Acta Biomaterialia, Год журнала: 2024, Номер 186, С. 454 - 469
Опубликована: Авг. 3, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Abstract In the face of escalating antibiotic resistance crisis, world is embroiled in a silent “antibacterial war”. Scientists are actively searching for innovative antibacterial materials that can be used as effective weapons against bacterial infections. As promising new crystalline porous polymer materials, covalent organic frameworks (COFs) gradually revealing their vast potential applications. This study investigates classification COF‐based agents, provides comprehensive overview applications and research advancements, explores strategies employed by COF materials. Furthermore, challenges outlined lie ahead future application agents insights into prospects within field offered. Through these efforts, aim to accelerate advancements COFs manufacturing technology, promote innovation applications, contribute public health.
Язык: Английский
Процитировано
5
ACS Nano, Год журнала: 2025, Номер 19(5), С. 5253 - 5268
Опубликована: Янв. 31, 2025
Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated characterized via mannose (Man) modification. NPs exhibit significant inhibitory activity against extra- MRSA obviously decrease minimum concentration Van. can be easily internalized by MRSA-infected macrophages significantly accumulated in infected bone Man-mediated targeting. In vivo experiments mouse OM model verified that reduce burden, improve gait patterns, mass, inflammatory cytokine expression. The antibacterial mechanism includes destruction membrane, degeneration proteins DNA, inhibition glycolysis, intervention energy metabolism bacteria. Overall, this metal-antibiotic nanotherapeutics strategy provides new insight for combating infections caused MRSA-induced OM.
Язык: Английский
Процитировано
3
ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 1085 - 1111
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
3
Journal of Materials Science, Год журнала: 2023, Номер 58(19), С. 7839 - 7867
Опубликована: Май 1, 2023
Язык: Английский
Процитировано
38
Small, Год журнала: 2023, Номер 19(52)
Опубликована: Авг. 27, 2023
Abstract Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme by generating positive and negative charges materials' surfaces. This article comprehensively reviews potential mechanisms practical applications of regulating through effect. The first elucidates how enables nanozymes to exhibit catalytic activity. It is highlighted that produced this directly participate redox reactions, leading conversion materials from an inactive active state. Moreover, field generated can enhance accelerating rates or reducing binding energy between substrates. Practical are explored subsequent section, including water pollutant degradation, bacterial disinfection, biological detection, tumor therapy, which demonstrate versatile potentials applications. review concludes emphasizing need for further research into nanozymes, suggesting expanding scope types exploring new application areas. Furthermore, promising direction synergistic therapy discussed as inspiring avenue future research.
Язык: Английский
Процитировано
32
Small, Год журнала: 2023, Номер 19(50)
Опубликована: Авг. 25, 2023
Abstract Bacterial infection continues to be an increasing global health problem with the most widely accepted treatment paradigms restricted antibiotics. However, overuse and misuse of antibiotics have triggered multidrug resistance bacteria, frustrating therapeutic outcomes, leading higher mortality rates. Even worse, tendency bacteria form biofilms on living nonliving surfaces further increases difficulty in confronting because extracellular matrix can act as a robust barrier prevent penetration resist environmental damage. As result, inability eliminate often leads persistent infection, implant failure, device Therefore, it is paramount importance develop alternative antimicrobial agents while avoiding generation bacterial large‐scale growth resistance. In recent years, nano‐antibacterial materials played vital role antibacterial field their excellent physical chemical properties. This review focuses new physicochemical strategies versatile nanomaterials, especially mechanism types 2D nanomaterials. addition, this advanced provides guidance development direction antibiotic‐free disinfections future.
Язык: Английский
Процитировано
30
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(27)
Опубликована: Май 4, 2023
Biofilm formation is a major threat to industry, the environment and human health. While killing of embedded microbes in biofilms may inevitably lead evolution antimicrobial resistance (AMR), catalytic quenching bacterial communications by lactonase promising antifouling approach. Given shortcomings protein enzymes, it attractive engineer synthetic materials mimic activity lactonase. Herein, an efficient lactonase-like Zn-Nx -C nanomaterial was synthesized tuning coordination around zinc atoms active domain for catalytical interception biofilm formation. The material could selectively catalyze 77.5 % hydrolysis N-acylated-L-homoserine lactone (AHL), critical quorum sensing (QS) signal construction. Consequently, AHL degradation downregulated expression QS-related genes antibiotic resistant bacteria significantly prevented As proof concept, -C-coated iron plates 80.3 biofouling after month exposure river. Overall, our study provides nano-enabled contactless insight avoid AMR engineering nanomaterials mimicking key enzymes (e.g., lactonase) functioning
Язык: Английский
Процитировано
25
Coordination Chemistry Reviews, Год журнала: 2023, Номер 496, С. 215431 - 215431
Опубликована: Сен. 4, 2023
Язык: Английский
Процитировано
25
Nano Letters, Год журнала: 2024, Номер 24(13), С. 4044 - 4053
Опубликована: Март 22, 2024
Fungal keratitis (FK) is an infectious eye disease that poses a significant risk of blindness. However, the effectiveness conventional antifungal drugs limited due to intrinsic ocular barrier impedes drug absorption. There urgent need develop new therapeutic strategies effectively combat FK. Herein, we synthesized ultrasmall positively charged carbon dot using simple stage-melting method. The can penetrate corneal by opening tight junctions, allowing them reach lesion site and kill fungi. results both in vitro vivo demonstrated it exhibited good biocompatibility activity, significantly improving effect mouse model Therefore, this biophilic size positive dot, characterized its ability properties, may offer valuable insights into design effective nanomedicines.
Язык: Английский
Процитировано
18
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 20, 2024
Abstract This study explores the coating of photocatalytic nanoparticles with antimicrobial peptides (AMPs) for boosted effects, and how such effects depend on AMP properties. For this, TiO 2 are coated KYE21 or its hydrophobically enhanced variant WWWKYE21. Mirroring free peptides, displayed higher binding UV‐induced degradation bacteria‐like than mammalian‐like membranes. In addition, they degraded bacterial lipopolysaccharides (LPS). WWWKYE21‐coated to LPS membranes degradation, although saturation found at high nanoparticle binding. Neutron reflectometry showed that peptide‐coated resulted in partial lipid removal absence UV, but UV illumination caused additional featuring increases hydration headgroup acyl chain regions. LPS, induced outer O‐antigen region. Analogous findings model systems, against Escherichia coli bacteria pronounced, while toxicity human monocytes remained low. Altogether, results show boosts without causing cell toxicity. From a broader perspective, points potential nanoarchitectonic combination component properties design composite NP
Язык: Английский
Процитировано
15