Enhanced antibacterial and antibiofilm activities of quaternized ultra-high deacetylated chitosan against multidrug-resistant bacteria

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140052 - 140052

Published: Jan. 1, 2025

Language: Английский

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Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant Staphylococcus aureus-Induced Osteomyelitis

ACS Nano, Journal Year: 2025, Volume and Issue: 19(5), P. 5253 - 5268

Published: Jan. 31, 2025

Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated characterized via mannose (Man) modification. NPs exhibit significant inhibitory activity against extra- MRSA obviously decrease minimum concentration Van. can be easily internalized by MRSA-infected macrophages significantly accumulated in infected bone Man-mediated targeting. In vivo experiments mouse OM model verified that reduce burden, improve gait patterns, mass, inflammatory cytokine expression. The antibacterial mechanism includes destruction membrane, degeneration proteins DNA, inhibition glycolysis, intervention energy metabolism bacteria. Overall, this metal-antibiotic nanotherapeutics strategy provides new insight for combating infections caused MRSA-induced OM.

Language: Английский

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Recent advances and mechanism of antimicrobial efficacy of graphene-based materials: a review

Journal of Materials Science, Journal Year: 2023, Volume and Issue: 58(19), P. 7839 - 7867

Published: May 1, 2023

Language: Английский

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Nanomaterials‐Enabled Physicochemical Antibacterial Therapeutics: Toward the Antibiotic‐Free Disinfections

Small, Journal Year: 2023, Volume and Issue: 19(50)

Published: Aug. 25, 2023

Abstract Bacterial infection continues to be an increasing global health problem with the most widely accepted treatment paradigms restricted antibiotics. However, overuse and misuse of antibiotics have triggered multidrug resistance bacteria, frustrating therapeutic outcomes, leading higher mortality rates. Even worse, tendency bacteria form biofilms on living nonliving surfaces further increases difficulty in confronting because extracellular matrix can act as a robust barrier prevent penetration resist environmental damage. As result, inability eliminate often leads persistent infection, implant failure, device Therefore, it is paramount importance develop alternative antimicrobial agents while avoiding generation bacterial large‐scale growth resistance. In recent years, nano‐antibacterial materials played vital role antibacterial field their excellent physical chemical properties. This review focuses new physicochemical strategies versatile nanomaterials, especially mechanism types 2D nanomaterials. addition, this advanced provides guidance development direction antibiotic‐free disinfections future.

Language: Английский

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Piezoelectric Effect Modulates Nanozyme Activity: Underlying Mechanism and Practical Application

Small, Journal Year: 2023, Volume and Issue: 19(52)

Published: Aug. 27, 2023

Abstract Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme by generating positive and negative charges materials' surfaces. This article comprehensively reviews potential mechanisms practical applications of regulating through effect. The first elucidates how enables nanozymes to exhibit catalytic activity. It is highlighted that produced this directly participate redox reactions, leading conversion materials from an inactive active state. Moreover, field generated can enhance accelerating rates or reducing binding energy between substrates. Practical are explored subsequent section, including water pollutant degradation, bacterial disinfection, biological detection, tumor therapy, which demonstrate versatile potentials applications. review concludes emphasizing need for further research into nanozymes, suggesting expanding scope types exploring new application areas. Furthermore, promising direction synergistic therapy discussed as inspiring avenue future research.

Language: Английский

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Nano‐enabled Quenching of Bacterial Communications for the Prevention of Biofilm Formation

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(27)

Published: May 4, 2023

Biofilm formation is a major threat to industry, the environment and human health. While killing of embedded microbes in biofilms may inevitably lead evolution antimicrobial resistance (AMR), catalytic quenching bacterial communications by lactonase promising antifouling approach. Given shortcomings protein enzymes, it attractive engineer synthetic materials mimic activity lactonase. Herein, an efficient lactonase-like Zn-Nx -C nanomaterial was synthesized tuning coordination around zinc atoms active domain for catalytical interception biofilm formation. The material could selectively catalyze 77.5 % hydrolysis N-acylated-L-homoserine lactone (AHL), critical quorum sensing (QS) signal construction. Consequently, AHL degradation downregulated expression QS-related genes antibiotic resistant bacteria significantly prevented As proof concept, -C-coated iron plates 80.3 biofouling after month exposure river. Overall, our study provides nano-enabled contactless insight avoid AMR engineering nanomaterials mimicking key enzymes (e.g., lactonase) functioning

Language: Английский

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Carbon Dots with Integrated Photothermal Antibacterial and Heat‐Enhanced Antioxidant Properties for Diabetic Wound Healing

Small, Journal Year: 2024, Volume and Issue: 20(45)

Published: July 25, 2024

Abstract Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced inflammation. In this study, carbon dots with synergistic antibacterial antioxidant properties, referred as AA‐CDs, are developed specifically for diabetic wound using straightforward solvothermal method. By utilizing cost‐effective precursors like citric acid ascorbic acid, AA‐CDs engineered possess tailored functions of photothermal sterilization ROS scavenging. The resulting demonstrats broad‐spectrum activity, particularly against multidrug‐resistant strains, along efficient scavenging both in solution within cells. Additionally, exhibits protective effect oxidative stress‐induced damage. Notably, high conversion efficiency (41.18%), displays heat‐enhanced performance, providing not only augmented but also additional protection stress, yielding true “1 + 1 > 2” effect. To facilitate use vivo, incorporated into thermally responsive hydrogel, which evident anti‐inflammatory properties modulating inflammatory factors significantly promots the wounds. This study underscores value integrated platforms highlights potential versatile CDs promising therapeutic agents biomedical applications.

Language: Английский

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Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease

Language: Английский

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Antimicrobial Peptide Coating of TiO₂ Nanoparticles for Boosted Antimicrobial Effects

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Abstract This study explores the coating of photocatalytic nanoparticles with antimicrobial peptides (AMPs) for boosted effects, and how such effects depend on AMP properties. For this, TiO 2 are coated KYE21 or its hydrophobically enhanced variant WWWKYE21. Mirroring free peptides, displayed higher binding UV‐induced degradation bacteria‐like than mammalian‐like membranes. In addition, they degraded bacterial lipopolysaccharides (LPS). WWWKYE21‐coated to LPS membranes degradation, although saturation found at high nanoparticle binding. Neutron reflectometry showed that peptide‐coated resulted in partial lipid removal absence UV, but UV illumination caused additional featuring increases hydration headgroup acyl chain regions. LPS, induced outer O‐antigen region. Analogous findings model systems, against Escherichia coli bacteria pronounced, while toxicity human monocytes remained low. Altogether, results show boosts without causing cell toxicity. From a broader perspective, points potential nanoarchitectonic combination component properties design composite NP

Language: Английский

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A H₂S‐Evolving Alternately‐Catalytic Enzyme Bio‐Heterojunction with Antibacterial and Macrophage‐Reprogramming Activity for All‐Stage Infectious Wound Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 29, 2024

The disorder of the macrophage phenotype and hostile by-product lactate evoked by pathogenic infection in hypoxic deep wound inevitably lead to stagnant skin regeneration. In this study, hydrogen sulfide (H

Language: Английский

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