Near-infrared boron–dipyrrin (BODIPY) nanomaterials: Molecular design and anti-tumor therapeutics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215718 - 215718

Published: Feb. 18, 2024

Language: Английский

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Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: March 29, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), emerged a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, remarkable chemical stability, undergone comprehensive investigation extensive exploration within realm of biological theranostics. This work aims to provide summary advancements development design strategies NIR‐II BODIPY fluorophores tailored advanced phototheranostics. Initially, elucidates several representative strategies, concluding electron‐programming strategy, extension conjugated backbone, J‐aggregation strategic establishment activatable fluorophores, which enhance skeletons. Subsequently, developments fluorescent BODIPY‐based nanoplatforms applications are intricately elaborated. In conclusion, this outlines future efforts directions refining meet evolving clinical demands. It is anticipated that contribution may feasible reference thereby advancing their potential practices.

Language: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

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Recent advances in near-infrared-II organic J-aggregates for bio-applications

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216379 - 216379

Published: Jan. 4, 2025

Language: Английский

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J‐Aggregate Promoting NIR‐II Emission for Fluorescence/ Photoacoustic Imaging‐Guided Phototherapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Abstract J‐aggregate is a promising strategy to enhance second near‐infrared window (NIR‐II) emission, while the controlled synthesis of J‐aggregated NIR‐II dyes huge challenge because lack molecular design principle. Herein, bulk spiro[fluorene‐9,9′‐xanthene] functionalized benzobisthiadiazole‐based (named BSFX‐BBT and OSFX‐BBT) are synthesized with different alkyl chains. The weak repulsion interaction between donor acceptor units S…N secondary interactions make adopt co‐planar conformation display peak absorption >880 nm in solution. Importantly, can form desiring condensed state, femtosecond transient spectra reveal that excited states radiative states, facilitate stimulated emission. Consequently, nanoparticles (NPs) emission at 1124 high relative quantum yield 0.81%. efficient good photothermal effect, biocompatibility NPs demonstrate antitumor efficacy via fluorescence/photoacoustic imaging‐guided phototherapy. paradigm illustrates tuning aggregate dye spiro‐functionalized an effective approach photo‐theranostic performance.

Language: Английский

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Electron-Withdrawing Substituents Enhance the Type I PDT and NIR-II Fluorescence of BODIPY J Aggregates for Bioimaging and Cancer Therapy

Nano Letters, Journal Year: 2024, Volume and Issue: 24(27), P. 8287 - 8295

Published: June 28, 2024

Organic dyes with simultaneously boosted near-infrared-II (NIR-II) fluorescence, type I photodynamic therapy (PDT), and photothermal (PTT) in the aggregate state are still elusive due to unclear structure-function relationship. Herein, electron-withdrawing substituents introduced at 5-indolyl positions of BODIPY form tight J-aggregates for enhanced NIR-II fluorescence PDT/PTT. The introduction an electron-rich julolidine group

Language: Английский

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Hierarchical Dual‐Mode Efficient Tunable Afterglow via J‐Aggregates in Single‐Phosphor‐Doped Polymer

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

The development of polymer-based persistent luminescence materials with color-tunable organic afterglow and multiple responses is highly desirable for applications in anti-counterfeiting, flexible displays, data-storage. However, achieving efficient from a single-phosphor system remains challenging task. Herein, by doping 9H-pyrido[3,4-b]indole (PI2) into an amorphous polyacrylamide matrix, hierarchical dual-mode emission developed, which exhibits due to excitation-, temperature-, humidity-dependence. Notably, the coexistence isolated state J-aggregate guest molecule not only provides excitation-dependent color, but also leads temperature-dependent color resulting different thermally activated delayed fluorescence (TADF) ultralong phosphorescence (UOP) behaviors aggregated states. complex responsiveness based on can serve security features through inkjet printing ink-writing. These findings may provide further insight regulated phosphors doped polymer systems expand scope stimuli-responsive broader applications.

Language: Английский

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Structurally Modulated Formation of Cyanine J‐aggregates with Sharp and Tunable Spectra for Multiplexed Optoacoustic and Fluorescence Bioimaging

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)

Published: June 10, 2024

Abstract J‐aggregation brings intriguing optical and electronic properties to molecular dyes significantly expands their applicability across diverse domains, yet the challenge for rationally designing J‐aggregating persists. Herein, we developed a large number of from scratch by progressively refining structure common heptamethine cyanine. J‐aggregates with sharp spectral bands (full‐width at half‐maximum≤38 nm) are attained introducing branched featuring benzyl trifluoroacetyl group meso‐position dyes. Fine‐tuning enables regulation J‐aggregates. Analysis single crystal data nine reveals correlation between propensity arrangement within crystals. Some successfully implemented in multiplexed optoacoustic fluorescence imaging animals. Notably, three‐color multispectral tomography high spatiotemporal resolution is achieved, owing distinct absorption

Language: Английский

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Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging efficient therapeutic capabilities. In this work, a supramolecular strategy is employed construct molecular pair agent via the direct self‐assembly two cyanines, C5TNa (anionic) Cy‐Et (cationic). The Coulombic interactions between facilitate formation complementary cyanine (C5T‐ET) creation CT‐J‐type aggregates in water. This results completely quenched fluorescence significantly enhances nonradiative deactivation (≈22 ps), leading 3.3‐fold increase photothermal conversion efficiency 7.1‐fold enhancement response compared indocyanine green (ICG). As result, J‐type aggregate demonstrates high capability remarkable antitumor efficacy vivo, highlighting its potential clinical applications. work provides strong experimental evidence superior performance enhancing photosensitization response. It believed will propel advancement controllable dye J‐aggregates contribute practical implementation phototherapy vivo.

Language: Английский

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Spacer Twisting Strategy to Realize Ultrabright Near-Infrared II Polymer Nanoparticles for Fluorescence Imaging-Guided Tumor Phototheranostics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(41), P. 28178 - 28188

Published: Oct. 3, 2024

Conjugated polymers are becoming popular near-infrared II (NIR-II) phototheranostic agents (PTAs) due to their numerous advantages, such as high photostability, large molar extinction coefficients, and excellent photothermal properties. However, the strong π-π interactions between chains of conjugated resulted in generally low NIR-II emission quantum yields (QY). Therefore, synthesis with QY is an interesting but challenging task. Herein, we proposed a spacer twisting strategy realize ultrabright polymer nanoparticles for fluorescence imaging-guided tumor phototheranostics. Theoretical calculations indicated that PY-IT has largest dihedral angle largely π-conjugated skeleton spacer, which can effectively inhibit intermolecular stacking, resulting improved 16.5% nanoparticles. In addition, NPs perform imaging treatment tumors. The work presents some valuable guides achieving polymeric PTAs QY.

Language: Английский

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