOF-NZs) highlight their applications field biomedicine. Firstly, different enzyme-mimetic exhibited by discussed, insights given into various strategies achieve them. Modification functionalization deliberated obtain MOF-NZs with enhanced activity. Subsequently, biosensing therapeutics domain discussed. Finally, concluded giving challenges encountered possible directions overcome them future. With this review, we aim encourage consolidated efforts across enzyme engineering, nanotechnology, science, biomedicine disciplines inspire exciting innovations emerging yet field.

Язык: Английский

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Nanozymes for regulation of reactive oxygen species and disease therapy

Chinese Chemical Letters, Год журнала: 2021, Номер 32(9), С. 2715 - 2728

Опубликована: Март 18, 2021

Язык: Английский

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