Carrier‐Free Self‐Assembly Nano‐Sonosensitizers for Sonodynamic‐Amplified Cuproptosis‐Ferroptosis in Glioblastoma Therapy

Advanced Science, Год журнала: 2024, Номер 11(23)

Опубликована: Апрель 6, 2024

Abstract Cuproptosis is a newly discovered form of programmed cell death significantly depending on the transport efficacy copper (Cu) ionophores. However, existing Cu ionophores, primarily small molecules with short blood half‐life, face challenges in transporting enough amounts ions into tumor cells. This work describes construction carrier‐free nanoparticles (Ce6@Cu NPs), which self‐assembled by coordination 2+ sonosensitizer chlorin e6 (Ce6), facilitating sonodynamic‐triggered combination cuproptosis and ferroptosis. Ce6@Cu NPs internalized U87MG cells induce sonodynamic effect glutathione (GSH) depletion capability, promoting lipid peroxidation eventually inducing Furthermore, + concentration increases as reacts reductive GSH, resulting downregulation ferredoxin‐1 lipoyl synthase. induces oligomerization lipoylated dihydrolipoamide S‐acetyltransferase, causing proteotoxic stress irreversible cuproptosis. possess satisfactory ability to penetrate blood‐brain barrier, significant accumulation orthotopic U87MG‐Luc glioblastoma. The ferroptosis evidenced both vitro vivo minimal side effects. represents promising therapeutic strategy combining cuproptosis, potentially inspiring further research developing logical effective cancer therapies based

Язык: Английский

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Surface Oxygen Vacancies and Corona Polarization of Bi₄Ti₃O₁₂ Nanosheets for Synergistically Enhanced Sonopiezoelectric Therapy

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(32), С. 22348 - 22359

Опубликована: Авг. 1, 2024

Sonopiezoelectric therapy, an ultrasound-activated piezoelectric nanomaterial for tumor treatment, has emerged as a novel alternative modality. However, the limited catalytic efficiency is serious bottleneck its practical application. Excellent catalysts with high coefficients, good deformability, large mechanical impact surface area, and abundant catalytically active sites still need to be developed urgently. In this study, classical ferroelectric material, bismuth titanate (Bi4Ti3O12, BTO), selected sonopiezoelectric sensitizer therapy. BTO generates electron–hole pairs under ultrasonic irradiation, which can react substrates in sonocatalytic-driven redox reaction. Aiming further improve activity of BTO, modification oxygen vacancies treatment corona polarization are envisioned study. Notably, reduces bandgap inhibits recombination. Additionally, immobilized built-in electric field on promoting separation electrons holes. Consequently, these modifications greatly sonocatalytic situ generation cytotoxic ROS CO, effectively eradicating tumor.

Язык: Английский

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Sulfur-Vacancy-Engineered Two-Dimensional Cu@SnS_2–x Nanosheets Constructed via Heterovalent Substitution for High-Efficiency Piezocatalytic Tumor Therapy

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(31), С. 21496 - 21508

Опубликована: Июль 29, 2024

Ultrasound (US)-mediated piezocatalytic tumor therapy has attracted much attention due to its notable tissue-penetration capabilities, noninvasiveness, and low oxygen dependency. Nevertheless, the efficiency of is limited an inadequate piezoelectric response, separation electron–hole (e––h+) pairs, complex microenvironment (TME). Herein, ultrathin two-dimensional (2D) sulfur-vacancy-engineered (Sv-engineered) Cu@SnS2–x nanosheet (NS) with enhanced effect was constructed via heterovalent substitution strategy Sn4+ by Cu2+. The introduction Cu2+ ion not only causes changes in crystal structure increase polarization but also generates rich Sv decrease band gap from 2.16 1.62 eV inhibit e––h+ pairs recombination, collectively leading highly efficient generation reactive species under US irradiation. Moreover, shows US-enhanced TME-responsive Fenton-like catalytic activity glutathione depletion ability, further aggravating oxidative stress. Both vitro vivo results prove that Sv-engineered NSs can significantly kill cells achieve high-efficiency a biocompatible manner. Overall, this study provides new avenue for sonocatalytic broadens application 2D materials.

Язык: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

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Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Язык: Английский

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Small‐Bandgap Transducers Induced Carrier Separation for In Situ Dual‐Amplified Tumor Oxidative Stress

Advanced Functional Materials, Год журнала: 2024, Номер 34(34)

Опубликована: Май 7, 2024

Abstract The inherent and unique charge‐carrier release characteristics of piezoelectric sonosensitizers with desired bandgap can be leveraged to initiate reactive oxygen species (ROS) reactions that have considerable potential for sonodynamic therapy (SDT). In this study, a bimetallic Bi 4 NbO 8 Br‐polyvinylpyrrolidone (BNOBP) small (2.45 eV) is synthesized as sonosensitizer. robust interactions within between the Bi─O Nb─O layers narrow bandgap, facilitating carrier transfer. Concurrently, compared TiO 2 BiOBr, BNOBP exhibits rapid acoustoelectric response desirable electron–hole separation efficiency, enabling generation ·O − under ultrasound (US) irradiation. Notably, alleviates overexpression glutathione (GSH) in tumors prevents consumption generated ROS by GSH. Combining previous endow high study provides paradigm situ regulation oxidative stress levels tumor tissue microenvironment based on sonosensitizers.

Язык: Английский

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In Situ Construction of Fuzzy Sea‐Urchin ZnIn₂S₄/W₁₈O₄₉: Leveraging Interfacial Z‐Scheme Redox Sites toward Cooperative Electron–Hole Utilization in Photocatalysis

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 9, 2024

Abstract Despite the significant milestones in half‐reduction process of photocatalysis, challenges remain fully utilizing electron–hole pairs simultaneous redox reactions. Herein, a Z‐scheme ZnIn 2 S 4 /W 18 O 49 (ZW) hybrid with complementary band edge potential is situ constructed. The resultant fuzzy 1D‐assembled sea‐urchin photocatalyst demonstrates an optimal H and benzaldehyde yield 122 106 µmol h −1 under λ > 420 nm light irradiation. This sacrificial‐agent‐free system entails solar‐to‐hydrogen (STH) apparent quantum efficiency (AQE) values 0.466% 2.48% (420 nm), respectively, surpassing most recently reported photocatalytic systems without aid noble metal cocatalysts. outstanding performance mainly attributed to synergistic formation intimate heterojunction induction localized surface plasmon resonances. Comprehensive characterization studies prove direct injection energetic hot electrons promote number long‐lived active electrons. Besides, electron paramagnetic resonance scavenger tests clarify complicated mechanistic puzzle dual‐redox reaction, where formed dominantly via O─H activation followed by C─H cleavage benzyl alcohol over ZW hybrid. Lastly, universal use composites testified various systems. study offers novel outlook for designing dual‐functioning heterojunctions toward feasible photoredox application.

Язык: Английский

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Degradable and Piezoelectric Hollow ZnO Heterostructures for Sonodynamic Therapy and Pro-Death Autophagy

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 24, 2024

Piezoelectric materials can generate charges and reactive oxygen species (ROS) under external force stimulation for ultrasound-induced sonodynamic therapy (SDT). However, their poor piezoelectricity, fast electron–hole pair recombination rate, biological toxicity of piezoelectric limit the therapeutic effects SDT. In this study, hollow ZnO (HZnO) nanospheres were synthesized by using a one-step method. The structure facilitated deformation HZnO ultrasound mechanical increased constant. Subsequently, black phosphorus quantum dots (BPQDs) arginine-glycine-aspartic acid peptide (RGD)-poly(ethylene glycol) (PEG) combined with to further enhance effect constructing heterojunctions enable tumor-targeting ability. During treatment, HZnO-BPQDs-PEG could degrade in an acidic tumor microenvironment release Zn2+ PO43– ions induce pro-death autophagy. ROS produced SDT also accelerated autophagy promoted ferroptosis cancer cells. This study demonstrates that has strong effectively cells, providing new idea design application therapy.

Язык: Английский

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Acid‐Responsive Nanoregulators Elicit Hydrogen Sulfide‐Mediated Tumor Oxygenation and Selective Sonosensitization for Hypoxic Tumors

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Oxygen (O 2 ) tension within a tumor is considered hallmark of sonodynamic therapy (SDT). Herein, multifunctional nanoregulators, CMCS‐Au‐SrS (CAS), are reported, which assembled by carboxymethyl chitosan(CMCS) tethered gold nanoclusters (Au NCs) as sonosensitizers and sulfurate donors strontium sulfide nanoparticles (SrS NPs), to evoke selective SDT in hypoxic tumors. CAS possess tumor‐acidity responsiveness form large‐size aggregated Au NCs with shortened bandgap so that effectively induce powerful reactive oxygen species generation. On the other hand, acidity triggers degradation SrS NPs release hydrogen (H S), evoking oxygenation overcome hypoxia. This junction accelerated sonosensiting ability boosts amplified efficacy. More importantly, specific glycolysis induced acidification leads selectively accumulated cancer cells, further guaranteeing execution advanced therapeutic manners. Additionally, doping Nd 3+ endows second near‐infrared fluorescence facilitate vivo tracing property good tissue penetration (up 6 mm). strategy may play pioneering role develop theranostic reagents improved enrichment capacity enhanced hypoxia

Язык: Английский

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Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced effects. Specifically, introduction Co single atom not only induces lattice distortion out‐of‐plane polarization but also leads to formation numerous vacancies. These changes collectively narrow intrinsic bandgap material, facilitating effective separation migration charge carriers, enabling efficient production reactive oxygen species under ultrasound stimulation. Additionally, SA‐Co@MoS demonstrate improved enzymatic activity glutathione depletion capabilities attributed mixed valence states Co, intensifying oxidative stress cells, leading cell cycle arrest apoptosis, while inactivation peroxidase 4 ferroptosis. Both vitro vivo results indicate that can significantly eliminate cells. This study offers valuable insights into exploration doping‐enhanced sonosensitizers for cancer treatment, potentially paving way advancements field synergistic enzyodynamic therapy.

Язык: Английский

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