Targets,
Journal Year:
2024,
Volume and Issue:
2(4), P. 327 - 340
Published: Oct. 31, 2024
Afterglow
imaging
plays
a
crucial
role
in
the
cancer
treatment
field.
In
contrast
to
inorganic
afterglow
agents,
organic
agents
possess
easily
modifiable
structures
and
exhibit
excellent
biocompatibility,
thereby
presenting
significant
prospects
for
application
tumor
diagnosis
management.
this
review,
we
summarize
design
principles
applications
of
probes
therapy.
Finally,
discuss
future
challenges
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 22, 2024
Pyroptosis,
a
lytic
form
of
cell
death
mediated
by
the
gasdermin
family,
is
characterized
swelling
and
membrane
rupture.
Inducing
pyroptosis
in
cancer
cells
can
enhance
antitumor
immune
responses
promising
strategy
for
therapy.
However,
excessive
may
trigger
development
inflammatory
diseases
due
to
immoderate
continuous
reactions.
Nanomaterials
nanobiotechnology,
renowned
their
unique
advantages
diverse
structures,
have
garnered
increasing
attention
owing
potential
induce
such
as
cancer.
A
nano-delivery
system
drug-induced
overcome
limitations
small
molecules.
Furthermore,
nanomedicines
directly
manipulate
pyroptosis.
This
review
summarizes
discusses
latest
advancements
nanoparticle-based
treatments
with
among
cancer,
focusing
on
functions
mechanisms
providing
valuable
insights
into
selecting
nanodrugs
clinical
application
these
strategies
still
faces
challenges
limited
understanding
nanobiological
interactions.
Finally,
future
perspectives
emerging
field
pyroptotic
nanomaterials
are
presented.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(27), P. 34591 - 34606
Published: June 25, 2024
Immunotherapy
has
emerged
as
a
revolutionizing
therapeutic
modality
for
cancer.
However,
its
efficacy
been
largely
limited
by
weak
immune
response
and
an
immunosuppressive
tumor
microenvironment.
Herein,
we
report
metal–organic
framework
(MOF)-derived
titanium
oxide
nanoparticle
(MCTx
NP)
booster
that
can
greatly
improve
the
immunotherapy
inducing
"immunogenic
cell
death"
(ICD)
remodeling
The
NPs,
inheriting
characteristic
structure
of
MIL-125
enriched
with
oxygen
vacancies
(OVs),
demonstrate
both
high
photothermal
conversion
efficiency
reactive
species
(ROS)
generation
yield
upon
near-infrared
(NIR)
activation.
Moreover,
NPs
release
O2
reduce
glutathione
(GSH)
in
environment,
showcasing
their
potential
to
reverse
In
vitro/vivo
results
MCTx
directly
kill
cells
effectively
eliminate
primary
tumors
exerting
dual
photodynamic/photothermal
therapy
under
single
NIR
irritation.
At
same
time,
augment
PD-L1
blockade
potently
ICDs
reversing
microenvironment,
including
promoting
dendritic
(DC)
maturation,
decreasing
regulatory
T
(Tregs)'
infiltration,
increasing
cytotoxic
lymphocytes
(CTLs)
helper
(Ths),
resulting
effective
distant
suppression.
This
work
highlights
NP-mediated
photodynamic-
photothermal-enhanced
strategy
treatment.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 18, 2024
Ventricular
arrhythmias
(VAs)
triggered
by
myocardial
infarction
(MI)
are
the
leading
cause
of
sudden
cardiac
mortality
worldwide.
Current
therapeutic
strategies
for
managing
MI-induced
VAs,
such
as
left
stellate
ganglion
resection
and
ablation,
suboptimal,
highlighting
need
to
explore
safer
more
effective
intervention
strategies.
Herein,
we
rationally
designed
two
supramolecular
sonosensitizers
RuA
RuB,
engineered
through
acceptor
modification
generate
moderate
reactive
oxygen
species
(ROS)
modulate
VAs.
Both
RuB
demonstrated
high
ultrasound
(US)-activated
ROS
production
efficiency,
with
singlet
(
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Specifically
improving
the
intratumoral
accumulation
and
retention
achieving
maximum
therapeutic
efficacy
of
small-molecule
chemotherapeutics
remains
a
considerable
challenge.
To
address
issue,
we
here
reported
near-infrared
(NIR)
irradiation-activatable
targeted
covalent
nanodrugs
by
installing
diazirine-labeled
transferrin
receptor
1
(TfR1)-targeted
aptamers
on
PEGylated
phospholipid-coated
upconversion
nanoparticles
followed
doxorubicin
loading.
Targeted
recognized
then
were
activated
to
covalently
cross-link
with
TfR1
cancer
cells
980
nm
NIR
irradiation.
Systematic
studies
revealed
that
they
achieved
>6-
>5.5-fold
higher
accumulations
than
aptamer-based
at
6
120
h
post
intravenous
injection,
respectively.
Based
high
drug
delivery
efficacy,
boosted
doxorubicin-induced
immunogenic
cell
death,
antitumor
immune
responses
shrank
sizes
both
primary
distant
tumors,
displayed
better
less
adverse
effect
commercial
Doxil
in
4T1
syngeneic
breast
tumor
model
featuring
an
immunosuppressive
microenvironment.
By
integrating
specificity
molecular
recognition,
reactivity
profile
diazirine
accuracy
light
manipulation
nanodrug
supremacy,
our
could
be
expected
as
longer-term
efficient
strategy
improve
anticancer
chemotherapeutics.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Immunogenic
cell
death
(ICD)
has
attracted
enormous
attention
over
the
past
decade
due
to
its
unique
characteristics
in
cancer
and
role
activating
innate
adaptive
immune
responses
against
tumours.
Many
efforts
have
been
dedicated
screening,
identifying
discovering
ICD
inducers,
resulting
validation
of
several
based
on
metal
complexes.
In
this
review,
we
provide
a
comprehensive
summary
current
metal-based
their
molecular
mechanisms
for
triggering
initiation
subsequent
protective
antitumour
responses,
along
with
considerations
validating
both
vitro
vivo.
We
also
aim
offer
insights
into
future
development
complexes
enhanced
ICD-inducing
properties
applications
potentiating
immunity.
APL Materials,
Journal Year:
2025,
Volume and Issue:
13(5)
Published: May 1, 2025
Metal–organic
cycle/cages
(MOCs)
are
a
class
of
molecular
structures
characterized
by
their
unique
shapes
and
dimensions,
created
using
the
systematic
combination
an
organic
donor
metal
center.
Due
to
versatile
properties,
MOCs
highly
useful
in
materials
science.
Owing
structural
photoelectric
polycyclic
aromatic
hydrocarbons
have
significant
application
potential
optoelectronic
devices,
chemical
sensing,
biomedical
fields.
Fluorescent
constructed
with
units
such
as
anthracene
pyrene
backbones
show
fluorescence
properties
broad
applications
recognition,
bioimaging,
functional
materials.
This
review
highlights
latest
research
progress
on
these
multiple
areas,
including
luminescence,
resonance
energy
transfer,
host–guest
chemistry,
bioimaging.
In
addition,
design
strategies
related
involving
conformational
distortions
cycloaddition
reactions
discussed.
provides
summary
advances
this
field
during
past
three
years.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Abstract
The
recent
booming
development
of
sonometabolism
regulation
in
controlling
the
tumor
microenvironment
(TME)
has
opened
a
new
research
area
to
identify
innovative
approaches
against
cancer.
aim
this
review
is
highlight
potentials
and
advantages
sonodynamic
therapy
(SDT)
antitumor
nanotherapies,
specifically,
delineating
progress
made
SDT
concerning
TME
metabolism
which
encompasses
factors
such
as
hypoxia,
redox
balance,
autophagy,
immunosuppression,
ion
homeostasis,
other
metabolic
processes.
By
focusing
on
both
cell
dynamics,
wide
range
strategies
that
have
demonstrated
great
therapeutic
effectiveness
by
targeting
functions
inherent
are
summarized.
In
conclusion,
offers
valuable
insights
for
researchers
involved
SDT‐based
strategies,
with
advancing
methodologies
future
research.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 13, 2025
The
delayed
detection
and
recurrence
of
cancer
lead
to
disappointing
cure
rates,
underscoring
the
imperative
for
exploring
precise
early
tumor
diagnosis
techniques.
Despite
superior
biocompatibility
flexible
programmability
DNA
nanoprobes
imaging,
intricate
designs
with
multiple
oligonucleotide
sequences
are
always
indispensable,
which
significantly
hinder
their
clinical
application
commercial
development.
To
construct
a
simply
designed
nanoprobe,
here,
we
constructed
universal
stimuli-responsive
nanohydrogel
through
hybridization
staple
strand
skeleton
strand.
Through
simple
substitution
strand,
this
hydrogel
can
be
adapted
response
different
targets
without
necessitating
series
subsequent
revisions
synthesis
optimization.
achieve
near-infrared
II
region
(NIR-II)
fluorescence
alkynyl-modified
NIR-II
fluorescent
dyes
labeled
at
two
ends
bent
strands
display
weak
because
aggregation-caused
quenching
effect.
highly
expressed
ATP
or
cytokine
in
cells
activates
liberation
staples
collapse
configuration,
generates
recovery
imaging.
Moreover,
also
allows
targeted
release
anticancer
drugs
intercalated
helix.
By
integration
dyes,
versatile
enables
treatment
tumors.
straightforward
design
demonstrates
low
cost
easy
adaptability
multitarget
detection,
highlighting
its
significant
implications
advancement
nanotechnology
commercialization
production.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 4, 2025
Abstract
Type‐I
photosensitizers
(PSs)
are
considered
to
be
efficient
agents
for
overcoming
the
oxygen‐dependent
deficiency
of
traditional
photodynamic
therapy
(PDT).
However,
it
is
still
challenging
design
type‐I
PSs
that
can
activated
by
second
near‐infrared
(NIR‐II)
irradiation.
Herein,
a
series
organic
heavy‐atom‐free
molecules
designed
(named
as
CTU1
,
CTU2
and
CTU3
)
exhibit
strong
absorption
bands
over
first
NIR‐II
regions.
Among
them,
water‐dispersible
nanoparticles
(NPs)
show
J
‐aggregate
characteristics
good
band,
resulting
in
highly
•O
2
−
generation
upon
irradiation
1064
nm
light.
In
addition,
NPs
also
high
photothermal
conversion
efficiency
88.6%.
vitro
vivo
experiments
have
superior
PDT
(PTT)
effects,
which
further
induce
immunogenic
cell
death
activate
immune
cells
4T1
tumor‐bearing
mice
combined
PDT/PTT
anti‐tumor
photoimmunotherapy
against
refractory
tumors.
This
work
presents
paradigm
de
novo
light‐activated
PS
combinational
cancer.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 4, 2025
Abstract
Low
immunogenicity,
insufficient
immune
infiltrates,
and
inhibitive
microenvironment
of
tumors
ruthlessly
weakened
the
therapeutic
efficacy
immunotherapies.
How
to
improve
therapy
by
reshaping
tumor
still
remains
a
challenge
that
needs
be
urgently
addressed.
Here,
novel
dual‐defect
nitrogen‐rich
carbon
nitride‐based
heterostructural
nanocatalyst
(CNO@CuMS)
possessing
brilliant
piezocatalytic
H
2
O
generation,
sonocatalytic
1
Fenton‐like
catalytic
•OH
cell
cuproptosis
inducing
properties
are
developed.
Accompanied
ultrasonic
treatment,
immunogenic
death
(ICD)
subsequent
releasing
damage‐associated
molecular
patterns
(DAMPs)
cells
successfully
triggered
CNO@CuMS,
which
resulted
in
activation
systematic
antitumor
response
enhanced
infiltration
CD8
+
cytotoxic
T
lymphocytes
natural
killer
(NK)
at
site.
The
large
quantitatively
generated
reactive
oxygen
species
(ROS)
also
promoted
polarization
M2‐type
macrophage
M1‐type
as
well.
Benefitting
from
this
remodelling
effect,
remarkable
malignant
orthotopic
osteosarcoma
is
achieved
employing
CNO@CuMS
α
PD‐1
combination
strategy
under
with
no
significant
side
effects
observed.
This
research
not
only
proposes
method
fabricate
high
proformance
but
provides
new
realize
highly
efficient
bone
during
clinical
practice.
