Journal of Hazardous Materials, Год журнала: 2024, Номер 479, С. 135751 - 135751
Опубликована: Сен. 5, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215718 - 215718
Опубликована: Фев. 18, 2024
Язык: Английский
Процитировано
35
Advanced Functional Materials, Год журнала: 2024, Номер 34(36)
Опубликована: Март 29, 2024
Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), emerged a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, remarkable chemical stability, undergone comprehensive investigation extensive exploration within realm of biological theranostics. This work aims to provide summary advancements development design strategies NIR‐II BODIPY fluorophores tailored advanced phototheranostics. Initially, elucidates several representative strategies, concluding electron‐programming strategy, extension conjugated backbone, J‐aggregation strategic establishment activatable fluorophores, which enhance skeletons. Subsequently, developments fluorescent BODIPY‐based nanoplatforms applications are intricately elaborated. In conclusion, this outlines future efforts directions refining meet evolving clinical demands. It is anticipated that contribution may feasible reference thereby advancing their potential practices.
Язык: Английский
Процитировано
27
Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
20
Coordination Chemistry Reviews, Год журнала: 2025, Номер 528, С. 216379 - 216379
Опубликована: Янв. 4, 2025
Язык: Английский
Процитировано
4
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Апрель 25, 2024
Abstract J‐aggregate is a promising strategy to enhance second near‐infrared window (NIR‐II) emission, while the controlled synthesis of J‐aggregated NIR‐II dyes huge challenge because lack molecular design principle. Herein, bulk spiro[fluorene‐9,9′‐xanthene] functionalized benzobisthiadiazole‐based (named BSFX‐BBT and OSFX‐BBT) are synthesized with different alkyl chains. The weak repulsion interaction between donor acceptor units S…N secondary interactions make adopt co‐planar conformation display peak absorption >880 nm in solution. Importantly, can form desiring condensed state, femtosecond transient spectra reveal that excited states radiative states, facilitate stimulated emission. Consequently, nanoparticles (NPs) emission at 1124 high relative quantum yield 0.81%. efficient good photothermal effect, biocompatibility NPs demonstrate antitumor efficacy via fluorescence/photoacoustic imaging‐guided phototherapy. paradigm illustrates tuning aggregate dye spiro‐functionalized an effective approach photo‐theranostic performance.
Язык: Английский
Процитировано
13
Nano Letters, Год журнала: 2024, Номер 24(27), С. 8287 - 8295
Опубликована: Июнь 28, 2024
Organic dyes with simultaneously boosted near-infrared-II (NIR-II) fluorescence, type I photodynamic therapy (PDT), and photothermal (PTT) in the aggregate state are still elusive due to unclear structure-function relationship. Herein, electron-withdrawing substituents introduced at 5-indolyl positions of BODIPY form tight J-aggregates for enhanced NIR-II fluorescence PDT/PTT. The introduction an electron-rich julolidine group
Язык: Английский
Процитировано
12
Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown
Опубликована: Авг. 19, 2024
The development of polymer-based persistent luminescence materials with color-tunable organic afterglow and multiple responses is highly desirable for applications in anti-counterfeiting, flexible displays, data-storage. However, achieving efficient from a single-phosphor system remains challenging task. Herein, by doping 9H-pyrido[3,4-b]indole (PI2) into an amorphous polyacrylamide matrix, hierarchical dual-mode emission developed, which exhibits due to excitation-, temperature-, humidity-dependence. Notably, the coexistence isolated state J-aggregate guest molecule not only provides excitation-dependent color, but also leads temperature-dependent color resulting different thermally activated delayed fluorescence (TADF) ultralong phosphorescence (UOP) behaviors aggregated states. complex responsiveness based on can serve security features through inkjet printing ink-writing. These findings may provide further insight regulated phosphors doped polymer systems expand scope stimuli-responsive broader applications.
Язык: Английский
Процитировано
12
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(34)
Опубликована: Июнь 10, 2024
Abstract J‐aggregation brings intriguing optical and electronic properties to molecular dyes significantly expands their applicability across diverse domains, yet the challenge for rationally designing J‐aggregating persists. Herein, we developed a large number of from scratch by progressively refining structure common heptamethine cyanine. J‐aggregates with sharp spectral bands (full‐width at half‐maximum≤38 nm) are attained introducing branched featuring benzyl trifluoroacetyl group meso‐position dyes. Fine‐tuning enables regulation J‐aggregates. Analysis single crystal data nine reveals correlation between propensity arrangement within crystals. Some successfully implemented in multiplexed optoacoustic fluorescence imaging animals. Notably, three‐color multispectral tomography high spatiotemporal resolution is achieved, owing distinct absorption
Язык: Английский
Процитировано
11
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging efficient therapeutic capabilities. In this work, a supramolecular strategy is employed construct molecular pair agent via the direct self‐assembly two cyanines, C5TNa (anionic) Cy‐Et (cationic). The Coulombic interactions between facilitate formation complementary cyanine (C5T‐ET) creation CT‐J‐type aggregates in water. This results completely quenched fluorescence significantly enhances nonradiative deactivation (≈22 ps), leading 3.3‐fold increase photothermal conversion efficiency 7.1‐fold enhancement response compared indocyanine green (ICG). As result, J‐type aggregate demonstrates high capability remarkable antitumor efficacy vivo, highlighting its potential clinical applications. work provides strong experimental evidence superior performance enhancing photosensitization response. It believed will propel advancement controllable dye J‐aggregates contribute practical implementation phototherapy vivo.
Язык: Английский
Процитировано
1
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Окт. 11, 2024
Abstract Organic agents possessing NIR‐II and photoacoustic duplex imaging capabilities, coupled with high‐efficiency photothermal conversion, offer significant potential for noninvasive precise phototheranostics of glioblastoma, which is further augmented when these can concurrently exhibit tumor targeting blood–brain barrier (BBB) permeability. This study reports a series finely tunable molecular luminophores based on the aza‐BODIPY scaffold, featuring unique twisted rotatable structures. They are constructed to folate‐decorated polymeric nanoparticles, exhibiting remarkable NIR‐II/photoacoustic performance superior conversion efficiency (49.7%). Folate modification enables BBB permeability through receptor‐mediated transcytosis, allowing efficient phototherapy in 4T1‐/glioblastoma‐bearing mice after single intravenous injection irradiation. presents rational engineering approach versatile structural scaffold designing emitters tailored photophysical properties desirable phototherapeutic efficacy, thereby offering novel perspectives development advanced depth probes brain therapeutics.
Язык: Английский
Процитировано
6