Glucose-Responsive Microparticle-Loaded Dissolving Microneedles for Selective Delivery of Metformin: A Proof-of-Concept Study DOI

Nur Syafika,

Sumayya Binti Abdul Azis,

Cindy Kristina Enggi

et al.

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(2), P. 1269 - 1284

Published: Jan. 20, 2023

Diabetes mellitus (DM) is a metabolic disorder that one of the most common health problems in world, primarily type 2 DM (T2DM). Metformin (MTF), as first-line treatment DMT2, effective lowering glucose levels, but its oral administration causes problems, including gastrointestinal side effects, low bioavailability, and risk hypoglycemia. In this study, we formulated MTF into microparticles incorporating glucose-responsive polymer (MP–MTF–GR), which could potentially increase bioavailability extend control release according to levels. This system was delivered by dissolving microneedles (MP–MTF–GR–DMN), applied through skin, thereby preventing effects orally administered MTF. MP–MTF–GR using various concentrations gelatin combined with phenylboronic acid (PBA) material. encapsulated DMN polyvinyl pyrrolidone (PVP) alcohol (PVA) polymers. The physicochemical evaluation showed be completely entrapped MP percentage trapped increasing concentration without changing chemical structure producing stable MP. addition, results MP–MTF–GR–DMN had adequate mechanical strength properties penetration ability environmental changes. vitro ex vivo permeation study on media from formula increased levels media. successfully skin at 11.30 ± 0.29, 23.31 1.64, 36.12 3.77, 53.09 3.01 μg PBS, PBS + 1%, 2%, 4%, respectively, 24 h, indicates behavior. developed also proven nontoxic based hemolysis tests. Importantly, rat model combination approach provide better reduction compared other routes, reducing blood level normal after 3 h maintaining for 8 h. Furthermore, did not change moisture rats. promising alternative delivery overcome effectiveness T2DM therapy.

Language: Английский

Polymeric Nanoparticles for Drug Delivery DOI
Maximilian A. Beach,

Umeka Nayanathara,

Yanting Gao

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

Citations

236
Nanoemulsions for drug delivery DOI Creative Commons
Russell J. Wilson, Yang Li, Guangze Yang

et al.

Particuology, Journal Year: 2021, Volume and Issue: 64, P. 85 - 97

Published: June 8, 2021

Emulsions are liquid–liquid dispersions with one liquid phase dispersed in the other as small droplets. Nanoemulsions nano-sized emulsions sizes ranging from tens to hundreds of nanometers, and have great potential applications pharmaceutics, foods cosmetics due their attractive properties, such sizes, high surface area per unit volume, improved dispersion active hydrophobic components enhanced absorption. The article provides an overview nanoemulsions for drug delivery, starting introduction emulsion types, nanoemulsion preparation stability. Surfactants play critical roles producing stabilizing nanoemulsions. Different types surfactants summarized including molecule surfactants, particle phospholipids, peptide protein surfactants. Then nanomedicine delivery presented. Finally, clinical discussed.

Language: Английский

Citations

195
Microfluidic Nanoparticles for Drug Delivery DOI Creative Commons
Yun Liu, Guangze Yang, Yue Hui

et al.

Small, Journal Year: 2022, Volume and Issue: 18(36)

Published: April 9, 2022

Abstract Nanoparticles (NPs) have attracted tremendous interest in drug delivery the past decades. Microfluidics offers a promising strategy for making NPs due to its capability precisely controlling NP properties. The recent success of mRNA vaccines using microfluidics represents big milestone microfluidic pharmaceutical applications, and rapid scaling up demonstrates feasibility industrial‐scale manufacturing. This article provides critical review progress delivery. First, synthesis organic focusing on typical methods their applications popular clinically relevant NPs, such as liposomes, lipid polymer well mechanisms are summarized. Then, several representative inorganic (e.g., silica, metal, metal oxide, quantum dots), hybrid is discussed. Lastly, various presented.

Language: Английский

Citations

174
Towards principled design of cancer nanomedicine to accelerate clinical translation DOI Creative Commons
Mohammad Souri, M. Soltani, Farshad Moradi Kashkooli

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 13, P. 100208 - 100208

Published: Jan. 1, 2022

Nanotechnology in medical applications, especially oncology as drug delivery systems, has recently shown promising results. However, although these advances have been the pre-clinical stages, clinical translation of this technology is challenging. To create systems with increased treatment efficacy for translation, physicochemical characteristics nanoparticles such size, shape, elasticity (flexibility/rigidity), surface chemistry, and charge can be specified to optimize efficiency a given application. Consequently, interdisciplinary researchers focused on producing biocompatible materials, production technologies, or new formulations efficient loading, high stability. The effects design parameters studied

Language: Английский

Citations

105
Nano-based eye drop: Topical and noninvasive therapy for ocular diseases DOI
Chuhan Wang, Yan Pang

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 194, P. 114721 - 114721

Published: Feb. 10, 2023

Language: Английский

Citations

56
Effects of nanoparticle size, shape, and zeta potential on drug delivery DOI

Kıvılcım Öztürk,

Meryem Kaplan, Sema Çalış

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124799 - 124799

Published: Oct. 1, 2024

Language: Английский

Citations

47
Precision-engineered metal and metal-oxide nanoparticles for biomedical imaging and healthcare applications DOI Creative Commons

Thi Thuy Truong,

Sudip Mondal,

Vu Hoang Minh Doan

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 332, P. 103263 - 103263

Published: July 31, 2024

The growing field of nanotechnology has witnessed numerous advancements over the past few years, particularly in development engineered nanoparticles. Compared with bulk materials, metal nanoparticles possess more favorable properties, such as increased chemical activity and toxicity, owing to their smaller size larger surface area. Metal exhibit exceptional stability, specificity, sensitivity, effectiveness, making them highly useful biomedical field. are high demand nanotechnology, including Au, Ag, Pt, Cu, Zn, Co, Gd, Eu, Er. These particles excellent physicochemical amenable functionalization, non-corrosiveness, varying optical electronic properties based on shape. can be modified different targeting agents antibodies, liposomes, transferrin, folic acid, carbohydrates. Thus, hold great promise for various applications photoacoustic imaging, magnetic resonance computed tomography (CT), photothermal, photodynamic therapy (PDT). Despite potential, safety considerations, regulatory hurdles must addressed safe clinical applications. This review highlights nanoparticle engineering explores integration emerging technologies bioimaging, cancer therapeutics nanomedicine. By offering valuable insights, this comprehensive offers a deep understanding potential research.

Language: Английский

Citations

44
Towards realizing nano-enabled precision delivery in plants DOI
Gregory V. Lowry, Juan Pablo Giraldo, Nicole F. Steinmetz

et al.

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(9), P. 1255 - 1269

Published: June 6, 2024

Language: Английский

Citations

31
Metal–organic frameworks in drug delivery: engineering versatile platforms for therapeutic applications DOI Creative Commons
Doaa S. R. Khafaga,

Manar T. El-Morsy,

Habiba Faried

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(41), P. 30201 - 30229

Published: Jan. 1, 2024

Recently, metal-organic frameworks (MOFs) have attracted much attention as versatile materials for drug delivery and personalized medicine. MOFs are porous structures made up of metal ions coupled with organic ligands. This review highlights the synthesis techniques used to design specific features such surface area pore size, encapsulation within not only improves their stability solubility but also allows controlled release kinetics, which therapeutic efficacy minimizes adverse effects. Furthermore, it discusses challenges potential advantages MOF-based delivery, MOF stability, biocompatibility, scale-up production. With further advancements in synthesis, functionalization techniques, understanding interactions using biological systems, can significant promise expanding medicine improving patient outcomes.

Language: Английский

Citations

20
Nanotherapy for Neural Retinal Regeneration DOI Creative Commons

Chuyao Yu,

Dong Li,

Yujia Lv

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Retinal diseases can severely impair vision and even lead to blindness, posing significant threats both physical mental health. Physical retinal regenerative therapies are poised revolutionize the treatment of various disorders associated with blindness. However, these must overcome challenges posed by protective inner outer blood‒retinal barriers. Nanotechnology applications in ophthalmology have shown great potential addressing issue drug delivery eye. Moreover, nanotechnology-based therapeutics profound clinical impacts on retinopathy, particularly regeneration, thereby improving patient outcomes. Continuous advancements nanotechnology being applied regenerate lost or damaged eye tissues treat loss blindness caused degenerative diseases. These approaches be categorized into three main strategies: i) nanoparticles for delivering drugs, genes, other essential substances; ii) nanoscaffolds providing biocompatible support; iii) nanocomposites enhancing functionality primary stem cells. The aim this comprehensive review is present current understanding a focus perspective functions nanomaterials.

Language: Английский

Citations

2