International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141463 - 141463
Опубликована: Март 1, 2025
Язык: Английский
RSC Advances, Год журнала: 2024, Номер 14(5), С. 3359 - 3378
Опубликована: Янв. 1, 2024
Electrostatic spinning as a technique for producing nanoscale fibers has recently attracted increasing attention due to its simplicity, versatility, and loadability.
Язык: Английский
Процитировано
32
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 266, С. 131207 - 131207
Опубликована: Март 28, 2024
Язык: Английский
Процитировано
24
Pharmaceutics, Год журнала: 2024, Номер 16(1), С. 93 - 93
Опубликована: Янв. 10, 2024
Wounds and chronic wounds can be caused by bacterial infections lead to discomfort in patients. To solve this problem, scientists are working create modern wound dressings with antibacterial additives, mainly because traditional materials cannot meet the general requirements for complex promote healing. This demand is met material engineering, through which we electrospun dressings. Electrospun dressings, as well those based on hydrogels incorporated compounds, these requirements. manuscript reviews recent used discussing their formation, application, functionalization. The focus presenting hydrogels. In contrast, advancements care have highlighted potential of thermoresponsive dynamic These contain adaptable polymers that offer targeted drug delivery show promise managing various types while addressing infections. way, article intended serve a compendium knowledge researchers, medical practitioners, biomaterials engineers, providing up-to-date information state art, possibilities innovative solutions, challenges area
Язык: Английский
Процитировано
18
Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
ABSTRACT Wound healing, especially for severe injuries, require dressings that absorb exudate, prevent infection, and support healing without causing trauma upon removal. Traditional single‐layered often fail to balance moisture retention protection, hindering optimal healing. To address this, a bilayered scaffold was fabricated comprising an electrospun hydrophilic sublayer of Pullulan/Polyvinyl alcohol (PVA)/Gum arabic blend loaded with Gentamicin solvent‐casted hydrophobic top layer Polylactic acid (PLA). The designed direct wound contact ease dressing removal, while the enhance mechanical properties, loss, protect against external environment. exhibited antibacterial activity Staphylococcus aureus Escherichia coli , controlled release 93.09% ± 2.63% within 48 h, best described by zero‐order model ( R 2 = 0.9850). It demonstrated swelling index 611.85% 15.05%, indicating its excellent exudate absorbing capacity. water vapor transmission rate (WVTR) porosity were 94.20 14.50 g/m /day 70.56% 0.58%, respectively, both falling permissible range Additionally, in vitro biocompatibility assays conducted on human dermal fibroblast (HDF) cells confirmed noncytotoxicity applicability applications.
Язык: Английский
Процитировано
2
Polymer-Plastics Technology and Materials, Год журнала: 2024, Номер 64(4), С. 397 - 438
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
11
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(8)
Опубликована: Янв. 26, 2024
Abstract How to promote wound healing is still a major challenge in the healthcare while macrophages are critical component of process. Compared various bioactive drugs, many plants have been reported facilitate process by regulating immune response wounds. In this work, Three‐dimensional (3D) printed hydrogel scaffold loaded with natural Centella asiatica extract (CA extract) developed for healing. This CA@3D uses gelatin (Gel) and sodium alginate (SA) CA as bio‐ink 3D printing. The contains variety compounds that make active ingredients work concert. can fit shape wound, orchestrate responses within compared commercial dressings. underlying mechanism promoting also illuminated applying multi‐omic analyses. Moreover, showed great ability diabetic chronic Due its ease preparation, low‐cost, biosafety, therapeutic outcomes, proposes an effective strategy
Язык: Английский
Процитировано
10
International Journal of Pharmaceutics, Год журнала: 2024, Номер 656, С. 124099 - 124099
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
10
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(15), С. 17707 - 17718
Опубликована: Июль 25, 2024
Wound-associated infections represent an arduous global healthcare challenge, especially in the "post-antibiotic" era, necessitating development of advanced antimicrobial dressing materials that simultaneously dictate use rapid yet effective disinfection, low drug resistance and side effects, potency to foster tissue healing. Nanoantimicrobial-armored nanostructured functional systems have piqued extensive interest satisfy these criteria. Herein, fusing electrospinning nanotechnology emerging photo–chemo synergistic sterilization paradigm, a smart "all-in-one" multifunctional wound-managing platform was constructed, through incorporating photochemically active nanocrystalline cuprous oxide (Cu2O) into modified polycaprolactone (mPCL) electrospun fibrous mats. The resulting were systematically characterized pertaining physiochemical analysis, photoabsorption photocurrent measurements, photocatalytic reactive oxygen species (ROS) generation. capability this nanoplatform elicit rapid, photoactivated, catalytically augmented bacterial disinfection corroborated, displaying ∼99–100% broad-spectrum antibacterial efficacies against Staphylococcus aureus Escherichia coli 25 min. Benefiting from release Cu2+, mPCL-Cu2O impairs contamination even under dark conditions. Furthermore, also exhibited favorable vitro/-ovo biocompatibility toward NIH3T3 fibroblasts, red blood cells, chick chorioallantoic membrane, alongside appreciable pro-healing capacity bridging scratch-based wounds, which could be attributed nanofiber-afforded biomimetic topography controllable liberation micronutrient Cu ions. This study provides insights design fabrication simple nanoplatforms for biomedical applications.
Язык: Английский
Процитировано
8
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 297, С. 139921 - 139921
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
1
Polymers, Год журнала: 2024, Номер 16(10), С. 1333 - 1333
Опубликована: Май 9, 2024
Traditional wound dressings have not been able to satisfy the needs of regenerative medicine biomedical area. With aim improving tissue regeneration, nanofiber-based fabricated by electrospinning (ES) processes emerged as a powerful approach. Nowadays, bioactive are mainly developed with combination natural and synthetic polymers, such polycaprolactone (PCL) chitosan (CHI). Accordingly, herein, PCL/CHI nanofibers varying PCL:CHI weight ratios (9:1, 8:2 7:3) or CHI viscosities (20, 100 600 mPa·s) using novel alternating current ES (ACES) process. Such were thoroughly characterized determining physicochemical nanomechanical properties, along wettability, absorption capacity hydrolytic plus enzymatic stability. Furthermore, nanofiber biological safety was validated in terms cytocompatibility hemocompatibility (hemolysis < 2%), addition notable antibacterial performance (bacterial reductions 99.90% for S. aureus 99.91% P. aeruginosa). Lastly, enhanced healing activity confirmed thanks their ability remarkably promote cell proliferation, which make them ideal candidates long-term applications dressings.
Язык: Английский
Процитировано
7