Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 30 - 45
Опубликована: Ноя. 7, 2023
Cancer
remains
a
significant
global
health
concern,
necessitating
the
development
of
innovative
therapeutic
strategies.
This
research
paper
aims
to
investigate
role
pyroptosis
induction
in
cancer
treatment.
Pyroptosis,
form
programmed
cell
death
characterized
by
release
pro-inflammatory
cytokines
and
formation
plasma
membrane
pores,
has
gained
attention
as
potential
target
for
therapy.
The
objective
this
study
is
provide
comprehensive
overview
current
understanding
its
discusses
concept
relationship
with
other
forms
death,
such
apoptosis
necroptosis.
It
explores
immune
activation
combination
also
reviews
use
natural,
biological,
chemical,
multifunctional
composite
materials
cells.
molecular
mechanisms
underlying
these
are
discussed,
along
their
advantages
challenges
findings
highlight
novel
strategy
treatment
insights
into
different
involved
induction.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 3, 2024
Abstract
Zinc
metabolism
at
the
cellular
level
is
critical
for
many
biological
processes
in
body.
A
key
observation
disruption
of
homeostasis,
often
coinciding
with
disease
progression.
As
an
essential
factor
maintaining
equilibrium,
zinc
has
been
increasingly
spotlighted
context
development.
Extensive
research
suggests
zinc’s
involvement
promoting
malignancy
and
invasion
cancer
cells,
despite
its
low
tissue
concentration.
This
led
to
a
growing
body
literature
investigating
metabolism,
particularly
functions
transporters
storage
mechanisms
during
transportation
under
control
two
major
transporter
families:
SLC30
(ZnT)
excretion
SLC39
(ZIP)
intake.
Additionally,
this
element
predominantly
mediated
by
metallothioneins
(MTs).
review
consolidates
knowledge
on
signaling
underscores
potential
molecular
pathways
linking
progression,
special
focus
cancer.
We
also
compile
summary
clinical
trials
involving
ions.
Given
main
localization
cell
membrane,
targeted
therapies,
including
small
molecules
monoclonal
antibodies,
offers
promising
avenues
future
exploration.
Chemical Reviews,
Год журнала:
2023,
Номер
123(18), С. 10920 - 10989
Опубликована: Сен. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(30), С. 16658 - 16668
Опубликована: Июль 24, 2023
Pyroptosis
is
an
inflammatory
form
of
programmed
cell
death
that
holds
great
promise
in
cancer
therapy.
However,
autophagy
as
the
crucial
pyroptosis
checkpoint
and
self-protective
mechanism
cells
significantly
weakens
therapeutic
efficiency.
Here,
a
bioorthogonal
nanoregulator
constructed
to
induce
disrupt
checkpoint,
enabling
high-efficiency
The
allows
situ
synthesis
accumulation
photosensitizer
PpIX
mitochondria
directly
produce
mitochondrial
ROS,
thus
triggering
pyroptosis.
Meanwhile,
generated
inhibitor
via
palladium-catalyzed
chemistry
can
boost
efficacy.
With
biomimetic
membrane
coating,
this
platform
for
modulating
presents
specificity
poses
no
harm
normal
tissue,
resulting
highly
efficient
safe
antitumor
treatment.
To
our
knowledge,
first
report
on
disrupting
intrinsic
protective
tumor
This
work
highlights
plays
key
regulative
role
therapy,
which
would
motivate
future
design
regimens.
Despite
the
great
success
achieved
by
photoactivated
chemotherapy,
eradicating
deep
tumors
using
external
sources
with
high
tissue
penetration
depth
remains
a
challenge.
Here,
we
present
cyaninplatin,
paradigm
of
Pt(IV)
anticancer
prodrug
that
can
be
activated
ultrasound
in
precise
and
spatiotemporally
controllable
manner.
Upon
sono-activation,
mitochondria-accumulated
cyaninplatin
exhibits
strengthened
mitochondrial
DNA
damage
cell
killing
efficiency,
overcomes
drug
resistance
as
consequence
combined
effects
from
released
Pt(II)
chemotherapeutics,
depletion
intracellular
reductants,
burst
reactive
oxygen
species,
which
gives
rise
to
therapeutic
approach,
namely
sono-sensitized
chemotherapy
(SSCT).
Guided
high-resolution
ultrasound,
optical,
photoacoustic
imaging
modalities,
realizes
overall
theranostics
vivo
superior
efficacy
biosafety.
This
work
highlights
practical
utility
precisely
activate
prodrugs
for
eradication
tumor
lesions
broadens
biomedical
uses
Pt
coordination
complexes.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Biometallic
ions
play
a
crucial
role
in
regulating
the
immune
system.
In
recent
years,
cancer
immunotherapy
has
become
breakthrough
treatment,
achieving
good
efficacy
wide
range
of
cancers
with
its
specificity
and
durability
advantages.
However,
existing
therapies
still
face
challenges,
such
as
tolerance
escape.
(e.g.
zinc,
copper,
magnesium,
manganese,
etc.)
can
assist
enhancing
through
activation
cells,
enhancement
tumor
antigen
presentation,
improvement
microenvironment.
addition,
biometallic
derivatives
directly
inhibit
cell
progression
offer
possibility
effectively
overcoming
limitations
current
by
promoting
responses
reducing
immunosuppressive
signals.
This
review
explores
potential
application
prospects
immunotherapy,
providing
new
ideas
for
future
clinical
metal
part
helping
to
guide
development
more
effective
safe
therapeutic
regimens.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(10)
Опубликована: Янв. 3, 2024
Abstract
Platinum
complexes
are
potential
antitumor
drugs
in
chemotherapy.
Their
impact
on
tumor
treatment
could
be
greatly
strengthened
by
combining
with
immunotherapy.
Increasing
evidences
indicate
that
the
activity
of
platinum
is
not
limited
to
chemical
killing
effects,
but
also
extends
immunomodulatory
actions.
This
review
introduced
general
concept
chemoimmunotherapy
and
summarized
progress
as
chemoimmunotherapeutic
agents
recent
years.
developed
into
inducers
immunogenic
cell
death,
blockers
immune
checkpoint,
regulators
signaling
pathway,
modulators
microenvironment,
etc.
The
synergy
between
chemotherapeutic
effects
reinforces
complexes,
helps
them
circumvent
drug
resistance
systemic
toxicity.
exploration
for
may
create
new
opportunities
revive
discovery
metal
anticancer
drugs.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(3), С. 2031 - 2048
Опубликована: Янв. 17, 2024
Metastasis
is
the
major
obstacle
to
survival
of
cancer
patients.
Herein,
a
series
new
desloratadine
platinum(IV)
conjugates
with
promising
antiproliferative
and
antimetastatic
activities
were
developed
evaluated.
The
candidate
complex
caused
significant
DNA
damage
stimulated
mitochondrial
apoptosis
through
Bcl-2/Bax/caspase3
pathway.
Then,
it
suppressed
epithelial–mesenchymal
transition
(EMT)
process
in
tumors
effectively
NMT-1/HPCAL1
β-catenin
signaling.
Subsequently,
angiogenesis
was
inhibited
downregulation
key
proteins
HIF-1α,
VEGFA,
MMP-9,
CD34.
Moreover,
antitumor
immunity
aroused
by
synergism
EMT
reversion
decrease
histamine
level;
then,
macrophage
polarization
from
M2-
M1-type
increase
CD4+
CD8+
T
cells
triggered
simultaneously
tumors.
