Molecular Pharmaceutics,
Год журнала:
2023,
Номер
20(2), С. 1269 - 1284
Опубликована: Янв. 20, 2023
Diabetes
mellitus
(DM)
is
a
metabolic
disorder
that
one
of
the
most
common
health
problems
in
world,
primarily
type
2
DM
(T2DM).
Metformin
(MTF),
as
first-line
treatment
DMT2,
effective
lowering
glucose
levels,
but
its
oral
administration
causes
problems,
including
gastrointestinal
side
effects,
low
bioavailability,
and
risk
hypoglycemia.
In
this
study,
we
formulated
MTF
into
microparticles
incorporating
glucose-responsive
polymer
(MP–MTF–GR),
which
could
potentially
increase
bioavailability
extend
control
release
according
to
levels.
This
system
was
delivered
by
dissolving
microneedles
(MP–MTF–GR–DMN),
applied
through
skin,
thereby
preventing
effects
orally
administered
MTF.
MP–MTF–GR
using
various
concentrations
gelatin
combined
with
phenylboronic
acid
(PBA)
material.
encapsulated
DMN
polyvinyl
pyrrolidone
(PVP)
alcohol
(PVA)
polymers.
The
physicochemical
evaluation
showed
be
completely
entrapped
MP
percentage
trapped
increasing
concentration
without
changing
chemical
structure
producing
stable
MP.
addition,
results
MP–MTF–GR–DMN
had
adequate
mechanical
strength
properties
penetration
ability
environmental
changes.
vitro
ex
vivo
permeation
study
on
media
from
formula
increased
levels
media.
successfully
skin
at
11.30
±
0.29,
23.31
1.64,
36.12
3.77,
53.09
3.01
μg
PBS,
PBS
+
1%,
2%,
4%,
respectively,
24
h,
indicates
behavior.
developed
also
proven
nontoxic
based
hemolysis
tests.
Importantly,
rat
model
combination
approach
provide
better
reduction
compared
other
routes,
reducing
blood
level
normal
after
3
h
maintaining
for
8
h.
Furthermore,
did
not
change
moisture
rats.
promising
alternative
delivery
overcome
effectiveness
T2DM
therapy.
Chemical Reviews,
Год журнала:
2024,
Номер
124(9), С. 5505 - 5616
Опубликована: Апрель 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Particuology,
Год журнала:
2021,
Номер
64, С. 85 - 97
Опубликована: Июнь 8, 2021
Emulsions
are
liquid–liquid
dispersions
with
one
liquid
phase
dispersed
in
the
other
as
small
droplets.
Nanoemulsions
nano-sized
emulsions
sizes
ranging
from
tens
to
hundreds
of
nanometers,
and
have
great
potential
applications
pharmaceutics,
foods
cosmetics
due
their
attractive
properties,
such
sizes,
high
surface
area
per
unit
volume,
improved
dispersion
active
hydrophobic
components
enhanced
absorption.
The
article
provides
an
overview
nanoemulsions
for
drug
delivery,
starting
introduction
emulsion
types,
nanoemulsion
preparation
stability.
Surfactants
play
critical
roles
producing
stabilizing
nanoemulsions.
Different
types
surfactants
summarized
including
molecule
surfactants,
particle
phospholipids,
peptide
protein
surfactants.
Then
nanomedicine
delivery
presented.
Finally,
clinical
discussed.
Abstract
Nanoparticles
(NPs)
have
attracted
tremendous
interest
in
drug
delivery
the
past
decades.
Microfluidics
offers
a
promising
strategy
for
making
NPs
due
to
its
capability
precisely
controlling
NP
properties.
The
recent
success
of
mRNA
vaccines
using
microfluidics
represents
big
milestone
microfluidic
pharmaceutical
applications,
and
rapid
scaling
up
demonstrates
feasibility
industrial‐scale
manufacturing.
This
article
provides
critical
review
progress
delivery.
First,
synthesis
organic
focusing
on
typical
methods
their
applications
popular
clinically
relevant
NPs,
such
as
liposomes,
lipid
polymer
well
mechanisms
are
summarized.
Then,
several
representative
inorganic
(e.g.,
silica,
metal,
metal
oxide,
quantum
dots),
hybrid
is
discussed.
Lastly,
various
presented.
Materials Today Bio,
Год журнала:
2022,
Номер
13, С. 100208 - 100208
Опубликована: Янв. 1, 2022
Nanotechnology
in
medical
applications,
especially
oncology
as
drug
delivery
systems,
has
recently
shown
promising
results.
However,
although
these
advances
have
been
the
pre-clinical
stages,
clinical
translation
of
this
technology
is
challenging.
To
create
systems
with
increased
treatment
efficacy
for
translation,
physicochemical
characteristics
nanoparticles
such
size,
shape,
elasticity
(flexibility/rigidity),
surface
chemistry,
and
charge
can
be
specified
to
optimize
efficiency
a
given
application.
Consequently,
interdisciplinary
researchers
focused
on
producing
biocompatible
materials,
production
technologies,
or
new
formulations
efficient
loading,
high
stability.
The
effects
design
parameters
studied
Advances in Colloid and Interface Science,
Год журнала:
2024,
Номер
332, С. 103263 - 103263
Опубликована: Июль 31, 2024
The
growing
field
of
nanotechnology
has
witnessed
numerous
advancements
over
the
past
few
years,
particularly
in
development
engineered
nanoparticles.
Compared
with
bulk
materials,
metal
nanoparticles
possess
more
favorable
properties,
such
as
increased
chemical
activity
and
toxicity,
owing
to
their
smaller
size
larger
surface
area.
Metal
exhibit
exceptional
stability,
specificity,
sensitivity,
effectiveness,
making
them
highly
useful
biomedical
field.
are
high
demand
nanotechnology,
including
Au,
Ag,
Pt,
Cu,
Zn,
Co,
Gd,
Eu,
Er.
These
particles
excellent
physicochemical
amenable
functionalization,
non-corrosiveness,
varying
optical
electronic
properties
based
on
shape.
can
be
modified
different
targeting
agents
antibodies,
liposomes,
transferrin,
folic
acid,
carbohydrates.
Thus,
hold
great
promise
for
various
applications
photoacoustic
imaging,
magnetic
resonance
computed
tomography
(CT),
photothermal,
photodynamic
therapy
(PDT).
Despite
potential,
safety
considerations,
regulatory
hurdles
must
addressed
safe
clinical
applications.
This
review
highlights
nanoparticle
engineering
explores
integration
emerging
technologies
bioimaging,
cancer
therapeutics
nanomedicine.
By
offering
valuable
insights,
this
comprehensive
offers
a
deep
understanding
potential
research.
RSC Advances,
Год журнала:
2024,
Номер
14(41), С. 30201 - 30229
Опубликована: Янв. 1, 2024
Recently,
metal-organic
frameworks
(MOFs)
have
attracted
much
attention
as
versatile
materials
for
drug
delivery
and
personalized
medicine.
MOFs
are
porous
structures
made
up
of
metal
ions
coupled
with
organic
ligands.
This
review
highlights
the
synthesis
techniques
used
to
design
specific
features
such
surface
area
pore
size,
encapsulation
within
not
only
improves
their
stability
solubility
but
also
allows
controlled
release
kinetics,
which
therapeutic
efficacy
minimizes
adverse
effects.
Furthermore,
it
discusses
challenges
potential
advantages
MOF-based
delivery,
MOF
stability,
biocompatibility,
scale-up
production.
With
further
advancements
in
synthesis,
functionalization
techniques,
understanding
interactions
using
biological
systems,
can
significant
promise
expanding
medicine
improving
patient
outcomes.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Retinal
diseases
can
severely
impair
vision
and
even
lead
to
blindness,
posing
significant
threats
both
physical
mental
health.
Physical
retinal
regenerative
therapies
are
poised
revolutionize
the
treatment
of
various
disorders
associated
with
blindness.
However,
these
must
overcome
challenges
posed
by
protective
inner
outer
blood‒retinal
barriers.
Nanotechnology
applications
in
ophthalmology
have
shown
great
potential
addressing
issue
drug
delivery
eye.
Moreover,
nanotechnology-based
therapeutics
profound
clinical
impacts
on
retinopathy,
particularly
regeneration,
thereby
improving
patient
outcomes.
Continuous
advancements
nanotechnology
being
applied
regenerate
lost
or
damaged
eye
tissues
treat
loss
blindness
caused
degenerative
diseases.
These
approaches
be
categorized
into
three
main
strategies:
i)
nanoparticles
for
delivering
drugs,
genes,
other
essential
substances;
ii)
nanoscaffolds
providing
biocompatible
support;
iii)
nanocomposites
enhancing
functionality
primary
stem
cells.
The
aim
this
comprehensive
review
is
present
current
understanding
a
focus
perspective
functions
nanomaterials.
