Advanced Composites and Hybrid Materials, Год журнала: 2023, Номер 6(4)
Опубликована: Июль 19, 2023
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(28)
Опубликована: Авг. 7, 2023
Abstract Cuproptosis, a kind of newly recognized cell death modality, shows enormous prospect in cancer treatment. The inducer cuproptosis has more advantages tumor therapy, especially that can trigger and chemodynamic therapy (CDT) simultaneously. However, is restricted to the deficiency intracellular copper ions nonspecific delivery copper‐based ionophores. Therefore, high level delivery, responsive release, utilizing synergistic‐function become key on cuproptosis‐based oncotherapy. In this work, cascade nanosystem constructed for enhanced CDT. weak acidic environment cells, DNA, zinc ions, Cu + release from nanosystem. Since having superior performance mediating both Fenton‐like reaction cuproptosis, released induces CDT efficiently, accompanied by 2+ generation. Then be converted into partially glutathione (GSH) supply loop ensure synergistic action. Meanwhile, consumption GSH also contributes return. Finally, DNA Zn form DNAzyme shear catalase‐related RNA, resulting accumulation hydrogen peroxide further enhancing combination therapy. These results provide promising nanotherapeutic platform may inspire design potential treatment based cuproptosis.
Язык: Английский
Процитировано
31
Small, Год журнала: 2023, Номер 19(52)
Опубликована: Авг. 27, 2023
Abstract Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme by generating positive and negative charges materials' surfaces. This article comprehensively reviews potential mechanisms practical applications of regulating through effect. The first elucidates how enables nanozymes to exhibit catalytic activity. It is highlighted that produced this directly participate redox reactions, leading conversion materials from an inactive active state. Moreover, field generated can enhance accelerating rates or reducing binding energy between substrates. Practical are explored subsequent section, including water pollutant degradation, bacterial disinfection, biological detection, tumor therapy, which demonstrate versatile potentials applications. review concludes emphasizing need for further research into nanozymes, suggesting expanding scope types exploring new application areas. Furthermore, promising direction synergistic therapy discussed as inspiring avenue future research.
Язык: Английский
Процитировано
27
Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1338 - 1338
Опубликована: Апрель 26, 2023
Electric stimulation has been used in changing the morphology, status, membrane permeability, and life cycle of cells to treat certain diseases such as trauma, degenerative disease, tumor, infection. To minimize side effects invasive electric stimulation, recent studies attempt apply ultrasound control piezoelectric effect nano material. This method not only generates an field but also utilizes benefits non-invasive mechanical effects. In this review, important elements system, piezoelectricity nanomaterial ultrasound, are first analyzed. Then, we summarize categorized into five kinds, nervous system treatment, musculoskeletal tissues cancer anti-bacteria therapy, others, prove two main mechanics under activated piezoelectricity: one is biological change on a cellular level, other piezo-chemical reaction. However, there still technical problems be solved regulation processes completed before widespread use. The core include how accurately measure properties, concisely electricity release through complex energy transfer processes, deeper understanding related bioeffects. If these conquered future, nanomaterials by will provide new pathway realize application disease treatment.
Язык: Английский
Процитировано
24
Small Methods, Год журнала: 2024, Номер unknown
Опубликована: Март 13, 2024
Abstract Cascade reactions are described as efficient and versatile tools, organized catalytic cascades can significantly improve the efficiency of chemical interworking between nanozymes. They have attracted great interest in many fields such chromogenic detection, biosensing, tumor diagnosis, therapy. However, how to selectively kill cells by enzymatic without harming normal cells, well exploring two or more enzyme‐engineered nanoreactors for cascading reactions, remain challenges field targeted specific cancer diagnostics The latest research advances nanozyme‐catalyzed cascade processes diagnosis therapy this article. Here, various sensing strategies summarized, tumor‐specific diagnostics. Targeting mechanisms treatment using nanozymes classified analyzed, “elements” “dimensions” nanozymes, types, designs structure, assembly modes highly active a variety new targeting based on reaction Finally, integrated application systems tumor‐targeted diagnostic is which will lay foundation design rational, efficient, therapeutic modalities future.
Язык: Английский
Процитировано
15
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 130960 - 130960
Опубликована: Март 20, 2024
Tumors remain one of the major threats to public health and there is an urgent need design new pharmaceutical agents for their diagnosis treatment. In recent years, due rapid development nanotechnology, biotechnology, catalytic science, theoretical computing, subtlety has gradually made great progress in research related tumor Compared conventional drugs, enzymes can improve drug distribution enhance enrichment at site, thereby reducing side effects enhancing efficacy. Nanozymes also be used as tracking imaging reshape microenvironment, providing a versatile platform treatment malignancies. this paper, we review current status on oncology analyze novel therapeutic approaches mechanisms. To date, large number nanomaterials, such noble metal nonmetallic carbon-based have been shown able function like natural enzymes, particularly with significant advantages therapy. light this, authors systematically summarized evaluated construction, enzymatic activity, characteristics nanozymes respect modalities addition, application different types nicknames features years are detail. We conclude summary outlook study It hoped that will inspire researchers fields chemistry, biology, materials science contribute nano-enzymology.
Язык: Английский
Процитировано
13
Angewandte Chemie International Edition, Год журнала: 2024, Номер 64(1)
Опубликована: Авг. 22, 2024
Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme-like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near-infrared II bio-window endows remarkable photothermal conversion performance. Consequently, achieves high-efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic
Язык: Английский
Процитировано
12
Biomaterials, Год журнала: 2024, Номер 307, С. 122523 - 122523
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
10
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Март 30, 2024
Язык: Английский
Процитировано
10
Advanced Materials, Год журнала: 2024, Номер 36(45)
Опубликована: Сен. 3, 2024
Abstract Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form inflammatory programmed cell death, presents dependable strategy combating cancer by engaging multiple death pathways (apoptosis, pyroptosis, necroptosis). In this study, ultrasmall Bi 2 Sn O 7 nanozyme with ultrasound‐magnified multienzyme‐mimicking properties designed engineered as PANoptosis inducer through destroying mitochondrial function tumor cells enhancing intracellular accumulation toxic reactive oxygen species, finally triggering activation process. The role has been verified expression related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, 1, p‐MLKL, RIPK3. inclusion external ultrasonic irradiation significantly augments enzyodynamic efficiency. vitro in vivo antineoplastic efficacy, along inhibition lung metastasis, validate benefits ‐mediated pathway. This study not only elucidates intricate mechanisms underlying inducer, but also offers novel perspective treatment carcinoma.
Язык: Английский
Процитировано
10
Advanced Functional Materials, Год журнала: 2024, Номер 34(33)
Опубликована: Май 16, 2024
Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.
Язык: Английский
Процитировано
9