We
present
a
versatile
nickel-electrocatalytic
deaminative
cross-coupling
platform
for
the
efficient
construction
of
C(sp
3
)–C(sp
)
and
2
bonds
from
readily
available
alkyl
bistriflimides.
This
methodology
involves
assembly
two
leaving
groups
on
amines
to
form
bistriflimides,
followed
by
their
effective
coupling
with
wide
range
halides,
pseudohalides,
aryl
alkenyl
halides
under
electrochemical
reductive
conditions.
Moreover,
successful
application
relay
transition
metal–free
cross-electrophile
further
demonstrates
versatility
bistriflimides
as
valuable
building
blocks
in
organic
synthesis.
Combined
control
experiments
density
functional
theory
calculations
provide
insights
into
reaction
pathway
crucial
role
iodide
catalytic
process.
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 2500 - 2566
Опубликована: Окт. 9, 2024
With
the
resurgence
of
electrosynthesis
in
organic
chemistry,
there
is
a
significant
increase
number
routes
available
for
late-stage
functionalization
(LSF)
drugs.
Electrosynthetic
methods,
which
obviate
need
hazardous
chemical
oxidants
or
reductants,
offer
unprecedented
control
reactions
through
continuous
variation
applied
potential
and
possibility
combination
with
photochemical
processes.
This
capability
substantial
advantage
performing
electrochemical
photoelectrochemical
LSF.
Ultimately,
these
protocols
are
poised
to
become
vital
component
medicinal
chemist's
toolkit.
In
this
review,
we
discuss
that
have
been
demonstrated
be
applicable
LSF
pharmaceutical
drugs,
their
derivatives,
natural
substrates.
We
present
analyze
representative
examples
illustrate
electrochemistry
photoelectrochemistry
valuable
molecular
scaffolds.
iScience,
Год журнала:
2025,
Номер
28(3), С. 111976 - 111976
Опубликована: Фев. 10, 2025
1,n-Dual
Π
systems
including
1,4-diene
derivatives
have
been
widely
used
as
the
elegant
radical
receptors
to
promote
cascade
additions
give
highly
functionalized
polycyclic
scaffolds.
However,
tedious
and
complicated
preparation
of
former
deters
broad
utilization
compromises
practical
value.
Herein,
a
straightforward
was
developed
from
easily
accessible
alkynes
γ,δ-unsaturated
carboxylic
acids
via
electrochemical
oxidation
cyclization
Hofmann
elimination.
This
transformation
features
with
good
excellent
yields,
functional
group
compatibility,
selectivity
without
any
Zaitsev
elimination
product
detected.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(14), С. 10004 - 10011
Опубликована: Июнь 27, 2024
-Alkoxyphthalimides,
one
kind
of
phthalimide
derivative,
have
great
importance
in
synthesis,
mainly
used
as
free
radical
precursors.
While
the
unit,
for
a
long
time,
was
treated
part
waste
stream.
Construction
C-N
bonds
has
always
been
hot
spot,
especially
reductive
cross-coupling.
Herein,
nickel-catalyzed
cross-coupling
reaction
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 31, 2024
Palladium-catalyzed
Suzuki–Miyaura
cross-coupling
is
an
efficient
approach
for
C–C
bond
construction.
Here
we
report
a
deaminative
reaction
to
achieve
chemo-
and
regioselectivity
in
the
of
nonactivated
propargylamines
with
boronic
acids,
which
methyl
propiolate
introduced
promote
cleavage
C–N
form
bond.
This
method
features
wide
range
substrates,
good
functional
group
tolerance,
ease
operation,
providing
alternative
accessing
valuable
propargylated
aromatic
compounds.
Molecules,
Год журнала:
2024,
Номер
29(19), С. 4669 - 4669
Опубликована: Окт. 1, 2024
The
synthesis
of
unsymmetrical
diorganyl
selanes
was
accomplished
under
electrochemical
conditions
in
an
undivided
cell
utilizing
a
magnesium
cathode
and
carbon
anode
made
out
aryl
alkyl
iodides
diselanes.
This
cross-electrophile
coupling
(eXEC)
using
simple
nickel
catalyst
formed
situ
Ni(acac)2
2,2′-bipyridine
DMF
at
ambient
temperatures.
reaction
showed
good
functional
group
compatibility,
heteroaryl
iodides,
such
as
thiophene
or
pyridine
derivatives,
were
well
accepted.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 19, 2024
Decarboxylative
cross-coupling
reactions
are
powerful
tools
for
carbon-heteroatom
bonds
formation,
but
typically
require
pre-activated
carboxylic
acids
as
substrates
or
heteroelectrophiles
functional
groups.
Herein,
we
present
an
electrochemical
decarboxylative
of
with
structurally
diverse
fluorine,
alcohol,
H
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(47)
Опубликована: Авг. 27, 2024
Abstract
Electroreduction
is
an
important
aspect
of
organic
electrochemistry.
Its
chemistry
does
not
require
the
addition
additional
reductants,
making
it
effective
alternative
to
various
traditional
reduction
reactions.
Among
them,
organo‐mediated
electroreduction
recognized
as
a
promising
approach.
Organo‐mediators
can
be
reduced
directly
at
cathode
form
reactive
radical
anions
that
subsequently
reduce
substrate
via
electron
transfer
(
ET
)
initiate
reaction
being
investigated.
typically
have
more
positive
potential,
and
their
role
in
whole
similar
catalysts.
Their
transforms
process
from
original
heterogeneous
into
homogeneous
one.
Organo‐mediated
effectively
avoid
over‐electrolysis
product
electrode
intolerance
sensitive
substrates
or
functional
groups
during
electrolysis,
thereby
preventing
occurrence
side
It
also
prevent
excessive
consumption
reagents
electrical
energy
while
promoting
achieve
higher
completely
different
selectivity.
Considering
advantages
this
type
reaction,
review
will
provide
detailed
description
reactions
mediated
by
molecules
recent
years
elucidate
mechanism
organo‐mediators
transformations.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
By
reacting
carboxylic
acids
with
dioxazolones
in
the
presence
of
a
base,
wide
variety
amides,
particularly
acylated
chiral
amines,
can
be
synthesized
through
decarboxylative
amidation.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(18), С. 13128 - 13136
Опубликована: Сен. 11, 2024
Herein,
we
report
the
Ag-catalyzed
substrate-controlled
interrupted
radical
pathways
of
iminyl
radical.
The
benzylic
groups
played
a
crucial
role
in
pathway
selection
involving
series
dimerization
and
hydrolysis,
1,5-H
shift
followed
by
cascade
cyclization,
direct
N-(sp
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(12)
Опубликована: Март 11, 2024
Lithium-Ion
BatteriesIn
their
Communication
(e202315628),
De-en
Jiang
et
al.
reveal
through
machine-learning
force
field
molecular
dynamics
simulations
the
superionic
Li
+
transport
in
glassy
LiTaCl
6
via
adynamic
"monkey
bar"
mechanism.
