Targets,
Journal Year:
2024,
Volume and Issue:
2(4), P. 327 - 340
Published: Oct. 31, 2024
Afterglow
imaging
plays
a
crucial
role
in
the
cancer
treatment
field.
In
contrast
to
inorganic
afterglow
agents,
organic
agents
possess
easily
modifiable
structures
and
exhibit
excellent
biocompatibility,
thereby
presenting
significant
prospects
for
application
tumor
diagnosis
management.
this
review,
we
summarize
design
principles
applications
of
probes
therapy.
Finally,
discuss
future
challenges
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 22, 2024
Pyroptosis,
a
lytic
form
of
cell
death
mediated
by
the
gasdermin
family,
is
characterized
swelling
and
membrane
rupture.
Inducing
pyroptosis
in
cancer
cells
can
enhance
antitumor
immune
responses
promising
strategy
for
therapy.
However,
excessive
may
trigger
development
inflammatory
diseases
due
to
immoderate
continuous
reactions.
Nanomaterials
nanobiotechnology,
renowned
their
unique
advantages
diverse
structures,
have
garnered
increasing
attention
owing
potential
induce
such
as
cancer.
A
nano-delivery
system
drug-induced
overcome
limitations
small
molecules.
Furthermore,
nanomedicines
directly
manipulate
pyroptosis.
This
review
summarizes
discusses
latest
advancements
nanoparticle-based
treatments
with
among
cancer,
focusing
on
functions
mechanisms
providing
valuable
insights
into
selecting
nanodrugs
clinical
application
these
strategies
still
faces
challenges
limited
understanding
nanobiological
interactions.
Finally,
future
perspectives
emerging
field
pyroptotic
nanomaterials
are
presented.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(27), P. 34591 - 34606
Published: June 25, 2024
Immunotherapy
has
emerged
as
a
revolutionizing
therapeutic
modality
for
cancer.
However,
its
efficacy
been
largely
limited
by
weak
immune
response
and
an
immunosuppressive
tumor
microenvironment.
Herein,
we
report
metal–organic
framework
(MOF)-derived
titanium
oxide
nanoparticle
(MCTx
NP)
booster
that
can
greatly
improve
the
immunotherapy
inducing
"immunogenic
cell
death"
(ICD)
remodeling
The
NPs,
inheriting
characteristic
structure
of
MIL-125
enriched
with
oxygen
vacancies
(OVs),
demonstrate
both
high
photothermal
conversion
efficiency
reactive
species
(ROS)
generation
yield
upon
near-infrared
(NIR)
activation.
Moreover,
NPs
release
O2
reduce
glutathione
(GSH)
in
environment,
showcasing
their
potential
to
reverse
In
vitro/vivo
results
MCTx
directly
kill
cells
effectively
eliminate
primary
tumors
exerting
dual
photodynamic/photothermal
therapy
under
single
NIR
irritation.
At
same
time,
augment
PD-L1
blockade
potently
ICDs
reversing
microenvironment,
including
promoting
dendritic
(DC)
maturation,
decreasing
regulatory
T
(Tregs)'
infiltration,
increasing
cytotoxic
lymphocytes
(CTLs)
helper
(Ths),
resulting
effective
distant
suppression.
This
work
highlights
NP-mediated
photodynamic-
photothermal-enhanced
strategy
treatment.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Specifically
improving
the
intratumoral
accumulation
and
retention
achieving
maximum
therapeutic
efficacy
of
small-molecule
chemotherapeutics
remains
a
considerable
challenge.
To
address
issue,
we
here
reported
near-infrared
(NIR)
irradiation-activatable
targeted
covalent
nanodrugs
by
installing
diazirine-labeled
transferrin
receptor
1
(TfR1)-targeted
aptamers
on
PEGylated
phospholipid-coated
upconversion
nanoparticles
followed
doxorubicin
loading.
Targeted
recognized
then
were
activated
to
covalently
cross-link
with
TfR1
cancer
cells
980
nm
NIR
irradiation.
Systematic
studies
revealed
that
they
achieved
>6-
>5.5-fold
higher
accumulations
than
aptamer-based
at
6
120
h
post
intravenous
injection,
respectively.
Based
high
drug
delivery
efficacy,
boosted
doxorubicin-induced
immunogenic
cell
death,
antitumor
immune
responses
shrank
sizes
both
primary
distant
tumors,
displayed
better
less
adverse
effect
commercial
Doxil
in
4T1
syngeneic
breast
tumor
model
featuring
an
immunosuppressive
microenvironment.
By
integrating
specificity
molecular
recognition,
reactivity
profile
diazirine
accuracy
light
manipulation
nanodrug
supremacy,
our
could
be
expected
as
longer-term
efficient
strategy
improve
anticancer
chemotherapeutics.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Immunogenic
cell
death
(ICD)
has
attracted
enormous
attention
over
the
past
decade
due
to
its
unique
characteristics
in
cancer
and
role
activating
innate
adaptive
immune
responses
against
tumours.
Many
efforts
have
been
dedicated
screening,
identifying
discovering
ICD
inducers,
resulting
validation
of
several
based
on
metal
complexes.
In
this
review,
we
provide
a
comprehensive
summary
current
metal-based
their
molecular
mechanisms
for
triggering
initiation
subsequent
protective
antitumour
responses,
along
with
considerations
validating
both
vitro
vivo.
We
also
aim
offer
insights
into
future
development
complexes
enhanced
ICD-inducing
properties
applications
potentiating
immunity.
APL Materials,
Journal Year:
2025,
Volume and Issue:
13(5)
Published: May 1, 2025
Metal–organic
cycle/cages
(MOCs)
are
a
class
of
molecular
structures
characterized
by
their
unique
shapes
and
dimensions,
created
using
the
systematic
combination
an
organic
donor
metal
center.
Due
to
versatile
properties,
MOCs
highly
useful
in
materials
science.
Owing
structural
photoelectric
polycyclic
aromatic
hydrocarbons
have
significant
application
potential
optoelectronic
devices,
chemical
sensing,
biomedical
fields.
Fluorescent
constructed
with
units
such
as
anthracene
pyrene
backbones
show
fluorescence
properties
broad
applications
recognition,
bioimaging,
functional
materials.
This
review
highlights
latest
research
progress
on
these
multiple
areas,
including
luminescence,
resonance
energy
transfer,
host–guest
chemistry,
bioimaging.
In
addition,
design
strategies
related
involving
conformational
distortions
cycloaddition
reactions
discussed.
provides
summary
advances
this
field
during
past
three
years.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Abstract
The
recent
booming
development
of
sonometabolism
regulation
in
controlling
the
tumor
microenvironment
(TME)
has
opened
a
new
research
area
to
identify
innovative
approaches
against
cancer.
aim
this
review
is
highlight
potentials
and
advantages
sonodynamic
therapy
(SDT)
antitumor
nanotherapies,
specifically,
delineating
progress
made
SDT
concerning
TME
metabolism
which
encompasses
factors
such
as
hypoxia,
redox
balance,
autophagy,
immunosuppression,
ion
homeostasis,
other
metabolic
processes.
By
focusing
on
both
cell
dynamics,
wide
range
strategies
that
have
demonstrated
great
therapeutic
effectiveness
by
targeting
functions
inherent
are
summarized.
In
conclusion,
offers
valuable
insights
for
researchers
involved
SDT‐based
strategies,
with
advancing
methodologies
future
research.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 18, 2024
Ventricular
arrhythmias
(VAs)
triggered
by
myocardial
infarction
(MI)
are
the
leading
cause
of
sudden
cardiac
mortality
worldwide.
Current
therapeutic
strategies
for
managing
MI-induced
VAs,
such
as
left
stellate
ganglion
resection
and
ablation,
suboptimal,
highlighting
need
to
explore
safer
more
effective
intervention
strategies.
Herein,
we
rationally
designed
two
supramolecular
sonosensitizers
RuA
RuB,
engineered
through
acceptor
modification
generate
moderate
reactive
oxygen
species
(ROS)
modulate
VAs.
Both
RuB
demonstrated
high
ultrasound
(US)-activated
ROS
production
efficiency,
with
singlet
(
Sonodynamic
therapy
(SDT)
can
generate
reactive
oxygen
species
(ROS)
to
combat
multidrug-resistant
biofilms,
which
pose
significant
challenges
human
health.
As
the
key
producing
ROS
in
SDT,
design
of
sonosensitizers
with
optimal
molecular
structures
for
sufficient
generation
and
activity
complex
biofilm
matrix
is
essential.
In
this
study,
we
propose
a
π-expansion
strategy
synthesize
series
small-molecule
metal
Ru(II)
complexes
(
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 15, 2024
Abstract
The
assembly
of
low‐immunogenic
poly(ethylene
glycol)
nanoparticles
(PEG
NPs)
for
targeted
delivery
therapeutics
(i.e.,
mitoxantrone
and
imidazoquinoline)
improved
photothermal‐immunotherapy
is
reported.
PEG
NPs
incorporating
targeting
molecules
hyaluronic
acid
are
engineered
via
the
templating
metal–organic
frameworks,
which
can
circumvent
accelerated
blood
clearance
exhibit
prolonged
circulation
time
as
well
accumulation
at
tumor
sites.
under
laser
radiation
induces
immunogenic
cell
death
cells,
combined
with
toll‐like
receptor
7/8
agonists
imidazoquinoline
to
trigger
immune
responses
cytotoxic
T
lymphocytes
eradication
cells.
Furthermore,
treatment
induce
tumor‐specific
that
inhibit
metastatic
lung
growth.
This
reported
provide
a
rational
design
cancer
immunotherapy.
