Russian Chemical Reviews,
Год журнала:
2024,
Номер
93(10), С. RCR5136 - RCR5136
Опубликована: Окт. 1, 2024
BODIPY
chromophores
(4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)
are
one
of
the
most
versatile
fluorophores
which
commonly
used
in
a
variety
scientific
fields.
The
combination
excellent
photophysical
properties
with
possibility
easy
chemical
modification
structure,
and
photostability
determines
application
biomedicine,
photocatalysis,
analytical
chemistry
materials
science.
This
review
summarizes
approaches
to
synthesis
BODIPY,
discussing
both
classical
recently-published
synthetic
postfunctionalization
approaches.
An
influence
structure
various
methods
on
their
potential
applications
science
biosensorics
also
discussed.<br>
bibliography
includes
344
references.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Март 29, 2024
Abstract
Fluorescence
imaging
in
the
second
near‐infrared
window
(NIR‐II,
1000–1700
nm)
has
aroused
immense
attention
for
biomedical
applications,
offering
exceptional
advantages
such
as
ultra‐low
photon
scattering
and
increased
tissue
penetration.
Among
NIR‐II‐emitted
organic
dyes,
Boron
dipyrromethene
(BODIPY),
emerged
a
noteworthy
candidate.
BODIPY,
distinguished
by
its
controllable
molecular
structure
optical
properties,
outstanding
fluorescence
quantum
yields,
high
molar
absorption
coefficients,
remarkable
chemical
stability,
undergone
comprehensive
investigation
extensive
exploration
within
realm
of
biological
theranostics.
This
work
aims
to
provide
summary
advancements
development
design
strategies
NIR‐II
BODIPY
fluorophores
tailored
advanced
phototheranostics.
Initially,
elucidates
several
representative
strategies,
concluding
electron‐programming
strategy,
extension
conjugated
backbone,
J‐aggregation
strategic
establishment
activatable
fluorophores,
which
enhance
skeletons.
Subsequently,
developments
fluorescent
BODIPY‐based
nanoplatforms
applications
are
intricately
elaborated.
In
conclusion,
this
outlines
future
efforts
directions
refining
meet
evolving
clinical
demands.
It
is
anticipated
that
contribution
may
feasible
reference
thereby
advancing
their
potential
practices.
Nano Letters,
Год журнала:
2024,
Номер
24(27), С. 8287 - 8295
Опубликована: Июнь 28, 2024
Organic
dyes
with
simultaneously
boosted
near-infrared-II
(NIR-II)
fluorescence,
type
I
photodynamic
therapy
(PDT),
and
photothermal
(PTT)
in
the
aggregate
state
are
still
elusive
due
to
unclear
structure-function
relationship.
Herein,
electron-withdrawing
substituents
introduced
at
5-indolyl
positions
of
BODIPY
form
tight
J-aggregates
for
enhanced
NIR-II
fluorescence
PDT/PTT.
The
introduction
an
electron-rich
julolidine
group
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 25, 2024
Abstract
J‐aggregate
is
a
promising
strategy
to
enhance
second
near‐infrared
window
(NIR‐II)
emission,
while
the
controlled
synthesis
of
J‐aggregated
NIR‐II
dyes
huge
challenge
because
lack
molecular
design
principle.
Herein,
bulk
spiro[fluorene‐9,9′‐xanthene]
functionalized
benzobisthiadiazole‐based
(named
BSFX‐BBT
and
OSFX‐BBT)
are
synthesized
with
different
alkyl
chains.
The
weak
repulsion
interaction
between
donor
acceptor
units
S…N
secondary
interactions
make
adopt
co‐planar
conformation
display
peak
absorption
>880
nm
in
solution.
Importantly,
can
form
desiring
condensed
state,
femtosecond
transient
spectra
reveal
that
excited
states
radiative
states,
facilitate
stimulated
emission.
Consequently,
nanoparticles
(NPs)
emission
at
1124
high
relative
quantum
yield
0.81%.
efficient
good
photothermal
effect,
biocompatibility
NPs
demonstrate
antitumor
efficacy
via
fluorescence/photoacoustic
imaging‐guided
phototherapy.
paradigm
illustrates
tuning
aggregate
dye
spiro‐functionalized
an
effective
approach
photo‐theranostic
performance.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 19, 2024
The
development
of
polymer-based
persistent
luminescence
materials
with
color-tunable
organic
afterglow
and
multiple
responses
is
highly
desirable
for
applications
in
anti-counterfeiting,
flexible
displays,
data-storage.
However,
achieving
efficient
from
a
single-phosphor
system
remains
challenging
task.
Herein,
by
doping
9H-pyrido[3,4-b]indole
(PI2)
into
an
amorphous
polyacrylamide
matrix,
hierarchical
dual-mode
emission
developed,
which
exhibits
due
to
excitation-,
temperature-,
humidity-dependence.
Notably,
the
coexistence
isolated
state
J-aggregate
guest
molecule
not
only
provides
excitation-dependent
color,
but
also
leads
temperature-dependent
color
resulting
different
thermally
activated
delayed
fluorescence
(TADF)
ultralong
phosphorescence
(UOP)
behaviors
aggregated
states.
complex
responsiveness
based
on
can
serve
security
features
through
inkjet
printing
ink-writing.
These
findings
may
provide
further
insight
regulated
phosphors
doped
polymer
systems
expand
scope
stimuli-responsive
broader
applications.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(34)
Опубликована: Июнь 10, 2024
Abstract
J‐aggregation
brings
intriguing
optical
and
electronic
properties
to
molecular
dyes
significantly
expands
their
applicability
across
diverse
domains,
yet
the
challenge
for
rationally
designing
J‐aggregating
persists.
Herein,
we
developed
a
large
number
of
from
scratch
by
progressively
refining
structure
common
heptamethine
cyanine.
J‐aggregates
with
sharp
spectral
bands
(full‐width
at
half‐maximum≤38
nm)
are
attained
introducing
branched
featuring
benzyl
trifluoroacetyl
group
meso‐position
dyes.
Fine‐tuning
enables
regulation
J‐aggregates.
Analysis
single
crystal
data
nine
reveals
correlation
between
propensity
arrangement
within
crystals.
Some
successfully
implemented
in
multiplexed
optoacoustic
fluorescence
imaging
animals.
Notably,
three‐color
multispectral
tomography
high
spatiotemporal
resolution
is
achieved,
owing
distinct
absorption
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Molecular
phototheranostic
dyes
are
of
eminent
interest
for
oncological
diagnosis
and
imaging‐guided
phototherapy.
However,
it
remains
challenging
to
develop
photosensitizers
(PSs)
that
simultaneously
integrate
high‐contrast
photoacoustic
imaging
efficient
therapeutic
capabilities.
In
this
work,
a
supramolecular
strategy
is
employed
construct
molecular
pair
agent
via
the
direct
self‐assembly
two
cyanines,
C5TNa
(anionic)
Cy‐Et
(cationic).
The
Coulombic
interactions
between
facilitate
formation
complementary
cyanine
(C5T‐ET)
creation
CT‐J‐type
aggregates
in
water.
This
results
completely
quenched
fluorescence
significantly
enhances
nonradiative
deactivation
(≈22
ps),
leading
3.3‐fold
increase
photothermal
conversion
efficiency
7.1‐fold
enhancement
response
compared
indocyanine
green
(ICG).
As
result,
J‐type
aggregate
demonstrates
high
capability
remarkable
antitumor
efficacy
vivo,
highlighting
its
potential
clinical
applications.
work
provides
strong
experimental
evidence
superior
performance
enhancing
photosensitization
response.
It
believed
will
propel
advancement
controllable
dye
J‐aggregates
contribute
practical
implementation
phototherapy
vivo.
Abstract
Organic
agents
possessing
NIR‐II
and
photoacoustic
duplex
imaging
capabilities,
coupled
with
high‐efficiency
photothermal
conversion,
offer
significant
potential
for
noninvasive
precise
phototheranostics
of
glioblastoma,
which
is
further
augmented
when
these
can
concurrently
exhibit
tumor
targeting
blood–brain
barrier
(BBB)
permeability.
This
study
reports
a
series
finely
tunable
molecular
luminophores
based
on
the
aza‐BODIPY
scaffold,
featuring
unique
twisted
rotatable
structures.
They
are
constructed
to
folate‐decorated
polymeric
nanoparticles,
exhibiting
remarkable
NIR‐II/photoacoustic
performance
superior
conversion
efficiency
(49.7%).
Folate
modification
enables
BBB
permeability
through
receptor‐mediated
transcytosis,
allowing
efficient
phototherapy
in
4T1‐/glioblastoma‐bearing
mice
after
single
intravenous
injection
irradiation.
presents
rational
engineering
approach
versatile
structural
scaffold
designing
emitters
tailored
photophysical
properties
desirable
phototherapeutic
efficacy,
thereby
offering
novel
perspectives
development
advanced
depth
probes
brain
therapeutics.
