Child and Adolescent Psychiatric Clinics of North America, Год журнала: 2020, Номер 30(1), С. 27 - 45
Опубликована: Окт. 20, 2020
Язык: Английский
Sleep Medicine Reviews, Год журнала: 2021, Номер 57, С. 101472 - 101472
Опубликована: Март 14, 2021
Язык: Английский
Процитировано
174
Frontiers in Neuroscience, Год журнала: 2019, Номер 13
Опубликована: Июнь 5, 2019
In spite of the uniform appearance sleep as a behavior, sleeping brain does not produce electrical activities in unison. Different types rhythms arise during and vary between layers, areas, or from one functional system to another. Local heterogeneity such activities, here referred local sleep, overturns fundamental tenets globally regulated state. However, little is still known about neuronal circuits involved how they can generate their own specifically-tuned patterns. NREM patterns emerge interplay activity thalamic cortical networks. Within this circuitry, it now turns out that reticular nucleus (TRN) acts key player control. This based on marked TRN terms its cellular synaptic architecture, which leads regional diversity hallmarks, spindles, delta waves slow oscillations. provides first evidence for subcortical circuit determinant features. Here, we review novel insights supporting these elements come together account sleep. We also discuss open questions arising studies, focusing mechanisms regulation role plasticity cognitive functions.
Язык: Английский
Процитировано
88
Science Advances, Год журнала: 2020, Номер 6(38)
Опубликована: Сен. 18, 2020
Discovery of how sleep function shifts from neural reorganization to repair by combining mathematical theory and data analysis.
Язык: Английский
Процитировано
78
Acta Paediatrica, Год журнала: 2020, Номер 110(1), С. 36 - 44
Опубликована: Июль 16, 2020
Understanding the links between sleep and brain development is important, as rapid eye movement (REM) non-REM (NREM) seem to contribute different aspects of maturation. If children have problems, REM NREM are likely consequences for their developing brain, depending on age. We highlight important discoveries from human animal research role plays in development. A hypothetical model presented explain dynamic relationship with processes maturation, implications current neonatal care future research.
Язык: Английский
Процитировано
56
Pediatric Research, Год журнала: 2021, Номер 91(4), С. 771 - 786
Опубликована: Апрель 15, 2021
Язык: Английский
Процитировано
51
Current Biology, Год журнала: 2019, Номер 29(12), С. 1976 - 1987.e4
Опубликована: Май 30, 2019
Язык: Английский
Процитировано
54
Current Opinion in Physiology, Год журнала: 2019, Номер 15, С. 14 - 22
Опубликована: Ноя. 18, 2019
Язык: Английский
Процитировано
50
Current Sleep Medicine Reports, Год журнала: 2020, Номер 6(4), С. 267 - 279
Опубликована: Ноя. 13, 2020
Язык: Английский
Процитировано
46
Journal of Neuroscience, Год журнала: 2021, Номер 41(15), С. 3418 - 3431
Опубликована: Фев. 23, 2021
It is generally supposed that primary motor cortex (M1) receives somatosensory input predominantly via (S1). However, a growing body of evidence indicates M1 also direct sensory from the thalamus, independent S1; such particularly evident at early ages before contributes to control. Here, recording extracellularly forelimb regions S1 and in unanesthetized rats postnatal day (P)8 P12, we compared responses self-generated (i.e., reafferent) movements during active sleep wake, other-generated exafferent) movements. At both ages, reafferent were processed parallel by M1; contrast, exafferent P8 but serially, M1, P12. To further assess this developmental difference processing, proprioceptive tactile stimulation. stimulation evoked whereas serial Independent submodality stimulation, pairs S1-M1 units exhibited greater coactivation than wake. These results indicate independently develop somatotopy establishing interactive relationship typifies their functionality adults. SIGNIFICANCE STATEMENT Learning any new task depends on ability use information update outflow. Thus, understand learning, must how animals process input. Primary (S1) are two interdependent structures throughout life. In adults, functional between well established; however, little known about begin transmit or study, investigate development as processing unit. Our findings provide insights into fundamental principles connectivity these important sensorimotor structures.
Язык: Английский
Процитировано
41
Progress in Neurobiology, Год журнала: 2021, Номер 209, С. 102208 - 102208
Опубликована: Дек. 16, 2021
Sleep disorders have been linked to alterations of gut microbiota composition in adult humans and animal models, but it is unclear how this link develops. With longitudinal assessments 162 healthy infants, we present a so far unrecognized sleep-brain-gut interrelationship. First, report between sleep habits microbiota: daytime associated with bacterial diversity, nighttime fragmentation variability are maturity enterotype. Second, demonstrate link: diversity enterotype neurophysiology. Third, show that the relevant development: markers predict behavioral-developmental outcomes. Our results dynamic interplay sleep, microbiota, maturation brain behavior during infancy, which aligns newly emerging concept axis. Importantly, represent promising health targets since both can be modified non-invasively. As many diseases root early childhood, leveraging protective factors adequate age-appropriate infancy could constitute promoting factor across entire human lifespan.
Язык: Английский
Процитировано
34